Zvi Israel
Hadassah Medical Center
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Publication
Featured researches published by Zvi Israel.
Neuromodulation | 2015
Jeff M. Bronstein; Michele Tagliati; Cameron C. McIntyre; Robert Chen; Tyler Cheung; Eric L. Hargreaves; Zvi Israel; Michael A. Moffitt; Erwin B. Montgomery; Paul H. Stypulkowski; Jay L. Shils; Timothy Denison; Jerrold L. Vitek; Jens Volkman; Jeffrey Wertheimer; Michael S. Okun
Deep brain stimulation (DBS) is an effective therapy for the treatment of a number of movement and neuropsychiatric disorders. The effectiveness of DBS is dependent on the density and location of stimulation in a given brain area. Adjustments are made to optimize clinical benefits and minimize side effects. Until recently, clinicians would adjust DBS settings using a voltage mode, where the delivered voltage remained constant. More recently, a constant‐current mode has become available where the programmer sets the current and the stimulator automatically adjusts the voltage as impedance changes.
Journal of Neurosurgery | 2018
John A. Thompson; Salam Oukal; Hagai Bergman; Steven Ojemann; Adam O. Hebb; Sara J. Hanrahan; Zvi Israel; Aviva Abosch
OBJECTIVEDeep brain stimulation (DBS) of the subthalamic nucleus (STN) has become standard care for the surgical treatment of Parkinsons disease (PD). Reliable interpretation of microelectrode recording (MER) data, used to guide DBS implantation surgery, requires expert electrophysiological evaluation. Recent efforts have endeavored to use electrophysiological signals for automatic detection of relevant brain structures and optimal implant target location.The authors conducted an observational case-control study to evaluate a software package implemented on an electrophysiological recording system to provide online objective estimates for entry into and exit from the STN. In addition, they evaluated the accuracy of the software in selecting electrode track and depth for DBS implantation into STN, which relied on detecting changes in spectrum activity.METHODSData were retrospectively collected from 105 MER-guided STN-DBS surgeries (4 experienced neurosurgeons; 3 sites), in which estimates for entry into and exit from the STN, DBS track selection, and implant depth were compared post hoc between those determined by the software and those determined by the implanting neurosurgeon/neurophysiologist during surgery.RESULTSThis multicenter study revealed submillimetric agreement between surgeon/neurophysiologist and software for entry into and exit out of the STN as well as optimal DBS implant depth.CONCLUSIONSThe results of this study demonstrate that the software can reliably and accurately estimate entry into and exit from the STN and select the track corresponding to ultimate DBS implantation.
bioRxiv | 2018
Odeya Marmor; Pnina Rapple; D. V. Valsky; Atira S. Bick; David Arkadir; Eduard Linetzky; Or Peled; Idit Tamir; Hagai Bergman; Zvi Israel; Renana Eitan
To understand the mechanism of movement facilitation and inhibition in the subthalamic nucleus (STN), we recorded intra-operatively subthalamic multiunit activity while parkinsonian patients (n=43 patients, 173 recording sites) performed increasingly complex oddball paradigms: auditory task, simple movement task and movement inhibition task. We found that the human STN responds mainly to movement-involving tasks: movement execution at the motor STN and movement planning at the limbic-associative STN. At the limbic-associative STN, responses to the inhibitory cue (deviant tone) in the movement inhibition task were not significantly different from the simple movement task. However, responses to the go cue (frequent tone) were significantly decreased in the movement inhibition task. Successful motor inhibition was correlated with a higher baseline activity before the inhibitory cue. We therefore suggest that the subthalamic nucleus adapts to movement inhibition context by selectively decreasing the amplitude of neuronal activity. Smaller fluctuations might enable better preparation for possible inhibition.Abstract To better understand the mechanism of movement facilitation and inhibition in the subthalamic nucleus (STN), we recorded subthalamic multiunit activity intra-operatively while parkinsonian patients (n=43 patients, 173 sites) performed increasingly complex oddball paradigms: auditory (‘None-Go’, n=7, 28), simple movement (‘All-Go’, n=7, 26) and movement inhibition (‘Go-NoGo’, n=29, 119) tasks. To enable physiological sampling of the different subthalamic nucleus domains in both hemispheres, each patient performed one of the oddball paradigms several times. The human STN responded mainly to movement-involving tasks: movement execution at the motor STN and movement planning at the limbic-associative STN. In the limbic-associative STN, responses to the inhibitory cue (deviant tone) in the movement inhibition task were not significantly different from the simple movement task. However, responses to the go cue (frequent tone) were significantly reduced. The reduction was mainly in the negative component of the evoked response amplitude. Successful movement inhibition was correlated with higher baseline activity before the inhibitory cue. We suggest that the STN adapts to movement inhibition context by selectively decreasing the amplitude of neuronal activity. Thus, the STN enables movement inhibition not by increasing responses to the inhibitory cue but by reducing responses to the release cue. The negative component of the evoked response probably facilitates movement and a higher baseline activity enables successful inhibition of movement. These discharge modulations were found in the ventromedial, non-motor domain of the STN and therefore suggest a significant role of the associative-limbic domains in movement planning and in global movement regulation.
Archive | 2011
Hermona Soreq; Hagai Bergman; David Greenberg; Zvi Israel; Lilach Soreq
Neurosurgery | 1998
Nachshon Knoller; Lion Levi; Zvi Israel; Nisim Razon; Eli Reichenthal; Zvi H. Rappaport; Noa Ehrenfreund; Anat Biegon
Neurosurgery | 2018
Reuben R. Shamir; Yuval Duchin; Jinyoung Kim; Rémi Patriat; Odeya Marmor; Hagai Bergman; Jerrold L. Vitek; Guillermo Sapiro; Atira Bick; Ruth Eliahou; Renana Eitan; Zvi Israel; Noam Harel
Archive | 2017
Omer Naor; Adi Balan; Hagai Bergman; Imad Younis; Oren A. Gargir; Zvi Israel; Jubran Elfar; Paul Mcsherry; Steven Scott; Benjamin Matter
Archive | 2016
Majid Mechael; D. V. Valsky; Hagai Bergman; Zvi Israel
Deep Brain Stimulation: Technology and Applications (Volume 1) | 2014
Jerrold L. Vitek; Hagai Bergman; Zvi Israel; Boris Rosin
Archive | 2011
Zvi Israel; John Winestone; Adam Zaidel; Boris Rosin; Lilach Soreq; Renana Eitan; Hagai Bergman