A. A. Gorbunov

Novel thiophene-containing push-pull chromophores that include carbazole and triphenylamine moieties: study of optical and electrochemical properties

Novel carbazole- and triphenylamine-containing alkylidene malononitriles that include thiophene and bithienyl fragments as π-spacers were synthesized. Quantum-chemical calculations of the frontier molecular orbital energies were performed using the B3LYP/6-31G(d) method with regard to solvent. Electronic absorption spectra and fluorescence spectra were recorded for all the obtained compounds; their electrochemical properties were also studied. The experimental energy values of HOMO and LUMO levels were derived from resulting data. Thin films were obtained by the spin coating technique, and their surface morphology was studied using a NTEGRA Prima scanning tunneling microscope.

Eugenol and its methyl ether in the synthesis of 3-methyl derivatives of 3,4-dihydroisoquinoline

Abstract3-Methyl derivatives of 1-substituted 3,4-dihydroisoquinoline were obtained proceeding from eugenol and its methyl ether. The propylene oxide in a three-component reaction with veratrol and ethyl cycnoacetate provided the reaction products in a low yield. The isoeugenol in a linear synthesis also gives a low yield of the target compounds.

Mandelonitrile in Synthesis of Partially Hydrogenated Isoquinoline Derivatives

New procedures for preparing tetrahydroisoquinoline derivatives using available chemicals are described.

Synthesis and biological activity of substituted (3,3-dimethyl-1,2,3,4-tetrahydroisoquinolylidene-1) acetanilides and malonanilides

Substituted amides of the isoquinoline series include compounds with high levels of antiarrhythmic and antiaggregant activities [4]. We report here the synthesis of new compounds of this class, i.e. substituted (3,3-dimethyl-l,2,3,4tetrahydroisoquinolylidene-1)acetanilides (I) and malonanilides (II), with the aim of identifying the relationship between their structures and antiarrhythmic and antiaggregant properties.

Synthesis of 1-functionalized di- and tetramethyl-3,4-dihydrobenzofuro[3,2-g]-and [2,3-h]isoquinoline derivatives

Linear and angular 1-substituted derivatives of 3,3-di- and 3,3,4,4-tetramethyl-3,4-dihydrobenzofuroisoquinoline were obtained under Ritter reaction conditions, and the stereochemical features of these compounds were analyzed.

Drug synthesis methods and manufacturing technology preparative chromatographic separation of ibuprofen enantiomers on Whelk-O1 chiral stationary phase

The influence of experimental conditions (temperature, sample volume, mobile-phase composition) on the preparative separation of ibuprofen enantiomers on chiral stationary phase (S,S)-Whelk-O1 with hexane: EtOH eluents modified with acetic acid was studied. It was established that the effects of these factors on the elution profiles were complex with the patterns disturbed by overlap with the systemic peak. The importance of the last factor decreased with increasing alcohol concentration in the mobile phase. The possibility of optimizing the preparative separation with respect to both purity and yield of the target enantiomers was discussed.

Synthesis and study of antiarrhythmic and antiaggregative activity of amidino acids of the 3,4-dihydroisoquinoline series

It was reported that compounds containing amidino groups exhibit antiarrhythmic activity [1 -3] . According to other data [4 6], many of the 3,4-dihydroisoquinoline derivatives are also capable of producing the antiarrhythmic effect. Therefore, it was of interest to synthesize the derivatives of 3,4-dihydroisoquinoline with amidino groups and study their antiarrhythmic and antiaggregative activity. The target compounds were obtained by the reaction between l-methylthio-3,3-dimethyl-3,4-dihydroquinoline (I) and amino acids (IIa IIh) containing primary amino groups.

Interaction of 1-methylthio-3,3-dimethyl-3,4-dihydroisoquinoline with ?-dicarboxylic acids, ?-dicarbonyl compounds, and their analogs

Abstract1-Methylthio-3,3-dimethyl-3,4-dihydroisoquinoline interacts as an electrophile with Β-dicarbonyl compounds and their analogs to form products in which one or two hydrogen atoms of the Β-carbonyl compound are replaced by a 3,3-dimethy 1-3,4-dihydroisoquinolyl or 3,3-dimethyl-1,2,3,4-tetrahydroisoquinolylidene fragment.

Synthesis of new pyrrolo[3,2-l]acridinones and pyrrolo[3,2-c][1,8]naphthyridinones by condensation of methoxybenzenes or phenols with isobutyric aldehyde and o-aminonitriles

A reaction of methoxybenzenes or phenols with isobutyric aldehyde and 2-amino-5-nitro- or 2-amino-4-chlorobenzonitriles in concentrated H2SO4 medium was used for the preparation of new pyrrolo[3,2-l]acridinone derivatives. Analogous reactions using 2-amino-3-pyridinecarbonitrile enabled the synthesis of previously unknown benzo[b]pyrrolo[3,2-c][1,8]naphthyridinones.

New Tetrathiafulvalenes Containing Carbazole and 1,3,5-Triazine Fragments: Synthesis, Electro-Chemical and Optical Properties

New tetrathiafulvalenes, containing carbazole and 1,3,5-triazine fragments added to the tetrathia-fulvalene ring by means of a S–CH2–CH2–O bridge, were synthesized. The electrochemical properties of the initial compounds and of the final products were investigated by cyclic voltammetry. The optical characteristics of their solutions were studied by UV absorption spectroscopy and fluorescence spectroscopy.