A. Andeweg

Pandemic 2009 H1N1 Influenza Virus Causes Diffuse Alveolar Damage in Cynomolgus Macaques

The pathogenesis of lower respiratory tract disease from the pandemic 2009 H1N1 (H1N1v) influenza A virus is poorly understood. Therefore, either H1N1v virus or a seasonal human H1N1 influenza A virus was inoculated into cynomolgus macaques as a nonhuman primate model of influenza pneumonia, and virological, pathological, and microarray analyses were performed. Macaques in the H1N1v group had virus-associated diffuse alveolar damage involving both type I and type II alveolar epithelial cells and affecting an average of 16% of the lung area. In comparison, macaques in the seasonal H1N1 group had milder pulmonary lesions. H1N1v virus tended to be reisolated from more locations in the respiratory tract and at higher titers than seasonal H1N1 virus. In contrast, differential expression of messenger RNA transcripts between H1N1v and seasonal H1N1 groups did not show significant differences. The most upregulated genes in H1N1v lung samples with lesions belonged to the innate immune response and proinflammatory pathways and correlated with histopathological results. Our results demonstrate that the H1N1v virus infects alveolar epithelial cells and causes diffuse alveolar damage in a nonhuman primate model. Its higher pathogenicity compared with a seasonal H1N1 virus may be explained in part by higher replication in the lower respiratory tract.

Griezelig gewoon : Gotieke verschijningen in Nederlandse romans, 1980-1995

Hedendaagse Nederlandse auteurs putten naar hartenlust uit het repertoire van de gothic novel. In dit boek analyseert Agnes Andeweg zes van zulke gotieke romans van auteurs als Frans Kellendonk, Gerard Reve, Thomas Rosenboom en Renate Dorrestein. Deze romans laten zich lezen als een commentaar op de moderniseringen van de Nederlandse samenleving in de jaren zestig en zeventig. Op grond van deze analyses kan het bestaande beeld van de Nederlandse roman in de jaren tachtig bijgesteld worden. Literatuur uit die periode is wel beschuldigd van een gebrek aan engagement. Gelezen door de lens van het gotieke blijken de hier gepresenteerde romans niet onmaatschappelijk te zijn, maar juist zeer betrokken bij de fricties over nieuwe definities van sekse, seksualiteit, sociale mobiliteit, vriendschap en religie.

Leef je in! Van M-woord naar L-woord en terug.

In this essay I address the popular notion that reading literature is a way to gain empathy through identification. Using the relatively new phenomenon of the lesbian mother as an example, I ask through which cultural repertoires lesbian mothers are made visible, which subject positions are available for them, and which identificatory positions are made available to readers. I explore a number of representations of lesbian mothers from comics, TV-series, films and Dutch children’s books. Depending on whether the lesbian mother is initially presented as a lesbian or as a mother, and depending on the context, a different coming out process is at stake: either she has to come out as a(n aspiring) mother; or she has to come out as a lesbian.