Ace Tatang Hidayat

A new limonoid from stem bark of Chisocheton pentandrus (Meliaceae)

Abstract A new limonoid, pentandricine (1), along with three known limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3), 6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been isolated from the stembark of Chisocheton pentandrus. The chemical structures of the new compound were elucidated on the basis of spectroscopic evidence. All of the compounds were tested for their cytotoxic effects against MCF-7 breast cancer cells. Compounds 1–4 showed weak and no cytotoxicity against MCF-7 breast cancer cells with IC50 values of 369.84, 150.86, 208.93 and 120.09 μM, respectively.

Activity of Cytotoxic Flavanoids against a P-388 Murine Leukemia Cell Line from the Stem Bark of Aglaia elliptica (Meliaceae)

800x600 Two mixture s of flavanoid compounds ( 1 and 2 ), a mixture of catechin ( 1a ) and epicatechin ( 1b ) , and a mixture of gallocatechin ( 2a ) and epigallocatechin ( 2b ) , were isolated from the active fraction of the stem bark of Aglaia elliptica methanol extract. The chemical structure of the compounds w as identified with spectroscopic data , including UV, IR, NMR ( 1 H, 13 C, DEPT 135°, HMQC, HMBC, 1 H- 1 H COSY) , and MS, and additionally compared with previously reported spectral data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compound 2 showed cytotoxicity against the P-388 murine leukemia cell , with an IC 50 value of 7.79 µg/mL, but compound 1 wa s found not to be active ( more than 100 µg/mL ) . Normal 0 false false false EN-ID X-NONE X-NONE

Cytotoxic Steroids from the Bark of Aglaia argentea (Meliaceae)

The study aimed to find a potential anticancer agent by isolating and identifying the chemical structure of compounds from Aglaia argentea and testing their cytotoxic effects against P-388 murine leukimia cells. Five steroids – stigmast-5-en-3β-ol (β-sitosterol) (1), stigmast-5-en-3β-ol-3β-oleate (β-sitosterol oleate) (2), stigmast-5-en-3β-ol-3-O-(6′-O-oleoyl)-β-D-glucopyranoside (sitoindoside II) (3), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (β-sitosterol glucoside) (4), stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (stigmasterol glucoside) (5) – were isolated from the bark of Aglaia argentea. The chemical structures of 1-5 were identified with spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY) and HRTOFMS, as well as by comparing with previously reported spectral data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-5 showed cytotoxicity against P-388 murine leukemia cell with IC50 values of 12.45 ± 0.050, 85.25 ± 0.050, >100, 52.27 ± 0.031 and 62.52 ± 0.076 μg/mL, respectively.