Rani Maharani

A new limonoid from stem bark of Chisocheton pentandrus (Meliaceae)

Abstract A new limonoid, pentandricine (1), along with three known limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3), 6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been isolated from the stembark of Chisocheton pentandrus. The chemical structures of the new compound were elucidated on the basis of spectroscopic evidence. All of the compounds were tested for their cytotoxic effects against MCF-7 breast cancer cells. Compounds 1–4 showed weak and no cytotoxicity against MCF-7 breast cancer cells with IC50 values of 369.84, 150.86, 208.93 and 120.09 μM, respectively.

ANTIBACTERIAL TRITERPENOIDS FROM THE BARKS AND LEAVES OF Lansium domesticum Corr cv. Kokossan (MELIACEAE)

Three triterpenoid compounds, 8,14-secogammacera-7,14-dien-3,21-dione (1), 8,14-secogammacera-7en-14-hydroxy-3,21-dione (2) and 9,19-cyclolanost-24-en-3-one, 21,23 epoxy-21,22-dihydroxy (21R, 22S, 23S) (3) has been isolated from the barks and leaves of L. domesticum cv kokossan (Meliaceae). The chemical structures of compounds 1-3 were identified with spectroscopic data, including UV, IR, NMR and MS, and their spectra were compared with previously reported spectra data. Compound 1, 2 were evaluated for their antibacterial effects against Escherichia coli and Bacillus ereus. Compound 3 was evaluated for their antibacterial effects against Escherichia coli and Enterococcus feacalis. Compound 1 showed the inhibition zone values of 7.5 dan 8.0 mm at 500 and 1000 ppm against Escherichia coli, whereas for Bacillus cereus it was inactive. Compound 2 showed the inhibition zone values of 8.0 dan 10.0 mm at concentrations of 500 and 1000 ppm against Escherichia coli, whereas for Bacillus cereus it was inactive. Compound 3 showed the inhibition zone values of 3.67 mm, 3.17 mm, 2.32 mm at concentrations of 10000, 5000 and 1000 ppm respectively against Escherichia coli, whereas for Enterococcus feacalis it was inactive.

Activity of Cytotoxic Flavanoids against a P-388 Murine Leukemia Cell Line from the Stem Bark of Aglaia elliptica (Meliaceae)

800x600 Two mixture s of flavanoid compounds ( 1 and 2 ), a mixture of catechin ( 1a ) and epicatechin ( 1b ) , and a mixture of gallocatechin ( 2a ) and epigallocatechin ( 2b ) , were isolated from the active fraction of the stem bark of Aglaia elliptica methanol extract. The chemical structure of the compounds w as identified with spectroscopic data , including UV, IR, NMR ( 1 H, 13 C, DEPT 135°, HMQC, HMBC, 1 H- 1 H COSY) , and MS, and additionally compared with previously reported spectral data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compound 2 showed cytotoxicity against the P-388 murine leukemia cell , with an IC 50 value of 7.79 µg/mL, but compound 1 wa s found not to be active ( more than 100 µg/mL ) . Normal 0 false false false EN-ID X-NONE X-NONE

Cytotoxic Steroids from the Bark of Aglaia argentea (Meliaceae)

The study aimed to find a potential anticancer agent by isolating and identifying the chemical structure of compounds from Aglaia argentea and testing their cytotoxic effects against P-388 murine leukimia cells. Five steroids – stigmast-5-en-3β-ol (β-sitosterol) (1), stigmast-5-en-3β-ol-3β-oleate (β-sitosterol oleate) (2), stigmast-5-en-3β-ol-3-O-(6′-O-oleoyl)-β-D-glucopyranoside (sitoindoside II) (3), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (β-sitosterol glucoside) (4), stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (stigmasterol glucoside) (5) – were isolated from the bark of Aglaia argentea. The chemical structures of 1-5 were identified with spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY) and HRTOFMS, as well as by comparing with previously reported spectral data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-5 showed cytotoxicity against P-388 murine leukemia cell with IC50 values of 12.45 ± 0.050, 85.25 ± 0.050, >100, 52.27 ± 0.031 and 62.52 ± 0.076 μg/mL, respectively.