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Dive into the research topics where Akihiko Narita is active.

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Featured researches published by Akihiko Narita.


Chemistry: A European Journal | 2002

Cover Picture: Chem. Eur. J. 20/2002

Toshikazu Bando; Akihiko Narita; Isao Saito; Hiroshi Sugiyama

The cover picture shows the energy-minimized structure of the dCAAGTCAGAG/dCTCTGACTTG pyrrole–imidazole (blue and red, respectively, hairpin CPI conjugate complex (CPI = cyclopropylpyrroloindole). Minimization was performed in the presence of 18 sodium cations and a 10 A layer of H2O by CFF force-field parameters. Each strand of DNA is drawn in white and ribbon representation is drawn in light blue. The CPI conjugate effectively alkylated the A moiety (purple) of 5′-AGTCA-3′ site at nanomolar concentration. Further work is described in more detail by H. Sugiyama et al. on p. 4781 ff.


Chemistry: A European Journal | 2002

Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation.

Toshikazu Bando; Akihiko Narita; Isao Saito; Hiroshi Sugiyama


Journal of the American Chemical Society | 2004

Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides.

Ken-ichi Shinohara; Akihiko Narita; Takanori Oyoshi; Toshikazu Bando; Hirobumi Teraoka; Hiroshi Sugiyama


Journal of the American Chemical Society | 2003

Inhibition of Transcription at a Coding Sequence by Alkylating Polyamide

Takanori Oyoshi; Wakana Kawakami; Akihiko Narita; Toshikazu Bando; Hiroshi Sugiyama


Chemistry & Biology | 2003

Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides.

Toshikazu Bando; Hirokazu Iida; Zhi-Fu Tao; Akihiko Narita; Noboru Fukuda; Takao Yamori; Hiroshi Sugiyama


Journal of the American Chemical Society | 2003

Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates

Toshikazu Bando; Akihiko Narita; Isao Saito; Hiroshi Sugiyama


Journal of the American Chemical Society | 2004

Enantioselective DNA alkylation by a pyrrole-imidazole S-CBI conjugate

Toshikazu Bando; Akihiko Narita; Ken Asada; Hirohito Ayame; Hiroshi Sugiyama


Journal of the American Chemical Society | 2005

Specific adenine alkylation by pyrrole-imidazole CBI conjugates.

Toshikazu Bando; Akihiko Narita; Shunta Sasaki; Hiroshi Sugiyama


Journal of the American Chemical Society | 2004

C-H to N substitution dramatically alters the sequence-specific DNA alkylation, cytotoxicity, and expression of human cancer cell lines

Toshikazu Bando; Akihiko Narita; Aki Iwai; Kazunori Kihara; Hiroshi Sugiyama


Nucleic acids symposium series (2004) | 2004

Molecular design of alkylating pyrrole-imidazole polyamides with indole linker

Shunta Sasaki; Akihiko Narita; Toshikazu Bando; Hiroshi Sugiyama

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Toshikazu Bando

Tokyo Medical and Dental University

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Takanori Oyoshi

Tokyo Medical and Dental University

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Wakana Kawakami

Tokyo Medical and Dental University

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Aki Iwai

Tokyo Medical and Dental University

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Hirobumi Teraoka

Tokyo Medical and Dental University

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Hirohito Ayame

Tokyo Medical and Dental University

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Hirokazu Iida

Tokyo Medical and Dental University

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