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Dive into the research topics where Hiroshi Sugiyama is active.

Publication


Featured researches published by Hiroshi Sugiyama.


Nucleic acids research. Supplement (2001) | 2001

Molecular design of hairpin imidazole-pyrrole polyamide for effective DNA alkylation

Toshikazu Bando; Akihiko Narita; Isao Saito; Hiroshi Sugiyama

A new type of hairpin polyamide-CPI conjugate possessing a vinyl linker has been synthesized. Sequence-selective alkylation of double-stranded DNA by conjugates was investigated by high resolution denaturing gel electrophoresis using 450 bp DNA fragments. Highly-efficient DNA alkylation predominantly occurs at the purines of 5-(A/T)G(T/A)CPu-3 site at nanomolar concentration.


Archive | 2002

Method of the solid phase synthesis of pyrrole-imidazole polyamide

Hiroshi Sugiyama; Hirokazu Iida; Isao Saito; Takashi Saito


Archive | 2001

Interstrand crosslinking agents for dna and compounds therefor

Hiroshi Sugiyama; Toshikazu Bando; Hirokazu Iida; Isao Saito


Archive | 2005

METHOD FOR SCREENING PHYSIOLOGICALLY ACTIVE PYRROLE IMIDAZOLE DERIVATIVE

Hiroichi Iida; Retsu Saito; Hiroshi Sugiyama; 弘 杉山; 博一 飯田; 烈 齋藤


Archive | 2003

Novel hairpin polyamide

Hiroshi Sugiyama; Toshikazu Bando; Isao Saito


Archive | 2009

Histone modification inhibitor specific to target gene

Hiroki Nagase; Hiroshi Sugiyama; Tukasa Suzuki; Toshikazu Bando; Makoto Kimura; Akimichi Ohtsuki


Archive | 2005

Tgf-Beta Gene Expression Inhibitor

Noboru Fukuda; Takahiro Ueno; Hiroshi Sugiyama


Archive | 2006

AUTOMATED SOLID PHASE SYNTHESIS OF PYRROLE-IMIDAZOLE POLYAMIDE

Hiroshi Sugiyama; Chikara Dohno; Noboru Fukuda


Archive | 2000

Compounds capable of cleaving double-stranded dna and method of utilization of the same

Hiroshi Sugiyama; Zhi-Fu Tao; Isao Saito


Nucleic acids research. Supplement (2001) | 2003

Fmoc solid-phase synthesis and its application to pyrroleimidazole polyamides

Hirohito Ayame; Takashi Saito; Toshikazu Bando; Noboru Fukuda; Hiroshi Sugiyama

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Toshikazu Bando

Tokyo Medical and Dental University

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Hirokazu Iida

Tokyo Medical and Dental University

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Akihiko Narita

Tokyo Medical and Dental University

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