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Dive into the research topics where Alexander W. Aleem is active.

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Featured researches published by Alexander W. Aleem.


Clinics in Sports Medicine | 2012

Outcomes of Rotator Cuff Surgery What Does the Evidence Tell Us

Alexander W. Aleem; Robert H. Brophy

Rotator cuff disease accounts for more than 4.5 million annual visits to a physician, and more than 75,000 surgical repairs are performed a year. Surgical techniques have evolved from all open repairs to all arthroscopic repairs being the most commonly used. The purpose of this article is to review the current evidence regarding the outcomes of surgical techniques in rotator cuff surgery. Reported outcomes have been favorable with open, mini-open, and arthroscopic repairs. Recently, a committee sponsored by the AAOS published a clinical practice guideline summary regarding the management of rotator cuff tears. The guidelines touched aspects of both nonoperative and operative repair. In regard to operative repair, the committee could not recommend a modality of surgical repair (eg, arthroscopic vs open) as a superior method, citing a lack of comparative studies. The theoretical advantage of arthroscopic surgery lies in smaller soft tissue dissection and the ability to evaluate and treat the glenohumeral joint. However, no study using patient-based outcomes has shown superiority compared with open or mini-open repairs. With the method of surgical repair not changing outcomes, investigation has recently focused on optimizing bone-tendon healing in rotator cuff repair. Double-row fixation allows for a more anatomic reapproximation of the rotator cuff footprint on the greater tuberosity versus single-row and has been shown to be biomechanically superior. Despite this, no clinical studies have shown superiority of one type of repair versus the other. The AAOS committee citing similar evidence gave a weak recommendation for the use of achieving tendon-to-bone healing with double-row fixation. Transosseous-equivalent repair, which provides a high compressive force on the tendon-to-bone interface of repair, is the newest fixation method under investigation to optimize healing. The use of collagen and biologic augmentation has gained interest as researchers are attempting to optimize rotator cuff healing. There is moderate evidence against the use of porcine small intestine submucosa xenograft patches. Other commercially available collagen augments have yet to be proven as either beneficial or detrimental. Other than PRP, which has not shown to have any benefit augmenting repair, no biologic augment has been investigated clinically. Overall, rotator cuff surgery portends a good outcome for appropriately selected patients. However, there is not much high-quality evidence-based research that can be used to conclude what surgical treatments are superior or appropriate for a given patient. Future research should be aimed at identifying whether and in whom rotator cuff healing is appropriate to better identify surgical candidates as well as to determine the best surgical repair strategy.


Journal of Shoulder and Elbow Surgery | 2015

Predictors of surgical revision after in situ decompression of the ulnar nerve

Justin D. Krogue; Alexander W. Aleem; Daniel A. Osei; Charles A. Goldfarb; Ryan P. Calfee

BACKGROUND This study was performed to identify factors associated with the need for revision surgery after in situ decompression of the ulnar nerve for cubital tunnel syndrome. METHODS This case-control investigation examined all patients treated at one institution with open in situ decompression for cubital tunnel syndrome between 2006 and 2011. The case patients were 44 failed decompressions that required revision, and the controls were 79 randomly selected patients treated with a single operation. Demographic data and disease-specific data were extracted from the medical records. The rate of revision surgery after in situ decompression was determined from our 5-year experience. A multivariate logistic regression model was used based on univariate testing to determine predictors of revision cubital tunnel surgery. RESULTS Revision surgery was required in 19% (44 of 231) of all in situ decompressions performed during the study period. Predictors of revision surgery included a history of elbow fracture or dislocation (odds ratio [OR], 7.1) and McGowan stage I disease (OR, 3.2). Concurrent surgery with in situ decompression was protective against revision surgery (OR, 0.19). DISCUSSION The rate of revision cubital tunnel surgery after in situ nerve decompression should be weighed against the benefits of a less invasive procedure compared with transposition. When considering in situ ulnar nerve decompression, prior elbow fracture as well as patients requesting surgery for mild clinically graded disease should be viewed as risk factors for revision surgery. Patient factors often considered relevant to surgical outcomes, including age, sex, body mass index, tobacco use, and diabetes status, were not associated with a greater likelihood of revision cubital tunnel surgery.


Spine deformity | 2015

Spinal Cord Monitoring Data in Pediatric Spinal Deformity Patients With Spinal Cord Pathology

Alexander W. Aleem; Earl D. Thuet; Anne M. Padberg; Michael Wallendorf; Scott J. Luhmann

STUDY DESIGN Retrospective. OBJECTIVES The purpose of this study is to review the efficacy of monitoring data and outcomes in pediatric patients with spinal cord pathology. SUMMARY OF BACKGROUND DATA The incidence of spinal cord pathology in pediatric patients with scoliosis has been reported between 3% and 20%. Previous studies demonstrated that intraoperative spinal cord monitoring (IOM) during scoliosis surgery can be reliable despite underlying pathology. METHODS A single-center retrospective review of 119 spinal surgery procedures in 82 patients with spinal cord pathology was performed. Diagnoses included Arnold-Chiari malformation, syringomyelia, myelomeningocele, spinal cord tumor, tethered cord, and diastematomyelia. Baseline neurologic function and history of prior neurosurgical intervention were identified. Outcome measures included ability to obtain reliable monitoring data during surgery and presence of postoperative neurologic deficits. Results were compared for 82 patients with adolescent idiopathic scoliosis (AIS). RESULTS Usable IOM data were obtained in 82% of cases (97/119). Twenty-two cases (18%) had no lower extremity data. Patients with Arnold-Chiari malformation or syringomyelia pathologies, in isolation or together, had a significantly higher rate of reliable data compared to other pathologies (p < .0001). Among study group cases with usable data, there were 1 false negative (1%) and 4 true positive (4%) outcomes. There were no permanent neurologic deficits. The spinal cord pathology group demonstrated 80% sensitivity and 92% specificity. CONCLUSIONS Spinal cord monitoring is a valuable tool in pediatric patients with spinal cord pathology undergoing spinal deformity surgeries. When obtained, data allow to detect changes in spinal cord function. Patients with a diagnosis of Arnold-Chiari or syringomyelia have monitoring data similar to those patients with AIS. Patients with other spinal cord pathologies have less reliable data, and surgeons should have a lower threshold for performing wake-up tests to assess spinal cord function intraoperatively.


Journal of Shoulder and Elbow Surgery | 2016

Functional outcomes after bilateral arthroscopic rotator cuff repair.

Alexander W. Aleem; Usman Ali M. Syed; Jocelyn Wascher; Adam C. Zoga; Koby Close; Joseph A. Abboud; Steven B. Cohen

BACKGROUND Arthroscopic repair of rotator cuff tears is a common procedure performed by orthopedic surgeons. There is a well-known incidence of up to 35% of bilateral rotator cuff tear disease in patients who have a known unilateral tear. The majority of the literature focuses on outcomes after unilateral surgery. The purpose of this study was to determine if there are clinical differences in shoulders of patients who underwent staged bilateral rotator cuff repairs during their lifetime. METHODS A retrospective review of all patients who underwent staged bilateral arthroscopic rotator cuff surgery at our institution was performed. All patients had at least 2 years of follow-up. Clinical outcome scores including the American Shoulder and Elbow Surgeons (ASES), Single Assessment Numeric Evaluation, and Rowe measures were obtained. A subset of patients returned for clinical and ultrasound evaluation performed by an independent fellowship-trained musculoskeletal radiologist. RESULTS Overall, 110 shoulders in 55 patients, representing 68% of all eligible patients, participated. No clinical or statistical difference was found in any outcome measure. ASES scores averaged 86.5 (36.7-100) in the dominant shoulder compared with 89.6 (23.3-100) in the nondominant shoulder (P = .42). Ultrasound was available on 34 shoulders and showed complete healing rate of 88%. The shoulders with retearing of the rotator cuff (12%) demonstrated clinically relevant lower ASES scores (72.5) compared with shoulders with confirmed healed repairs (86.2; P = .2). DISCUSSION Patients who undergo staged bilateral rotator cuff repair can expect to have similarly good clinical outcomes regardless of hand dominance or chronologic incidence with excellent healing rates in both shoulders.


Orthopedics | 2017

Effect of Humeral Component Version on Outcomes in Reverse Shoulder Arthroplasty

Alexander W. Aleem; Brian T. Feeley; Luke Austin; C. Benjamin Ma; Ryan Krupp; Matthew L. Ramsey; Charles L. Getz

Although reverse shoulder arthroplasty provides excellent clinical results in appropriately selected patients, loss of external and internal rotation may occur. Component selection, design, and placement affect postoperative results. Recent studies considered the effect of humeral component version on functional results. The current study investigated whether humeral stem retroversion affects the outcomes of reverse shoulder arthroplasty with a retrospective review of a multisurgeon, industry-sponsored, prospectively gathered database of a single reverse shoulder arthroplasty implant. All patients had at least 2-year follow-up. Clinical outcomes, including American Shoulder and Elbow Surgeons score, visual analog scale pain score, Short Form-12 Mental and Physical Component scores, range of motion, and internal rotation function, were compared between patients with humeral retroversion of 10° or less (group A) and those with humeral retroversion of 20° or greater (group B). Radiographic outcomes were compared. The analysis included 64 patients (group A, 29 patients; group B, 35 patients). No clinical or statistically significant difference was found in American Shoulder and Elbow Surgeons scores. Both groups showed statistical and clinical improvement vs preoperative scores, with group A averaging 77.8 and group B averaging 79.2 at final follow-up. No differences were found between groups in range of motion or ability to perform tasks that require shoulder internal rotation. Patients can expect good clinical improvement after reverse shoulder arthroplasty. No difference was found in clinical or radiologic outcomes based on humeral component retroversion. Despite the theoretical increase in external rotation when the humeral component is placed closer to native retroversion, the results did not show this effect. [Orthopedics. 2017; 40(3):179-186.].


Journal of Shoulder and Elbow Surgery | 2018

Total shoulder arthroplasty in patients with a B2 glenoid addressed with corrective reaming

Nathan D. Orvets; Aaron M. Chamberlain; Brendan M. Patterson; Peter N. Chalmers; Michelle Gosselin; Dane Salazar; Alexander W. Aleem; Jay D. Keener

BACKGROUND This study describes the short-term functional and radiographic outcomes after total shoulder arthroplasty (TSA) in shoulders with a B2 glenoid deformity addressed with corrective reaming. METHODS We conducted a retrospective series of consecutive patients who underwent TSA with a Walch B2 glenoid quantified by computed tomography scan. All glenoid deformities were addressed using partially corrective glenoid reaming. Radiographic and functional outcome measures, including scores on the visual analog scale for pain, American Shoulder and Elbow Standardized Shoulder Assessment, and Simple Shoulder Test were collected. RESULTS Functional outcome scores were available for 59 of 92 eligible subjects (64%) at a mean of 50 months. The mean preoperative retroversion measured 18° (range, -1° to 36°), superior inclination was 8° (range, -11° to 27°), and posterior subluxation was 67% (range, 39%-91%). Mean visual analog scale improved from 7.4 to 1.4, the American Shoulder and Elbow Shoulder Standardized Assessment improved from 35.4 to 84.3, and the SST improved from 4.5 to 9.1. Radiographs were evaluated at a mean of 31 months: 38 had no glenoid radiolucent lines, 13 glenoids had grade 1, 2 had grade 2, and 5 had grade 3 lucencies. There was no difference in the rate of progression of glenoid radiolucencies between shoulders with a preoperative glenoid version of ≤20° (27.8%) compared with glenoids with >20° of retroversion (22.7%, P = .670). No shoulders were revised due to glenoid loosening or instability. CONCLUSION TSA with partial corrective glenoid reaming in selected shoulders with a B2 glenoid deformity resulted in excellent functional and radiographic outcomes at short-term follow-up, with a low risk of revision surgery.


Journal of Shoulder and Elbow Surgery | 2018

Correlation of Patient-Reported Outcomes Measurement Information System (PROMIS) scores with legacy patient-reported outcome scores in patients undergoing rotator cuff repair

Brendan M. Patterson; Nathan D. Orvets; Alexander W. Aleem; Jay D. Keener; Ryan P. Calfee; Devon C. Nixon; Aaron M. Chamberlain

BACKGROUND The Patient-Reported Outcomes Measurement Information System (PROMIS) is being used to assess outcomes in many patient populations despite limited validation. The purpose of this study was to investigate the relationship between American Shoulder and Elbow Surgeons (ASES) and Simple Shoulder Test (SST) scores and PROMIS Physical Function (PF) and Upper Extremity (UE) function scores collected preoperatively in patients undergoing rotator cuff repair. METHODS This cross-sectional study analyzed 164 consecutive patients undergoing arthroscopic rotator cuff repair. Study inclusion required preoperative completion of the ASES and SST evaluations, as well as the PROMIS PF, UE, and Pain Interference computerized adaptive tests. Descriptive statistics were produced, and Pearson correlation coefficients were calculated between each of the outcome measures. RESULTS Average PROMIS UE scores indicated greater impairment than PROMIS PF scores (34 vs 44). Three percent of patients reached the PROMIS UE ceiling score of 56. PROMIS PF scores demonstrated a weak correlation with ASES scores (r = 0.43, P < .001) and a moderate correlation with SST scores (r = 0.51, P < .001). PROMIS UE scores demonstrated a moderate correlation with both ASES scores (r = 0.59, P < .001) and SST scores (r = 0.62, P < .001). PROMIS Pain Interference scores demonstrated weak negative correlations with both ASES scores (r = -0.43, P < .001) and SST scores (r = -0.41, P < .001). Patients answered fewer questions on average using the PROMIS PF and UE instruments as compared with the ASES and SST instruments. CONCLUSION PROMIS UE scores indicate greater impairment and demonstrate a stronger correlation with the legacy shoulder scores than PROMIS PF scores in patients with symptomatic rotator cuff tears. PROMIS computerized adaptive tests allow for more efficient patient-reported outcome data collection compared with traditional outcome scores.


Journal of Shoulder and Elbow Surgery | 2018

Do magnetic resonance imaging and computed tomography provide equivalent measures of rotator cuff muscle size in glenohumeral osteoarthritis

Peter N. Chalmers; Lindsay Beck; Irene Stertz; Alexander W. Aleem; Jay D. Keener; Heath B. Henninger; Robert Z. Tashjian

BACKGROUND Rotator cuff muscle volume is associated with outcomes after cuff repair and total shoulder arthroplasty. Muscle area on select magnetic resonance imaging (MRI) slices has been shown to be a surrogate for muscle volume. The purpose of this study was to determine whether computed tomography (CT) provides an equivalent measurement of cuff muscle area to a previously validated MRI measurement. METHODS We included 30 patients before they were undergoing total shoulder arthroplasty with both preoperative CT and MRI scans performed within 30 days of one another at 1 institution using a consistent protocol. We reoriented CT sagittal and MRI sagittal T1 series orthogonal to the scapular plane. On both CT and MRI scans, we measured the area of the supraspinatus, infraspinatus-teres minor, and subscapularis on 2 standardized slices as previously described. We calculated intraclass correlation coefficients and mean differences. RESULTS For the 30 subjects included, when MRI and CT were compared, the mean intraclass correlation coefficients were 0.989 (95% confidence interval [CI], 0.976-0.995) for the supraspinatus, 0.978 (95% CI, 0.954-0.989) for the infraspinatus-teres minor, and 0.977 (95% CI, 0.952-0.989) for the subscapularis. The mean differences were 0.2 cm2 (95% CI, 0.0-0.4 cm2) for the supraspinatus (P = .052), 0.8 cm2 (95% CI, 0.1-1.4 cm2) for the infraspinatus-teres minor (P = .029), and -0.3 cm2 (95% CI, -1.2 to 0.5 cm2) for the subscapularis (P = .407). CONCLUSION CT provides nearly equivalent measures of cuff muscle area to an MRI technique with previously validated reliability and accuracy. While CT underestimates the infraspinatus area as compared with MRI, the difference is less than 1 cm2 and thus likely clinically insignificant.


Journal of Shoulder and Elbow Surgery | 2018

Optimizing reverse shoulder arthroplasty component position in the setting of advanced arthritis with posterior glenoid erosion: a computer-enhanced range of motion analysis

Jay D. Keener; Brendan M. Patterson; Nathan D. Orvets; Alexander W. Aleem; Aaron M. Chamberlain

BACKGROUND Our study purpose was to determine the optimal glenoid and humeral reverse shoulder arthroplasty (RSA) component design and position in osteoarthritic shoulders with severe glenoid retroversion deformities. METHODS Computed tomography scans from 10 subjects were analyzed with advanced software including RSA range of motion (ROM) analysis. Variables included glenoid component retroversion of 0°, 5°, 10°, 15°, and 20° and baseplate lateralization of 0, 5, and 10 mm. Humeral variables included 135°, 145°, and 155° angle of inclination (AOI) combined with variable humeral offset. RESULTS Glenoid component lateralization had the greatest influence on ROM. In comparing each ROM direction among all lateralization options independently, there were significantly greater adduction, abduction, external rotation, extension, and flexion motions with progressively greater lateralization. Internal rotation motion was greater at 10 mm only. In analyzing the effects of glenoid version independently, no differences in adduction or abduction ROM were seen. With greater retroversion, decreased external rotation and extension motion was noted; however, greater internal rotation and flexion motion was seen with the exception of flexion at 10 mm of lateralization. For adduction, external rotation, and extension, a more valgus AOI resulted in less ROM at each progressively greater AOI independent of humeral lateralization. Internal rotation and flexion motions were greater with a more varus AOI but not significant between each inclination angle. Abduction ROM was maximized with a more valgus AOI. Humeral lateralization had no effect on ROM. CONCLUSIONS In the setting of RSA for advanced glenoid osteoarthritic deformities, optimal ROM is achieved with 10-mm baseplate lateralization and neutral to 5° of retroversion mated to a humeral implant with a varus (135°) inclination angle.


Journal of Shoulder and Elbow Surgery | 2018

Neer Award 2018: the effect of preoperative education on opioid consumption in patients undergoing arthroscopic rotator cuff repair: a prospective, randomized clinical trial

Usman Ali M. Syed; Alexander W. Aleem; Charles Wowkanech; Danielle Weekes; Mitchell Freedman; Fotios P. Tjoumakaris; Joseph A. Abboud; Luke Austin

BACKGROUND Opioids are commonly administered for the treatment of acute and chronic pain symptoms. The current health care system is struggling to deal with increasing medication abuse and rising mortality rates from overdose. Preoperative patient-targeted education on opioid use is an avenue yet to be explored. The purpose of the study was to determine whether preoperative narcotics education reduces consumption after arthroscopic rotator cuff repair (ARCR). METHODS Patients undergoing primary ARCR at our institution were randomized to receiving opioid-related preoperative education or not. Patients filled out preoperative questionnaires detailing complete medical history and visual analog scale (VAS) for pain. Patients completed questionnaires regarding their opioid consumption and pain at their 2-week, 6-week, and 3-month follow-up. RESULTS The study enrolled 140 patients. Patients in the study group consumed significantly less narcotics than the control group at the 3-month follow-up. Patients in the education group were 2.2 times more likely to discontinue narcotic use by the end of follow-up (odds ratio, 2.19; P = .03). In addition, patients with a history of preoperative narcotic use that were in the education group were 6.8 times more likely to discontinue narcotics by the end of follow-up (odds ratio, 6.8; P = .008). DISCUSSION/CONCLUSIONS The findings of this study determined that preoperative education intervention significantly decreased the number of narcotic pills consumed at 3 months after ARCR. In addition, education resulted in earlier cessation of opioids; therefore, directed patient education can help alleviate the current opioid epidemic.

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Joseph A. Abboud

Thomas Jefferson University

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Jay D. Keener

Washington University in St. Louis

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Ryan P. Calfee

Washington University in St. Louis

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Usman Ali M. Syed

Thomas Jefferson University

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Charles A. Goldfarb

Washington University in St. Louis

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Justin D. Krogue

Washington University in St. Louis

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Leesa M. Galatz

Icahn School of Medicine at Mount Sinai

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Luke Austin

Thomas Jefferson University

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Nathan D. Orvets

Washington University in St. Louis

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