Anas Lataifeh

Core–Shell Nanoparticles Containing Peptide Dendrimers

Dealloying of bimetallic gold core–silver shell nanoparticles (NPs) is achieved using peptide dendrimers from generation 1 to generation 3. The resulting NPs exhibit optical properties characteristic of Au/Ag core–shell NPs with weak surface plasmon resonance interactions between the core and shell. Transmission electron microscopy and x-ray photoelectron spectroscopy of the core–shell NPs exhibit a size and composition dependence on the dendrimer generation number. Rutherford backscattering spectrometric analyses of core–shell NPs containing dendrimer innerlayer indicates that the NPs are consisting of discrete domains of Ag–shell and Au–core.

Bivariate Calibration Method vs. HPLC and Derivative Spectroscopy for Simultaneous Determination of Binary Drugs in Pharmaceutical Formulations: A study on Prifinium Bromide/Paracetamol and Amoxicillin/Potassium Clavulanate

Abstract Bivariate analysis method has been applied to quantify binary combination of prifinium bromide/paracetamol and amoxicillin/potassium clavulanate. The method was tested for linearity, recovery, specificity and was found fast, precise, and free from interferences. The elaborated method for the two combinations was compared to validated HPLC-UV methods. The bivariate assay was used to quantify prifinium bromide/paracetamol and amoxicillin/potassium clavulanate in drug formulation samples. The results are in good agreement of the labeled contents. Statistical analysis using students t-test and F-test showed no significant differences between the results obtained by bivariate method and HPLC method in commercial drug samples. The bivariate method is simple, time saving, sensitive, and versatile and could effectively be an alternative method to HPLC.

Development and Validation of HPLC Method for Simultaneous Quantification of Prifinium Bromide/Paracetamol Combination in Pharmaceutical Formulations

A simple, rapid, accurate and precise HPLC method was developed and validated for the simultaneous quantification of prifinium bromide and paracetamol combination in pharmaceutical dosage form. The separation was achieved on a normal phase-nitrile (CN) column. The mobile phase consisted of 30 mM ammonium acetate buffer–acetonirtile (50%:50%, v/v) at pH = 6.5. The UV detection was carried out at a wavelength of 254 nm. A linear response was observed over a concentration range 3–50 μg/mL for prifinium bromide and paracetamol. The limit of detection for prifinium bromide was 0.75 μg/mL and its limit of quantification was 2.30 μg/mL. For paracetamol, the limit of detection was 0.64 μg/mL while its limit of quantification was 1.60 μg/mL. The method was validated for linearity, accuracy, precision and robustness. The validated method was applied to the analysis of prifinium bromide and paracetamol in commercial Riabal ® Compound tablets.

Isopropyl N-[1'-(methoxy-carbon-yl)ferro-cen-yl]carbamate-ethyl N-[1'-(methoxy-carbon-yl)ferrocen-yl]carbamate (0.6/0.4).

Herein we report the crystal structure and synthesis of two cocrystallized complexes, [Fe(C7H7O2)(C9H12NO2)]0.6[Fe(C7H7O2)(C8H10NO2)]0.4. The molecules crystallize as layers in the bc plane with van der Waals interactions allowing the alkyl chains to interact and the ferrocene units to form a herringbone pattern up the c axis. Every second layer is linked via N—H⋯O hydrogen bonding.The two complexes were modelled as disordered in a ratio of 0.60:0.40.