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Dive into the research topics where André O. Werneck is active.

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Featured researches published by André O. Werneck.


Childhood obesity | 2016

Biological Maturation, Central Adiposity, and Metabolic Risk in Adolescents: A Mediation Analysis

André O. Werneck; Danilo Rodrigues Pereira da Silva; Paul J. Collings; Rômulo Araújo Fernandes; Enio Ricardo Vaz Ronque; Décio Sabbatini Barbosa; Edilson Serpeloni Cyrino

BACKGROUND Earlier biological maturation has been related to increased metabolic risk. In this study, we verified mediating effects by central adiposity of the relationship between somatic maturity and metabolic risk factors in adolescents. METHODS In a cross-sectional study, 1034 adolescents aged 10-16 years from Londrina/PR/Brazil were evaluated. The age of peak height velocity (PHV) method was used to evaluate somatic maturity. Central adiposity was estimated through waist circumference measurements. Fasting glucose, triglycerides, high-density lipoprotein cholesterol (HDL-C), and blood pressure were measured as metabolic risk indicators. Physical activity (Baecke questionnaire) and cardiorespiratory fitness (20-m shuttle run test) were used as covariates. RESULTS Except for fasting glucose, waist circumference showed partial or full mediation of the relationship between maturity and the following metabolic risk factors with their respective z-score values: triglycerides (boys = -3.554 vs. girls = -5.031), HDL-C (boys = +5.300 vs. girls = +5.905), systolic blood pressure (boys = -3.540 vs. girls = -3.763), diastolic blood pressure (boys = -2.967 vs. girls = -3.264), and metabolic risk score (boys = -5.339 vs. girls = -6.362). CONCLUSIONS The results suggest that central obesity plays a mediating role in the relationship between somatic maturation and metabolic risk during adolescence.


American Journal of Human Biology | 2016

Cardiorespiratory fitness is related to metabolic risk independent of physical activity in boys but not girls from Southern Brazil

Danilo Rodrigues Pereira da Silva; André O. Werneck; Paul J Collings; Crisieli M. Tomeleri; Rômulo Araújo Fernandes; Enio Ricardo Vaz Ronque; Danielle Venturini; Décio Sabbatini Barbosa; Manuel J. Coelho-e-Silva; Luís B. Sardinha; Edilson Serpeloni Cyrino

Our aim was to determine the relationship between cardiorespiratory fitness (CRF) and metabolic risk in adolescents from Southern Brazil.


Journal of Developmental Origins of Health and Disease | 2017

Birth weight, biological maturation and obesity in adolescents: a mediation analysis

André O. Werneck; Danilo Rodrigues Pereira da Silva; Paul J Collings; Rômulo Araújo Fernandes; Enio Rv Ronque; Manuel J. Coelho-e-Silva; Luís B. Sardinha; Edilson Serpeloni Cyrino

This study was aimed to investigate associations between birth weight and multiple adiposity indicators in youth, and to examine potential mediating effects by biological maturation. This was a school-based study involving 981 Brazilian adolescents aged between 10 and 17 years. Birth weight was reported retrospectively by mothers. Maturation was estimated by age of peak height velocity. Adiposity indicators included body mass index (BMI), waist circumference and percent body fat estimated from triceps and subscapular skinfolds. Multilevel mediation analyses were performed using the Sobel test, adjusted for chronological age, gestational age, cardiorespiratory fitness and socio-economic status. Except for body fat in girls, biological maturation partly or fully mediated (P<0.05) positive relationships between birth weight with all other obesity indicators in both sexes with their respective values of indirect effects with 95% confidence intervals: BMI [boys: 0.44 (0.06-0.82); girls: 0.38 (0.13-0.64)], waist circumference [boys: 1.14 (0.22-2.05); girls: 0.87 (0.26-1.48)] and body fat [boys: 0.60 (0.13-1.07)]. To conclude, birth weight is associated with elevated obesity risk in adolescence and biological maturation seems to at least partly mediate this relationship.


Journal of Clinical Hypertension | 2016

Correlates of Blood Pressure According to Early, On Time, and Late Maturation in Adolescents

André O. Werneck; Danilo Rodrigues Pereira da Silva; Mariana F. Souza; Diego Giulliano Destro Christofaro; Crisieli M. Tomeleri; Rômulo Araújo Fernandes; Enio Ricardo Vaz Ronque; Manuel J. Coelho-e-Silva; Luís B. Sardinha; Edilson Serpeloni Cyrino

The aim of this study was to estimate the prevalence and correlates of blood pressure (BP) according to somatic maturation in Southern Brazilian adolescents. A total of 1321 adolescents participated in the study (732 girls), aged between 10 and 16 years, enrolled in public schools. The assessment of BP was performed using oscillometric equipment. Measurements of body weight, height, waist circumference, and skinfold thickness were performed. Somatic maturation was estimated by the age at peak height velocity. Behavioral and hereditary variables were obtained using a questionnaire. Early‐maturing adolescents had the highest prevalence of high BP (28%; 95% confidence interval, 24.6–33.5) compared with other maturational groups (P=.003). In late‐maturing adolescents, the variables associated with BP were paternal hypertension (systolic BP: β=4.9; diastolic BP: β=5.3) and early physical activity (systolic BP: β=−4.0; diastolic DBP: β=−3.6). In average‐maturing adolescents, waist circumference (systolic BP: β=0.3), body mass index (diastolic BP: β=0.5), and mothers hypertension (diastolic BP: β=1.8) were positively related to BP. In early‐maturing adolescents, only waist circumference (systolic BP: β=0.3; diastolic BP: β=0.3) was associated with BP. The authors conclude that the prevalence of high BP is greater in adolescents with early maturity and the outcome appears to be related to biological indicators in this group. On the other hand, in late‐maturing adolescents, behavioral and hereditary variables are more related to BP.


Annals of Human Biology | 2017

Cardiorespiratory fitness effect may be under-estimated in ‘fat but fit’ hypothesis studies

Danilo Rodrigues Pereira da Silva; André O. Werneck; Paul J. Collings; David Ohara; Rômulo Araújo Fernandes; Décio Sabbatini Barbosa; Enio Ricardo Vaz Ronque; Luís B. Sardinha; Edilson Serpeloni Cyrino

Abstract Background: Both cardiorespiratory fitness and body fat have been independently related to metabolic syndrome in adolescents; however, the strength of these relationships seems to be dependent on the outcome composition. Aim: To analyse the relationship between cardiorespiratory fitness and body fat combined with different indicators of metabolic risk in adolescents. Subjects and methods: The sample was composed of 957 adolescents (58.7% girls). Cardiorespiratory fitness was obtained using the 20-metre shuttle run test and skinfold thickness was collected for body fat estimation. Metabolic risk score was calculated from waist circumference, systolic and diastolic blood pressure, glucose, HDL cholesterol and triglycerides measurements and an alternative outcome without the central obesity indicator was adopted. Chronological age and somatic maturity were used as covariates. Results: Higher metabolic risk was observed in the highest fat/lowest fit adolescents (p < .05), regardless of sex and outcome. In the regression models, for full metabolic risk score, body fat presented higher coefficients compared to cardiorespiratory fitness in both sexes (boys: 0.501 vs −0.097; girls: 0.485 vs −0.087); however, in the metabolic risk without waist circumference, the coefficients became closer (boys: 0.290 vs −0.146; girls: 0.265 vs −0.120), with a concomitant decrease in body fat and increase in cardiorespiratory fitness coefficients. Conclusion: These findings suggest that body fat is strongly related to cardiovascular risk, but, when the outcome is calculated without the central obesity indicator, cardiorespiratory fitness becomes more related to metabolic risk.


Journal of Public Health | 2018

Physical activity maintenance and metabolic risk in adolescents

Danilo R. Silva; André O. Werneck; Paul J. Collings; Rômulo Araújo Fernandes; Décio Sabbatini Barbosa; Enio R V Ronque; Luís B. Sardinha; Edilson Serpeloni Cyrino

Aim Examine the association between child and adolescent physical activity maintenance categories and metabolic profile in adolescence. Methods This cross-sectional study was conducted with 1152 adolescents (57.4% female) aged 10-16 years from Londrina, Brazil. Physical activity was self-reported in childhood (7-10 years old, retrospective data) and adolescence through questionnaires. Cardiorespiratory fitness (20 m shuttle-run test), body fat (skinfolds), waist circumference, blood pressure (automatic instrument) and blood variables (fasting glucose, HDL-cholesterol and triglycerides) were measured at adolescence. Results Frequency of physical activity in childhood and adolescence was 50.3 and 17.2%, respectively, and only 25.7% of boys and 10.9% of girls were active at both ages. Adolescents who were physically active in childhood alone were less likely [OR = 0.71 (95% CI: 0.52-0.97)] to present low cardiorespiratory fitness in adolescence compared to those who were non-active in childhood. Regardless of controlled, actives in childhood and adolescence were less likely to present low cardiorespiratory fitness [OR = 0.50 (95% CI: 0.34-0.73)], high blood pressure [OR = 0.52 (95% CI: 0.32-0.85)] and high metabolic risk score [OR = 0.44 (95% CI: 0.22-0.90)] compared to the non-actives at both ages. Conclusions Actives through childhood to adolescence are less likely to present low cardiorespiratory fitness, high blood pressure and high metabolic risk.


Social Psychiatry and Psychiatric Epidemiology | 2018

Physical activity and depression: is 150 min/week of moderate to vigorous physical activity a necessary threshold for decreasing risk of depression in adults? Different views from the same data

André O. Werneck; Adewale L. Oyeyemi; Danilo R. Silva

Given the global burden of depression worldwide, studies on its correlates and determinants in different countries and population sub-groups tend to be encouraged to formulate effective public health policies. In this sense, an interesting paper was published in the September 9th 2017 edition of Social Psychiatry and Psychiatric Epidemiology. Although the relationship between physical activity and depression symptoms seems clear, Oliveira et al. [1] extended this to the South American context through data from the Brazilian National Health Survey conducted in 2013. Controlling for important covariates (age, gender, race, marital status, education and insurance status and depression-related comorbidities), the authors observed that young adults (18–39 years, YA), middle-aged adults (40–59 years, MAA) and older adults (60+ years, OA) males who did not achieve international physical activity recommendations of at least 150 min/week of moderate intensity physical activity or at least 75 min/week of vigorous intensity physical activity or a combination of both during leisure-time showed greater prevalence of depression compared to their physically active counterparts achieving these recommendations. However, the same association was not observed among women. The authors hypothesized that the potentially protective effects of leisure-time physical activity on depression in men but not in women may be explained by the physical activities performed in other domains (i.e., household chores and occupational activities) by women. Contrarily, we suggest that the higher prevalence of depression among women than men and other un-controlled variables (that affect both sexes differently) could explain the apparent lack of protective effects of sufficient leisure-time physical activity on depression in women. Moreover, due to the cross-sectional nature of the data, reverse association is also plausible. So, we could also assume that depressive men are less likely to be active compared to non-depressive men. However, regardless of the potential explanations, our concern is related to the potential public health message from the study. Thus, we were motivated to further explore these data to enhance the understanding of the topic and advance it public health message. We acknowledge the authors’ merit. This letter aims just to reflect on another perspective from the same data, considering reproducibility as a fundamental principle in science, especially in public-use data sets. To achieve this, we replicated the procedures exactly as described by Oliveira et al. [1] for the Brazilian National Health Survey 2013. Importantly, considering all of the criteria and variables used (exposure, outcome and covariates), we reproduced the same results found by Oliveira et al. However, while Oliveira et al. adopted meeting vs not meeting the international physical activity recommendation as the exposure, we opted to distinguish the inactives (0 min/ week) and actives but sub-guidelines (1–149 min/week) from the not meeting guidelines category, to understand the gradual relationships between physical activity and depression (Fig. 1). We found that not only to achieve 150 min/week of moderate to vigorous physical activity (MVPA), but even few amounts of weekly MVPA (1–74 min/week and 75–149 min/ week) were associated with lower prevalence of depression (especially for men). Whereas this gradual relationship was more linear in men, results for women were less clear (which aggregated to the Oliveira’s results), but lower prevalence of * André O. Werneck [email protected]


Revista Brasileira de Atividade Física & Saúde | 2018

Pattern of sedentary behavior in brazilian adolescents

Drielly Elvira Ramos; Maria Raquel de Oliveira Bueno; Lidyane Zambrin Vignadelli; André O. Werneck; Enio Ricardo Vaz Ronque; Manoel João Coelho-E-Silva; Marcelo Romanzini

The present study objectively measured the pattern of sedentary behavior among schoolchildren from a city in southern Brazil. A probabilistic sample composed of 394 adolescents was selected from ten public schools in the city of Londrina/PR. The cut-point of 720 counts.min-1 for the vector magnitude from the ActiGraph accelerometer was used to estimate the total sedentary time, bouts (1-4 min, 5-9 min, 10-14 min, 15-29 min, and ≥ 30 min), and breaks during the week, on weekdays and at weekends, as well as at school and out of school. Adolescents spent about 10 hours per day in sedentary behavior. Total sedentary time in bouts was 50% (278 from 535 minutes) in short bouts. Adolescents demonstrated greater time in shorter bouts (< 10 minutes) within the school period and longer time in extended bouts (≥ 15 minutes) outside school (p < 0.05). Sex and socioeconomic status had no effect on sedentary time regarding bouts and number of breaks. Thus, Brazilian adolescents present high levels of sedentary time, especially during time outside school.


PLOS ONE | 2018

Tracking of body adiposity indicators from childhood to adolescence: Mediation by BMI

Enio Ricardo Vaz Ronque; André O. Werneck; Maria Raquel de Oliveira Bueno; Edilson Serpeloni Cyrino; Luiz Cláudio Reeberg Stanganelli; Miguel de Arruda

Our aim was to verify the tracking of body adiposity indicators from childhood to adolescence and analyze the mediation effects of BMI on the stability of body adiposity. Our sample was composed by 375 children (197 boys). The children were followed-up over 3 years. Body mass and stature were measured as anthropometric indicators. Body adiposity was estimated through the subcutaneous skinfold method, with measures of triceps (TRSF) and subscapular skinfolds (SSSF). Skinfolds were analyzed singly and agglutinated through the sum of skinfolds (∑SF). The sample was categorized into tertiles, and thereafter, the kappa coefficient and McNemar test were adopted to verify stability. For continuous measures, the Intra-Class Correlation coefficient (ICC) was used. Moreover, mediation analyzes were used according to Baron and Kenny with the Sobel test to verify mediation effects. The significance level adopted was 5%. Adiposity indicators increased during the 3 years of follow-up in both sexes (p<0.05). ICCs in all indicators of adiposity were between 0.84 and 0.94 for boys and 0.86 and 0.94 for girls, indicating high tracking. Moreover, 70% of subjects remained in the highest tertile of body adiposity. However, no differences were observed in tertile changes (p>0.05). BMI at the age of adiposity rebound partially mediated all indicators of adiposity from childhood (baseline) to adolescence (3 years later) in both sexes (p<0.001). Thus, moderate to high tracking of body adiposity indicators between childhood and adolescence was verified. Moreover, BMI at the age of adiposity rebound partially mediated the relationship between adiposity in childhood (baseline) and in adolescence (3 years of follow-up).


Journal of Clinical Hypertension | 2018

Does leisure-time physical activity attenuate or eliminate the positive association between obesity and high blood pressure?

André O. Werneck; Adewale L. Oyeyemi; Aline Mendes Gerage; Edilson Serpeloni Cyrino; Célia Landmann Szwarcwald; Luís B. Sardinha; Danilo R. Silva

We examine the joint association of weight status and leisure‐time physical activity on high blood pressure in a nationally representative sample of adults and older adults in Brazil. This was a national cross‐sectional survey conducted in Brazil in 2013 (Brazilian Health Survey). The sample consisted of 59 402 participants (56% women, aged 18 to 100 years). Outcome was objectively assessed blood pressure. Body mass index (BMI) was objectively measured, while self‐reported information on leisure‐time physical activity, TV viewing, chronological age, race, educational status, tobacco smoking, sodium consumption, and hypertension medication was obtained using questionnaires. Logistic regression analysis with adjusted odds ratio was conducted to test the joint association of BMI and leisure‐time physical activity categories on high blood pressure. Overall, compared to normal weight (NW) and physically active group, the NW/inactive (OR = 1.28; 1.04 to 1.58), overweight/active (OR = 1.38; 1.08 to 1.78), overweight/inactive (OR = 1.89; 1.53 to 2.33), obese/active (OR = 2.19; 1.59 to 3.01) and obese/inactive (OR = 2.54; 2.05 to 3.15) groups were 28% to 254% more likely to have high blood pressure. The attenuation and high blood pressure was greater for women and adults than for men and older adults. Thus, leisure‐time physical inactivity and being overweight and obesity were associated with high blood pressure in Brazilian population. Engaging in sufficient level of physical activity during leisure could attenuate, but not eliminate, the negative influence of obesity on high blood pressure in Brazilian adults and older adults.

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Edilson Serpeloni Cyrino

Universidade Estadual de Londrina

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Enio Ricardo Vaz Ronque

Universidade Estadual de Londrina

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Danilo R. Silva

Universidade Federal de Sergipe

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Décio Sabbatini Barbosa

Universidade Estadual de Londrina

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