Andrew Ott

Atomic layer deposition of SiO2 using catalyzed and uncatalyzed self-limiting surface reactions

SiO2 thin films were deposited with atomic layer control using self-limiting surface reactions. The SiO2 growth was achieved by separating the binary reaction SiCl4+2H2O→ SiO2+4HCl into two half-re...

NHC-Catalyzed Reactions of Aryloxyacetaldehydes: A Domino Elimination/Conjugate Addition/Acylation Process for the Synthesis of Substituted Coumarins

N-heterocyclic carbenes (NHCs) catalyze a domino Michael addition/acylation reaction to form 3,4-dihydrocoumarins. The reaction proceeds through addition of the NHC to an aryloxyaldehyde followed by elimination of a phenoxide leaving group, generating an enol intermediate. This transient nucleophile generated in situ performs a 1,4-addition onto a conjugate acceptor, and the carbene catalyst is regenerated upon acylation of the phenoxide anion resulting in formation of 3,4-dihydrocoumarins.