Anjum Muzaffar

Salvadoricine: a new indole alkaloid from the leaves of Salvadora persica

A new indole alkaloid salvadoricine (I) has been isolated from Salvadora Persica. Its structure was elucidated by spectral analysis and confirmed by synthesis. This constitutes the first report of naturally occuring 3-acetylindole alkaloid.

Stapfinine, an indole alkaloid from Ervatamia coronaria

A new indole alkaloid, stapfinine, was isolated from the leaves of Ervatamia coronaria and its structure determined by spectroscopic means.

Saifine and N-methylleuconolam, New Indole Alkaloids from Rhazya Stricta

Abstract A novel alkaloid “saifine” having an aspidosperma- type skeleton has been isolated from the roots of Rhazya stricta, along with N-methylleuconolam, a new rhazinilam type indole alkaloid. The structures of the alkaloids were established on the basis of spectroscopic studies.

Alkaloids of Petchia ceylanica

Abstract A new alkaloid, petchicine, has been isolated from the stem bark of Petchia ceylanica and its structure was established by spectroscopic studies. The 13C NMR spectra of ajmalicinine, cabucine and fluorocarpamine, which have been isolated from the stem bark of Petchia ceylanica for the first time, are also reported.

Notizen: The Isolation and Structure of Lahoricine, a New Indolenine Alkaloid from Ervatamia coronaria

A new indolenine alkaloid, “Lahoricine” has been isolated from the leaves of Ervatamia coronaria to which structure 1 has been assigned.

Strictigine - A Novel 4-Vinylquinoline Alkaloid from Rhazya stricta

Abstract A novel 4-vinylquinoline alkaloid, strictigine, has been isolated from the roots, stems and leaves of Rhazya stricta. The structure of strictigine (1) was established with the help of spectroscopic studies including HOHAHA and inverse NMR experiments (HMQC, HMBC)

The Isolation and Structure of Mehranine, a New Indoline Alkaloid from Ervatamia coronaria

A new indoline alkaloid, mehranine, has been isolated from the leaves of Ervatamia coronaria to which structure 1 has been assigned

Chapter 2 Steroidal Alkaloids of Apocynaceae and Buxaceae

Publisher Summary This chapter deals with recent advances made in the field of steroidal alkaloids of Apocynaceae and Buxaceae. Steroidal alkaloids of Apocynaceae are conveniently classified into three main structural groups: the conanine group, the pregnane group, and the paravallarine group. Amino-glyco-steroids represent a new class of glyco-alkaloids in which an amino-sugar is linked to a steroidal unit. When the amino-sugar is attached to a cardenolide, then the substances are known as amino-glyco-cardenolides. The alkaloids of Buxaceae are regarded as derivatives of 9β,19-cyclo- and 9(10→19)-abeo-pregnane and are further subdivided according to the number of nitrogen atoms incorporated. Isolation and structure elucidation of these groups have been presented along with their mass spectroscopy analysis. The configuration and conformation of steroidal amino alcohols may be ascertained by chemical ionization mass spectrometry. The chapter also presents syntheses and chemical transformations of steroidal alkaloids. Biosynthesis and pharmacology of these alkaloids are also presented. The early suggestions concerned with the biosynthesis of Apocynaceae and Buxaceae alkaloids involved the intermediacy of 3- or 20-ketones bearing the sterol or triterpene skeleton.