Khurshid Zaman

Medicinal plants with hypoglycemic activity

This review summarises the literature on the antidiabetic activity of 343 medicinal plants reputed in the indigenous system of medicine or in which the pharmacological activity has been scientifically demonstrated. The data are presented in tabular form. The table reflects the plant parts involved, the nature of the extracts used and the names of the active principles with their structures where known. The pharmacological activities of some of the extracts or of the active principles isolated from these plants are also described.

Alkaloids from Rhazya stricta

Abstract Chemical investigations of roots and leaves of Rhazya stricta have resulted in the isolation of the new indole alkaloids, 16 R -19,20- E -isositsirikine acetate, leepacine and dihydroeburnamenine, along with six known alkaloids. Among these, (−)-16 R ,21 R - O -methyleburnamine, 2-ethyl-3[2-(3-ethylpiperidino)ethyl]-indole, (20 S )-19,20-dihydrocondylocarpine and N -acetylaspidospermidine have been isolated for the first time from R. stricta . Spectral studies on (+)-21 S -eburnamenine and the glycoalkaloid strictosamide have also been undertaken.

Studies on the alkaloids of Rhazya stricta

Abstract Two new dimeric indole alkaloids, 16 S ,16′-decarbomethoxytetrahydrosecamine ( 1 ) and 16 R ,16′-decarbomethoxytetrahydrosecamine ( 2 ) hav

Macroxine-A novel oxindole alkaloid from Alstonia macrophylla

Abstract A novel oxindole alkaloid macroxine (1) has been isolated from the leaves of Alstonia macrophylla and its structure was established on the basis of 1D and 2D NMR experiments including HOHAHA, HMQC and HMBC measurements. It is the first member of a new class of oxindole alkaloids.

1,2-dehydroaspidospermidine-N-oxide, an alkaloid from Rhazya stricta

Abstract A new alkaloid, 1,2-dehydroaspidospermidme- N -oxide, has been isolated from the roots of Rhazya stricta .

Saifine and N-methylleuconolam, New Indole Alkaloids from Rhazya Stricta

Abstract A novel alkaloid “saifine” having an aspidosperma- type skeleton has been isolated from the roots of Rhazya stricta, along with N-methylleuconolam, a new rhazinilam type indole alkaloid. The structures of the alkaloids were established on the basis of spectroscopic studies.

Strictigine - A Novel 4-Vinylquinoline Alkaloid from Rhazya stricta

Abstract A novel 4-vinylquinoline alkaloid, strictigine, has been isolated from the roots, stems and leaves of Rhazya stricta. The structure of strictigine (1) was established with the help of spectroscopic studies including HOHAHA and inverse NMR experiments (HMQC, HMBC)