Anthony J. Walton

Scuba-2: The 10 000 pixel bolometer camera on the james clerk maxwell telescope

SCUBA-2 is an innovative 10000 pixel bolometer camera operating at submillimetre wavelengths on the James Clerk Maxwell Telescope (JCMT). The camera has the capability to carry out wide-field surveys to unprecedented depths, addressing key questions relating to the origins of galaxies, stars and planets. With two imaging arrays working simultaneously in the atmospheric windows at 450 and 850µm, the vast increase in pixel count means that SCUBA-2 maps the sky 100–150 times faster than the previous SCUBA instrument. In this paper we present an overview of the instrument, discuss the physical characteristics of the superconducting detector arrays, outline the observing modes and data acquisition, and present the early performance figures on the telescope. We also showcase the capabilities of the instrument via some early examples of the science SCUBA-2 has already undertaken. In February 2012, SCUBA-2 began a series of unique legacy surveys for the JCMT community. These surveys will take 2.5years and the results are already providing complementary data to the shorter wavelength, shallower, larger-area surveys from Herschel. The SCUBA-2 surveys will also provide a wealth of information for further study with new facilities such as ALMA, and future telescopes such as CCAT and SPICA.

A yield improvement technique for IC layout using local design rules

The concept of local design rules is introduced. These are integrated circuit (IC) layout rules that define the optimum feature size and spacing in relation to the surrounding geometry and are used to increase the yield of ICs. The impact of these rules on the performance and reliability of ICs is discussed. Algorithms that enable the automatic application of track displacement, track width, and contact size local design rules to IC layout are presented. Simulation results are provided for some layout examples. >

Moving-part-free microfluidic systems for lab-on-a-chip

Microfluidic systems are part of an emerging technology which deals with minute amounts of liquids (biological samples and reagents) on a small scale. They are fast, compact and can be made into a highly integrated system to deliver sample purification, separation, reaction, immobilization, labelling, as well as detection, thus are promising for applications such as lab-on-a-chip and handheld healthcare devices. Miniaturized micropumps typically consist of a moving-part component, such as a membrane structure, to deliver liquids, and are often unreliable, complicated in structure and difficult to be integrated with other control electronics circuits. The trend of new-generation micropumps is moving-part-free micropumps operated by advanced techniques, such as electrokinetic force, surface tension/energy, acoustic waves. This paper reviews the development and advances of relevant technologies, and introduces electrowetting-on-dielectrics and acoustic wave-based microfluidics. The programmable electrowetting micropump has been realized to dispense and manipulate droplets in 2D with up to 1000 addressable electrodes and electronics built underneath. The acoustic wave-based microfluidics can be used not only for pumping, mixing and droplet generation but also for biosensors, suitable for single-mechanism-based lab-on-a-chip applications.

Development of immunosensors for direct detection of three wound infection biomarkers at point of care using electrochemical impedance spectroscopy

A method for label-free, electrochemical impedance immunosensing for the detection and quantification of three infection biomarkers in both buffer and directly in the defined model matrix of mock wound fluid is demonstrated. Triggering Receptor-1 Expressed on Myeloid cells (TREM-1) and Matrix MetalloPeptidase 9 (MMP-9) are detected via direct assay and N-3-oxo-dodecanoyl-l-HomoSerineLactone (HSL), relevant in bacterial quorum sensing, is detected using a competition assay. Detection is performed with gold screen-printed electrodes modified with a specific thiolated antibody. Detection is achieved in less than 1h straight from mock wound fluid without any extensive sample preparation steps. The limits of detection of 3.3 pM for TREM-1, 1.1 nM for MMP-9 and 1.4 nM for HSL are either near or below the threshold required to indicate infection. A relatively large dynamic range for sensor response is also found, consistent with interaction between neighbouring antibody-antigen complexes in the close-packed surface layer. Together, these three novel electrochemical immunosensors demonstrate viable multi-parameter sensing with the required sensitivity for rapid wound infection detection directly from a clinically relevant specimen.

Critical area extraction for soft fault estimation

Algorithms are presented for extracting the critical area associated with extra and missing material soft faults of an integrated circuit from the mask layout. These algorithms have been implemented within the Edinburgh Yield Estimator (EYE) tool which permits efficient extraction of the critical area from an arbitrary mask layout. Accurate estimates of device critical area of even the largest devices can be obtained in a reasonable time using the sampling version of the tool. The application of these algorithms to defect related reliability is explored and results reported that compare the susceptibility to soft faults before and after layout modifications intended to enhance manufacturing yield. These results suggest that yield enhancement techniques can have a significant impact on defect-related device reliability.

Experimental and numerical investigation of acoustic streaming excited by using a surface acoustic wave device on a 128° YX-LiNbO3 substrate

This work uses a finite volume method to investigate three-dimensional acoustic streaming patterns produced by surface acoustic wave (SAW) propagation within microdroplets. A SAW microfluidic interaction has been modelled using a body force acting on elements of the fluid volume within the interaction area between the SAW and fluid. This enables the flow motion to be obtained by solving the laminar incompressible Navier–Stokes equations driven by an effective body force. The velocity of polystyrene particles within droplets during acoustic streaming has been measured and then used to calibrate the amplitudes of the SAW at different RF powers. The numerical prediction of streaming velocities was compared with the experimental results as a function of RF power and a good agreement was observed. This confirmed that the numerical model provides a basic understanding of the nature of 3D SAW/liquid droplet interaction, including SAW mixing and the concentration of particles suspended in water droplets.

The integration of simulation and response surface methodology for the optimization of IC processes

This paper describes a methodology that can be used for the optimization of semiconductor processes. This is achieved by integrating the design of experiments and Response Surface Methodology (RSM) with process and device simulation tools. Software for automating multiple simulations has been implemented and interfaced to RS/1 to assist in the manual design and analysis of experiments and the subsequent optimization procedures. The procedure is illustrated through the optimization of part of an MOS process with multi-parameter optimization being performed by the introduction of composite responses and sensitivity analysis. These simulated results are also compared with experimental measurements. >

Sheet resistance measurement of non-standard cleanroom materials using suspended Greek cross test structures

This paper presents work on the development, fabrication and characterization of a suspended Greek cross measurement platform that can be used to determine the sheet resistance of materials that would contaminate Complementary Metal Oxide Semiconductor (CMOS) processing lines. The arms of the test structures are made of polysilicon/silicon nitride (Si/sub 3/N/sub 4/) to provide a carrier for the film to be evaluated and thick aluminum (Al) probe pads for multiple probing. The film to be evaluated is simply blanket deposited onto the structures and because of its design automatically forms a Greek cross structure with (Al) probe pads. To demonstrate its use, 1) gold (Au), 2) copper (Cu), and 3) silver(Ag) loaded chalcogenide glass Ag/sub y/(Ge/sub 30/Se/sub 70/)/sub 1-y/ have been blanket evaporated in various thicknesses onto the platform in the last processing step and autopatterned by the predefined shape of the Greek crosses. The suspension of the platform ensured electrical isolation between the test structure and the surrounding silicon (Si) substrate. The extracted effective resistivity for Au (5.1/spl times/10/sup -8/ /spl Omega//spl middot/m), Cu (1.8- 2.5/spl times/10/sup -8//spl bsol/ /spl Omega//spl middot/m) and Ag/sub y/(Ge/sub 30/Se/sub 70/)/sub 1-y/ (2.27/spl times/10/sup -5/ /spl Omega//spl middot/m-1.88 /spl Omega//spl middot/m) agree with values found in articles in the Journal of Applied Physics (1963), the Journalof Physics D: Applied Physics (1976), and the Journalof Non-Crystalline Solids (2003). These results demonstrate that the proposed Greek cross platform is fully capable to measure the sheet resistance of low (Au, Cu) and high Ag/sub y/(Ge/sub 30/Se/sub 70/)/sub 1-y/ resistive materials.

Hierarchical critical area extraction with the EYE tool

A software tool to extract critical areas from commercial IC mask data is reported. The EYE (Edinburgh Yield Estimator) tool uses fast O(NlogN) critical area algorithms and is able to perform operations hierarchically making it suitable for use on large devices. The tool has applications in yield prediction, optimising the manufacturability of IC layout, and the generation of defect sensitivity visualisation aids in the form of fault probability maps.

Fluorescence Lifetime Imaging of Quantum Dot Labeled DNA Microarrays

Quantum dot (QD) labeling combined with fluorescence lifetime imaging microscopy is proposed as a powerful transduction technique for the detection of DNA hybridization events. Fluorescence lifetime analysis of DNA microarray spots of hybridized QD labeled target indicated a characteristic lifetime value of 18.8 ns, compared to 13.3 ns obtained for spots of free QD solution, revealing that QD labels are sensitive to the spot microenvironment. Additionally, time gated detection was shown to improve the microarray image contrast ratio by 1.8, achieving femtomolar target sensitivity. Finally, lifetime multiplexing based on Qdot525 and Alexa430 was demonstrated using a single excitation-detection readout channel.