Antonio Rocamora

Neutrophilic eccrine hidradenitis in two neutropenic patients.

Neutrophilic eccrine hidradenitis is an uncommon, self-limited dermatosis with a variable clinical presentation. It seems to be due to chemotherapeutic drugs in most cases. Necrosis of the eccrine gland associated with a neutrophilic infiltrate is the histologic hallmark of this disease. We report two additional cases in neutropenic patients with acute myelogenous leukemia in which there was a striking lack of neutrophil infiltration. A new term, drug-associated eccrine hidradenitis, is suggested.

Infectious eccrine hidradenitis

I. Mitsuhashi Y, Hohl D.Dermatitis herpetiforrnis in a patient with acquired immunodeficiency syndrome-related complex [Letter]. J AM ACAD DERMATOL 1988;18:583. 2. Kaplan MH, Sadick, N, McNutt NS, et al. Dermatologic findings and manifestations of acquired immunodeficiency syndrome (AIDS). J AM ACAD DERMATOL 1987;16:485506. 3. Janier M. Manifestations cutanees du SIDA. Ann Dermatol Venereol 1987;114:1487-8. 4. Kotler DP, Gaetz HP, Lange M, et al. Enteropathy associated with the acquired immunodeficiency syndrome. Ann Intern Med 1984;101:421-8.

Vegetating iododerma with underlying systemic diseases: Report of three cases

Three patients with vegetating iododerma as a result of potassium iodide therapy are presented. The first patient had polyarteritis nodosa, the second had monoclonal gammopathy of undertermined significance, and the third had multiple myeloma. Vegetating iododerma probably represents an idiosyncratic response to iodides; patients with polyarteritis nodosa and paraproteinemias may be predisposed.

Hyperkeratosis of the nipple and areola in a patient with cutaneous T-cell lymphoma

A 57-year-old man with a 2-year history of recurrent generalized erythroderma noted hyperkeratotic and verrucous lesions on the nipples and areoias 4 m(jnths prior to admission. His past medical history was relevani because of primary hyperaldosteronism due to sufirarenal adenoma. He has been on treatment with spironolactone (TOO mg/d orally) for 2 years because he refused surgical treatment. Physical examination showed generalized extoliative erythroderma, bilateral inguinal and axillary lymphadenopathy, hyperkeratosis of the palms and soles, and verrucoushyperkeratotic and hyperpigmented lesions on the areoias extending to the nipples (Fig. 1). No hepatosplenomegaly was noted. An extensive workup showecJ a cutaneous T-cell lymphoma (CTCL) (T4N3MoBo). A skin biopsy of the areola revealed a lymphocytic infiltrate in the papillary dermis and atypical lymphoid cells showing epidermotropism, besides a prominent hyperkeratosis and papillomatosis (Figs. 2, 3). Treatment was performed with electron beam irradiation and teleroentgen x-ray therapy to the affected lymph nodes. There was a total disappearance of the cutaneous lesions, including those from the nipples and areoias.

Lichen planus-like eruption with esophageal involvement as a result of cyanamide

the skin with cis-diamminedichloroplatinum III and doxorubicin. Laryngoscope 1982;92:1298-9. 6. Luxenburg MN, Guthrie TH. Chemotherapy of the eyelid and periorbital tumors. Trans Am Ophthalmol Soc 1985; 83:162-80. 7. Wieman TJ, Shively EH, Woodcock TM. Responsiveness of metastatic basal cel! carcinoma to chemotherapy. Cancer 1983;52:1583-5. 8. Coker DD, Elias EG, Viravathana T, et al. Chemotherapy for metastatic basal cell carcinoma. Arch Dermatol 1983; 119:44-50. 9. Guthrie TH Jr, McElveen LJ, Porubsky ES, et al. Cisplatin and doxorubicin: an effective chemotherapy combination in the treatment ofadvanced basal cell and squamous cell carcinoma of the skin. Cancer 1985;55: 1629-32.

Systemic Lupus Erythematosus Appearing as an Urticarial Vasculitis

ABSTRACT: A patient with systemic lupus erythematosus presented with clinical and histologic feature of urticarial vasculitis, a systemic immune disorder of unknown origin. This could represent a subset of collagen vascular disease.

Sweat Gland Necrosis in Drug-Induced Coma: A Light and Direct Immunofluorescence Study

We report herein characteristic traumatic skin lesions with blisters and sweat gland necrosis in a case of drug‐induced coma in which direct immunofluorescence demonstrated deposits of immunoglobulin and C3 in dermal vessels. The significance of our direct immunofluorescence findings is discussed.

MYCOSIS FUNGOIDES WITH SIGNET-RING CELLS AND MONOCLONAL GAMMOPATHY

A 73‐year‐old white woman was admitted to our hospital for evaluation of a chronic dermatitis. Personal history was remarkable only for arterial hypertension and noninsulin‐dependent6 diabetes mellitus. Clinical and histopathologic findings were consistent with a diagnosis of mycosis fundoides (mf and staging procedures including bolld cell counts, serum biochemistry, urinalysis, bone marrow biopsy, Sé zary cell counts in peripheral bolld, computerized tomography (ct scans, abdominal ultrasonography, chest roentgenograms, serum protein electrophoresis, and immunoelectrophoresis disclosed normal or negative results (T2 N0 M0 B0).

Propyphenazone‐lnduced Serum Sickness

antibody formation or impaired macropbage phagocytic capacity bas been reported.^ In addition, it is known clinically tbat leprosy occasionally exacerbates during pregnancy. Therefore, it is likely tbat an impaired protective immunity against mycobacterial organisms might be responsible for exacerbation in this case as described. Cross-reactive immunity against various mycobacterial antigens sbould be clarified, and careful observation for tbe development of atypical mycobacterial infection should be considered during pregnancy, a temporary immunocompromised state.