Ashley Edward Fenwick
Pfizer
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Publication
Featured researches published by Ashley Edward Fenwick.
Bioorganic & Medicinal Chemistry Letters | 2012
Graham Lunn; Lee R. Roberts; Douglas James Critcher; Sara Douglas; Ashley Edward Fenwick; David Morris Gethin; Graham Goodwin; David H.J. Greenway; Sean D.W. Greenwood; Kim Thomas Hall; Martin Thomas; Stephen Thompson; David H. Williams; Gavin Wood; Andrew Wylie
3-Azabicyclo[3.1.0]hexane compounds were designed as novel achiral μ opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe the SAR of this class of opioid ligand, highlighting changes to the lead structure which led to compounds having picomolar binding affinity, selective for the μ receptor over δ and κ subtypes. Some subtleties of functional activity will also be described.
Archive | 2001
Bernard Joseph Banks; Douglas James Critcher; Ashley Edward Fenwick; David Morris Gethin; Stephen Paul Gibson; Graham Lunn
Archive | 2007
Jessica Boyle; Ashley Edward Fenwick; David Morris Gethin; Catherine Frances Mccusker
Archive | 2011
Timothy Allen Johnson; Ashley Edward Fenwick; Graham M. Kyne
Archive | 2014
Matthew Frank Brown; Ashley Edward Fenwick; Mark Edward Flanagan; Andrea J. Gonzales; Timothy Allan Johnson; Neelu Kaila; Mark J. Mitton-Fry; Joseph Walter Strohbach; Ruth E. Tenbrink; John David Trzupek; Rayomand Jal Unwalla; Michael L. Vazquez; Mihir D. Parikh
Archive | 2015
Matthew Frank Brown; Ashley Edward Fenwick; Mark Edward Flanagan; Andrea J. Gonzales; Timothy Allan Johnson; Neelu Kaila; Mark J. Mitton-Fry; Joseph Walter Strohbach; Ruth E. Tenbrink; John David Trzupek; Rayomand Jal Unwalla; Michael L. Vazquez; Mihir D. Parikh
Archive | 2017
Matthew Frank Brown; Ashley Edward Fenwick; Mark Edward Flanagan; Andrea J. Gonzales; Timothy Allan Johnson; Neelu Kaila; Mark J. Mitton-Fry; Joseph Walter Strohbach; Ruth E. Tenbrink; John David Trzupek; Rayomand Jal Unwalla; Michael L. Vazquez; Mihir D. Parikh
Archive | 2014
Matthew Frank Brown; Ashley Edward Fenwick; Mark Edward Flanagan; Andrea J. Gonzales; Timothy Allan Johnson; Neelu Kaila; Mark J. Mitton-Fry; Joseph Walter Strohbach; Ruth E. Tenbrink; John David Trzupek; Rayomand Jal Unwalla; Michael L. Vazquez
Archive | 2011
Timothy Allen Johnson; Ashley Edward Fenwick; Graham M. Kyne
Archive | 2007
Jessica Boyle; Ashley Edward Fenwick; David Morris Gethin; Catherine Frances Mccusker
