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Douglas James Critcher

Pfizer

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Publication

Featured researches published by Douglas James Critcher.

Bioorganic & Medicinal Chemistry Letters | 2012

SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives as μ opioid ligands.

Graham Lunn; Lee R. Roberts; Douglas James Critcher; Sara Douglas; Ashley Edward Fenwick; David Morris Gethin; Graham Goodwin; David H.J. Greenway; Sean D.W. Greenwood; Kim Thomas Hall; Martin Thomas; Stephen Thompson; David H. Williams; Gavin Wood; Andrew Wylie

3-Azabicyclo[3.1.0]hexane compounds were designed as novel achiral μ opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe the SAR of this class of opioid ligand, highlighting changes to the lead structure which led to compounds having picomolar binding affinity, selective for the μ receptor over δ and κ subtypes. Some subtleties of functional activity will also be described.

Archive | 2004

Antiparasitic terpene alkaloids

Nathan Anthony Logan Chubb; Douglas James Critcher; James John Eshelby; Graham Lunn; Andrew J. Rudge; Nigel Derek Arthur Walshe; Paul Heinrich Wiedenau; David H. Williams

Archive | 2005

N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides

Douglas James Critcher; Nigel Derek Arthur Walshe; Christelle Lauret

Archive | 2001

3-AZABICYCLO (3.1.0) HEXANE DERIVATIVES HAVING OPIOID RECEPTOR AFFINITY

Bernard Joseph Banks; Douglas James Critcher; Ashley Edward Fenwick; David Morris Gethin; Stephen Paul Gibson; Graham Lunn

Archive | 2001

Pyridazine endothelin antagonists

Bernard Joseph Banks; Anthony Logan Chubb; Douglas James Critcher; James John Eshelby; Darren John Schulz

Archive | 2001

New pyridazine endothelin antagonists

Bernard Joseph Banks; Anthony Logan Chubb; Douglas James Critcher; James John Eshelby; Darren John Schulz

Archive | 2007

COMBINATION OF 1-ARYL-4-CYCLOPROPYLPYRAZOLES WITH ANTHELMINTIC AGENT FOR PARASITIC INFESTATION

Denis Billen; Jessica Boyle; Douglas James Critcher; David Morris Gethin; Kim Thomas Hall; Graham M Kyne

Archive | 2006

Substituierte arylpyrazole zur verwendung gegen parasiten Substituted arylpyrazoles for use against parasites

Denis Billen; Jessica Boyle; Douglas James Critcher; David Morris Gethin; Kim Thomas Hall; Graham M Kyne

Archive | 2005

DERIVES DE 3-AZABICYCLO [3,1,0] HEXANE NOUVEAUX, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS LES CONTENANT

Bernard Joseph Banks; Douglas James Critcher; Ashley Edward Fenwick; David Morris Gethin; Stephen Paul Gibson

Archive | 2001

DERIVÉS DE 3-AZABICYCLO(3,1,0) HEXANE AYANT UNE AFFINITÉ POUR LES RÉCEPTEURS D'OPIOIDES.

Bernard Joseph Banks; David Morris Gethin; Douglas James Critcher; Stephen Paul Gibson; Ashley Edward Fenwick; Graham Lunn

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David Morris Gethin

Pfizer

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Bernard Joseph Banks

Pfizer

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James John Eshelby

Pfizer

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Darren John Schulz

Pfizer

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Ashley Edward Fenwick

Pfizer

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Graham Lunn

Pfizer

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Nathan Anthony Logan Chubb

Pfizer

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Stephen Paul Gibson

Pfizer

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Ivan Tommasini

Pfizer

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Kim Thomas Hall

Pfizer

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