David Morris Gethin
Pfizer
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Publication
Featured researches published by David Morris Gethin.
Chemical Communications | 2008
Stephanie Lauru; Nigel S. Simpkins; David Morris Gethin; Claire Wilson
Enantioselective synthesis of cyclopropylcarboxamides is possible by asymmetric metallation of prochiral starting cyclopropanes using s-BuLi-sparteine.
Bioorganic & Medicinal Chemistry Letters | 2012
Graham Lunn; Lee R. Roberts; Douglas James Critcher; Sara Douglas; Ashley Edward Fenwick; David Morris Gethin; Graham Goodwin; David H.J. Greenway; Sean D.W. Greenwood; Kim Thomas Hall; Martin Thomas; Stephen Thompson; David H. Williams; Gavin Wood; Andrew Wylie
3-Azabicyclo[3.1.0]hexane compounds were designed as novel achiral μ opioid receptor ligands for the treatment of pruritus in dogs. In this paper, we describe the SAR of this class of opioid ligand, highlighting changes to the lead structure which led to compounds having picomolar binding affinity, selective for the μ receptor over δ and κ subtypes. Some subtleties of functional activity will also be described.
Archive | 2002
Stephen Paul Gibson; Ivan Tommasini; David Morris Gethin; Richard Edward Armer
Archive | 1999
Richard Edward Armer; Christopher J. Dutton; David Morris Gethin; Stephen Paul Gibson; Julian Duncan Smith; Ivan Tommasini
Archive | 2006
Denis Billen; Nathan Anthony Logan Chubb; David Morris Gethin; Kim Thomas Hall; Lee Richard Roberts; Nigel Derek Arthur Walshe
Archive | 2001
Bernard Joseph Banks; Douglas James Critcher; Ashley Edward Fenwick; David Morris Gethin; Stephen Paul Gibson; Graham Lunn
Archive | 2007
Jessica Boyle; Ashley Edward Fenwick; David Morris Gethin; Catherine Frances Mccusker
Archive | 2008
Denis Billen; Nathan Anthony Logan Chubb; David Morris Gethin; Kim Thomas Hall; Lee Richard Roberts; Nigel Derek Arthur Walshe; キム・トマス・ホール; デイヴィッド・モリス・ゲシン; デニス・ビレン; ナイジェル・デレク・アーサー・ウォルシュ; ネイサン・アントニー・ローガン・チャブ; リー・リチャード・ロバーツ
Archive | 2007
Denis Billen; Jessica Boyle; Douglas James Critcher; David Morris Gethin; Kim Thomas Hall; Graham M Kyne
Archive | 2007
Jessica Boyle; Ashley Edward Fenwick; David Morris Gethin; Catherine Frances Mccusker