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Dive into the research topics where Atif Islam is active.

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Featured researches published by Atif Islam.


Carbohydrate Polymers | 2015

Fabrication of tethered carbon nanotubes in cellulose acetate/polyethylene glycol-400 composite membranes for reverse osmosis.

Aneela Sabir; Muhammad Shafiq; Atif Islam; Afsheen Sarwar; Muhammad Rizwan Dilshad; Amir Shafeeq; Muhammad Taqi Zahid Butt; Tahir Jamil

In this study pristine multi-walled carbon nanotubes (MWCNTs) were surface engineered (SE) in strong acidic medium by oxidation purification method to form SE-MWCNT. Five different amount of SE-MWCNT ranging from 0.1 to 0.5 wt% were thoroughly and uniformly dispersed in cellulose acetate/polyethylene glycol (CA/PEG400) polymer matrix during synthesis of membrane by dissolution casting method. The structural analysis, surface morphology and roughness was carried out by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and atomic force microscopy (AFM), respectively, which showed that the dispersed SE-MWCNT was substantially tethered in CA/PEG400 polymer matrix membrane. The thermogravimetric analysis (TGA) of membranes also suggested some improvement in thermal properties with the addition of SE-MWCNT. Finally, the performance of these membranes was assessed for suitability in drinking water treatment. The permeation flux and salt rejection were determined by using indigenously fabricated reverse osmosis pilot plant with 1000 ppm NaCl feed solution. The results showed that the tethered SE-MWCNT/CA/PEG400 polymer matrix membrane, with strong SE-MWCNTs/polymer matrix interaction, improved the salt rejection performance of the membrane with the salt rejection of 99.8% for the highest content of SE-MWCNT.


International Journal of Biological Macromolecules | 2015

Injectable biopolymer based hydrogels for drug delivery applications.

Sadia Atta; Shaista Khaliq; Atif Islam; Irtaza Javeria; Tahir Jamil; Muhammad Makshoof Athar; Muhammad Shafiq; Abdul Ghaffar

Biopolymer based pH-sensitive hydrogels were prepared using chitosan (CS) with polyethylene glycol (PEG) of different molecular weights in the presence of silane crosslinker. The incorporated components remain undissolved in different swelling media as they are connected by siloxane linkage which was confirmed by Fourier transform infrared spectroscopy. The swelling in water was enhanced by the addition of higher molecular weight PEG. The swelling behaviour of the hydrogels against pH showed high swelling in acidic and basic pH, whereas, low swelling was examined at pH 6 and 7. This characteristic pH responsive behaviour at neutral pH made them suitable for injectable controlled drug delivery. The controlled release analysis of Cefixime (CFX) (model drug) loaded CS/PEG hydrogel exhibited that the entire drug was released in 30 min in simulated gastric fluid (SGF) while in simulated intestinal fluid (SIF), 85% of drug was released in controlled manner within 80 min. This inferred that the developed hydrogels can be an attractive biomaterial for injectable drug delivery with physiological pH and other biomedical applications.


Carbohydrate Polymers | 2016

Novel green nano composites films fabricated by indigenously synthesized graphene oxide and chitosan.

Younus H. Khan; Atif Islam; Afsheen Sarwar; Shahzad Maqsood Khan; Muhammad Azeem Munawar; Saba Zia; Aneela Sabir; Muhammad Shafiq; Tahir Jamil

Graphene oxide (GO) was indigenously synthesized from graphite using standard Hummers method. Chitosan-graphene oxide green composite films were fabricated by mixing aqueous solution of chitosan and GO using dilute acetic acid as a solvent for chitosan. Chitosan of different viscosity and calculated molecular weight was used keeping amount of GO constant in each composite film. The structural properties, thermal stability and mechanical properties of the composite films were investigated using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and tensile test. FTIR studies revealed the successful synthesis of GO from graphite powder and it was confirmed that homogenous blending of chitosan and GO was promising due to oxygenated functional groups on the surface of GO. XRD indicated effective conversion of graphite to GO as its strong peak observed at 11.06° as compared to pristine graphite which appeared at 26°. Moreover, mechanical analysis confirmed the effect of molecular weight on the mechanical properties of chitosan-GO composites showing that higher molecular weight chitosan composite (GOCC-1000) showed best strength (higher than 3GPa) compared to other composite films. Thermal stability of GOCC-1000 was enhanced for which residual content increased up to 56% as compared to the thermal stability of GOCC-200 whose residue was restricted to only 24%. The morphological analysis of the composites sheets by SEM was smooth having dense structure and showed excellent interaction, miscibility, compatibility and dispersion of GO with chitosan. The prepared composite films find their applications as biomaterials in different biomedical fields.


Carbohydrate Polymers | 2016

Conjugation of silica nanoparticles with cellulose acetate/polyethylene glycol 300 membrane for reverse osmosis using MgSO4 solution.

Aneela Sabir; Muhammad Shafiq; Atif Islam; Faiza Jabeen; Amir Shafeeq; Adnan Ahmad; Muhammad Taqi Zahid Butt; Karl I. Jacob; Tahir Jamil

Thermally-induced phase separation (TIPS) method was used to synthesize polymer matrix (PM) membranes for reverse osmosis from cellulose acetate/polyethylene glycol (CA/PEG300) conjugated with silica nanoparticles (SNPs). Experimental data showed that the conjugation of SNPs changed the surface properties as dense and asymmetric composite structure. The results were explicitly determined by the permeability flux and salt rejection efficiency of the PM-SNPs membranes. The effect of SNPs conjugation on MgSO4 salt rejection was more significant in magnitude than on permeation flux i.e. 2.38 L/m(2)h. FTIR verified that SNPs were successfully conjugated on the surface of PM membrane. DSC of PM-SNPs shows an improved Tg from 76.2 to 101.8 °C for PM and PM-S4 respectively. Thermal stability of the PM-SNPs membranes was observed by TGA which was significantly enhanced with the conjugation of SNPs. The micrographs of SEM and AFM showed the morphological changes and increase in the valley and ridges on membrane surface. Experimental data showed that the PM-S4 (0.4 wt% SNPs) membrane has maximum salt rejection capacity and was selected as an optimal membrane.


International Journal of Biological Macromolecules | 2017

Development of a novel pH sensitive silane crosslinked injectable hydrogel for controlled release of neomycin sulfate

Sehrish Jabeen; Atif Islam; Abdul Ghaffar; Ayesha Hameed; Anbreen Bashir; Tahir Jamil; Tousif Hussain

Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the cationic (chitosan) and anionic (alginate) polymers with poly(vinyl alcohol). Tetraethoxysilane (TEOS) was used, as a crosslinker in different amounts due to its nonhazardous nature, to study its impact on physical and chemical properties of the prepared injectable hydrogels along with the controlled release of drug. The swelling response of the prepared hydrogels was examined in different solvent media which exhibited decreased swelling ratio with increase in the amount of TEOS. All the fabricated hydrogels represented highest swelling at acidic pH while low swelling at basic and neutral pH. This specific pH sensitive behavior at pH 7 made them an appropriate candidate for the injectable controlled drug delivery in which Neomycin Sulfate (NMS) was successfully loaded on suitable hydrogel (comprising 50μL TEOS) to study its release mechanism. The results revealed that in simulated gastric fluid (SGF), hydrogel released the entire drug (NMS) in initial 30min while in simulated intestinal fluid (SIF), NMS was released in a controlled way up to 83% in 80min. These results endorsed that the hydrogels could be practiced as a smart intelligent material for injectable controlled drug delivery as well as for other biomedical applications at physiological pH.


Materials Research-ibero-american Journal of Materials | 2015

An Investigation of Ac Impedance and Dielectric Spectroscopic Properties of Conducting Chitosan-silane Crosslinked-poly (Vinyl Alcohol) Blended Films

Atif Islam; Z. Imran; Tariq Yasin; Shahzad Maqsood Khan; Muhammad Shafiq; Aneela Sabir; Muhammad Azeem Munawar; Muhammad Hamid Raza; Tahir Jamil

The films of chitosan (CS)-silane crosslinked-poly(vinyl alcohol) (PVA) with different weight % were prepared. The effect on conductivity of CS/PVA blended films due to change in the concentration of PVA and temperature was investigated by impedance spectroscopy and showed good conductance properties. The complex impedance plots revealed single semicircular arcs indicating the bulk contribution to overall electrical behavior of all synthesized samples. The ac conductivity obeyed the Jonschers power law for all samples in the frequency range of 2 kHz to 2 MHz. The ionic conductivity of the films was increased with the increase in temperature for all synthesized samples which showed an increase in the number of effective charge carriers while it was decreased at a specific higher temperature for each film. The observed activation energy for CP4, CP8 and CP10 were 0.431, 0.610 and 0.425 eV, respectively. These properties showed that the films were promising materials to be employed for conducting properties.


International Journal of Biological Macromolecules | 2016

Fabrication and performance characteristics of tough hydrogel scaffolds based on biocompatible polymers.

Atif Islam; Tariq Yasin; Shahzad Maqsood Khan; Aneela Sabir; Muhammad Azeem Munawwar; Muhammad Shafiq; Tahir Jamil; Muhammad Hamid Raza

Novel silane crosslinked tough hydrogel scaffolds were prepared using chitosan (CS) and polyvinyl alcohol (PVA) to give network structure and scaffolds properties. The influence of crosslinking and PVA concentration on scaffolds were studied. Fourier transform infrared spectroscopy (FTIR) spectroscopy confirmed the presence of incorporated components. Tensile strength (TS) and fracture strain analysis of scaffolds were detected owing to the mutual effect of chemically and physically crosslinked network. Tough hydrogel scaffolds having 90% CS and 10% PVA exhibited TS of 49.18MPa and 10.15% elongation at break. The contact angle is less than 90° exhibited the hydrophilic nature of the scaffold. X-ray diffraction analysis (XRD) indicated the characteristics peaks fitting to CS and PVA and increase in the crystallinity of scaffolds. Cytotoxicity of scaffolds with different human fibroblast cell lines (F121, F192 and F84) for indirect method and human dermal fibroblast cell lines (F121) for direct method was evaluated. This indicated that these biomaterials were non-toxic, viable to the used cell lines, helpful in the growth of these cells and did not discharge toxic material damaging to the living cells.


Polymer-plastics Technology and Engineering | 2017

Synthesis, Characterization, and Application Studies of Polyurethane Acrylate Thermoset Coatings: Effect of Hard Segment

Misbah Sultan; Sadia Atta; Haq Nawaz Bhatti; Atif Islam; Tahir Jamil; Ismat Bibi

ABSTRACT The waterborne polyurethane acrylate coatings are smart option to reduce the environmental hazards. To evaluate the structure–property relationship, polyurethane acrylate coating dispersions were synthesized with aromatic and aliphatic hard segments. Furthermore, to evaluate the performance, dispersions were used to finish the cotton fabric. The dispersions were prepared by prepolymer method followed by emulsion polymerization in aqueous medium. The characterization of dispersions was performed by Fourier transform infrared, dynamic light scattering, atomic force microscopy, differential scanning calorimetry, and thermogravimetric analysis. In general, aliphatic hard segment has shown more appreciable results. But, thermal stability of aromatic polyurethane acrylate was more pronounced as inherent rigidity of aromatic diisocyanate dominates. GRAPHICAL ABSTRACT


Fibers and Polymers | 2015

In-situ crosslinked nanofiber mats of chitosan/poly(vinyl alcohol) blend: Fabrication, characterization and MTT assay with cancerous bone cells

Atif Islam; Tariq Yasin; M. A. Rafiq; Tahir Shah; Aneela Sabir; Shahzad Maqsood Khan; Tahir Jamil

Biocompatible crosslinked nanofiber mats of chitosan (CS)/poly(vinyl alcohol) (PVA) were fabricated using electrospinning technique. CS and PVA blends (7, 9 and 11 weight %) of prepared keeping ratios of CS: PVA to 1:4 and was crosslinked with tetraethoxysilane (TEOS). Fourier transform infrared (FTIR) analysis confirmed the existence of inter- and intramolecular hydrogen bonding between polymer chains and the development of siloxane linkage within the nanofibers. X-ray diffractometry (XRD) analysis showed an increase in the crystallinity of electrospun nanofibers after crosslinking as compared to the uncrosslinked nanofibers and with an increase in CS/PVA content. Scanning electron microscopy (SEM) micrographs exhibited the formation bead-free fibers at higher polymer concentration. The average size of the nanofibers was found in the range of 40 to 100 nm. The concentration and crosslinker content affected the mechanical and thermal properties of the nanofibers. The crosslinker has increased the tensile strength (TS) values upto 120 % and Young’s modulus by 71 % as compared to the uncrosslinked nanofibers while elongation at break was decreased in all nanofibers. The cell viability of the nanofibers was investigated by employing human cancerous bone cells (MG63). The obtained results showed that cancerous bone cells were not proliferated in the presence of nanofibers and the growth of the cells was inhibited confirming the worth of CS/PVA nanofibers against cancerous bone cells. This inherent behaviour can be exploited as base material for anticancer biomedical applications.


International Journal of Biological Macromolecules | 2018

γ-Irradiated chitosan based injectable hydrogels for controlled release of drug (Montelukast sodium)

Sadaf Hafeez; Atif Islam; Abbas Ali; Shahzad Maqsood Khan; Saba Zia; Kalsoom Anwar; Saba Urooge Khan; Tahir Jamil

Novel pH-sensitive γ-irradiated low molecular weight (MW) chitosan (CS) (pre-irradiated) and poly (vinyl alcohol) (PVA) blended injectable hydrogels, crosslinked with varying concentrations of glycerol, were fabricated for drug delivery application. The effect of low MW irradiated CS on controlled drug release was evaluated to address the problem of higher viscosity and lower solubility of high MW CS. The FTIR spectra of hydrogels depicted the presence of all the incorporated functional groups and the developed interactions (physical and chemical). The surface morphology of hydrogels assessed by scanning electron microscope exhibited porous microstructure. All hydrogels were subjected to the swelling analysis in different media (water, buffer and electrolytes). The pH sensitive hydrogel samples exhibited less swelling at acidic and neutral pH while higher swelling at basic pH. CPG-0.5 showed the highest swelling at all pH media as compared to other hydrogel samples. CPG-1.0 was selected for the release analysis of drug because of its highest swelling (114.47%) in distilled water having neutral pH. It was loaded with model drug (Montelukast Sodium) during the preparation phase and studied for drug release capability. The in-vitro controlled release evaluation of hydrogel (CPG-1.0) was performed in SGF and SIF using UV-visible spectroscopy. The results confirmed their applications in injectable drug release systems as all the loaded drug was released in 30 min in SGF (pH -1.2) while the release of drug in SIF (pH -6.8) was in controlled manner (99.62% in 3 h). The improved antibacterial activity of these hydrogel films was owing to the fact that the γ-irradiated low MW CS has ruptured the bacterial cell and its metabolism more efficiently by inflowing in the cell.

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Tahir Jamil

University of the Punjab

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Aneela Sabir

University of the Punjab

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Muhammad Shafiq

Pakistan Institute of Engineering and Applied Sciences

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Tariq Yasin

Pakistan Institute of Engineering and Applied Sciences

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Saba Zia

University of the Punjab

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Adnan Ahmad

University of the Punjab

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