Babak Riahi
Amgen
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Publication
Featured researches published by Babak Riahi.
Bioorganic & Medicinal Chemistry Letters | 2011
Jian Jeffrey Chen; Thomas Nguyen; Derin C. D’Amico; Wenyuan Qian; Jason Brooks Human; Toshihiro Aya; Kaustav Biswas; Christopher Fotsch; Nianhe Han; Qingyian Liu; Nobuko Nishimura; Tanya Peterkin; Kevin Yang; Jiawang Zhu; Babak Riahi; Randall W. Hungate; Neil G. Andersen; John T. Colyer; Margaret M. Faul; Augustus Kamassah; Judy Wang; Janan Jona; Gondi Kumar; Eileen Johnson; Benny C. Askew
The discovery of novel and highly potent oxopiperazine based B1 receptor antagonists is described. Compared to the previously described arylsulfonylated (R)-3-amino-3-phenylpropionic acid series, the current compounds showed improved in vitro potency and metabolic stability. Compound 17, 2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-2-piperazinyl)-N-((1R)-6-(1-piperidinylmethyl)-1,2,3,4-tetrahydro-1-naphthalenyl)acetamide, showed EC(50) of 10.3 nM in a rabbit biochemical challenge model. The practical syntheses of chiral arylsulfonylated oxopiperazine acetic acids are also described.
Archive | 2002
Vinod F. Patel; Benny C. Askew; Shon Booker; Guoqing Chen; Lucian V. Dipietro; Julie Germain; Gregory J. Habgood; Qi Huang; Tae-Seong Kim; Aiwen Li; Nobuko Nishimura; Rana Nomak; Babak Riahi; Chester Chenguang Yuan; Daniel Elbaum
Archive | 2003
Qi Huang; Guoqing Chen; Aiwen Li; Babak Riahi; Andrew Tasker; Kevin Yang; Chester Chenguang Yuan
Archive | 2003
Vinod F. Patel; Jr. Benny C. Askew; Shon Booker; Guoqing Chen; Lucian V. Dipietro; Julie Germain; Gregory J. Habgood; Qi Huang; Tae-Seong Kim; Aiwen Li; Nobuko Nishimura; Rana Nomak; Babak Riahi; Chester Chenguang Yuan; Daniel Elbaum
Archive | 2005
Jr Ben C. Askew; Toshihiro Aya; Kaustav Biswas; Guolin Cai; Jian J. Chen; Christopher Fotsch; Nianhe Han; Jason Brooks Human; Aiwen Li; Qingyian Liu; Tanya Peterkin; Wenyuan Qian; Babak Riahi; Chester Chenguang Yuan; Jiawang Zhu
Archive | 2003
Jr. Benny C. Askew; Jeffrey Adams; Shon Booker; Guoqing Chen; Lucian V. Dipietro; Daniel Elbaum; Julie Germain; Stephanie Geuns-Meyer; Gregory J. Habgood; Michael Handley; Qi Huang; Tae-Seong Kim; Aiwen Li; Nobuko Nishimura; Rana Nomak; Vinod F. Patel; Babak Riahi; Joseph L. Kim; Ning Xi; Kevin Yang; Chester Chenguang Yuan
Archive | 2004
Robert D. Groneberg; Ben Askew; Derin C. D'amico; James Zhan; Andras Toro; Hideo Suzuki; David A. Mareska; Nianh Han; Christopher Fotsch; Qinglan Liu; Babak Riahi; Kevin Yang; Aiwan Li; Chester Chenguang Yuan; Kaustav Biswas; Scott Harried; Tom Nguyen; Wenyuan Qian; Jian J. Chen; Rana Nomak
Archive | 2004
Robert D. Groneberg; James Zhan; Ben Askew; Derin C. D'amico; Nianhe Han; Christopher Fotsch; Qingyian Liu; Babak Riahi; Jiawang Zhu; Kevin Yang; Jian J. Chen; Rana Nomak
Bioorganic & Medicinal Chemistry Letters | 2006
Christopher Fotsch; Gloria Biddlecome; Kaustav Biswas; Jian Jeff Chen; Derin C. D’Amico; Robert Groneberg; Nianhe Bruce Han; Feng-Yin Hsieh; Augustus Kamassah; Gondi Kumar; Dianna Lester-Zeiner; Qingyian Liu; David A. Mareska; Babak Riahi; Yueh-Ju Judy Wang; Kevin Yang; James Zhan; Joe Zhu; Eileen Johnson; Gordon Ng; Benny C. Askew
Archive | 2004
Robert D. Groneberg; James Zhan; Benny C. Askew; Derin C. D'amico; Nianhe Han; Christopher Fotsch; Qingyian Liu; Babak Riahi; Jiawang Zhu; Kevin Yang; Jian Jeffrey Chen; Rana Nomak
