Bengü Tuman

Bilateral nevus comedonicus of the eyelids associated with bladder cancer and successful treatment with topical tretinoin.

Mualla Polat*, Bengu Altunay Tuman*, Asli Sahin†, Umit Dogan‡ & Cetin Boran§ *Department of Dermatology, Faculty of Medicine, Abant IzzetBaysal University, Bolu, Turkey, †Department of Dermatology, IzzetBaysal Education and Research Hospital, Bolu, Turkey, ‡Department of Ophthalmology, Faculty of Medicine, Abant IzzetBaysal University, Bolu, Turkey and §Department of Pathology, Faculty of Medicine, Abant IzzetBaysal University, Bolu, Turkey

A rare side effect of escitalopram: bilateral peripheral edema

Escitalopram, S-isomer of sitalopram is well tolerated, rapid onset efficacy and used in the tratment of depression and other psychiatric disorders in elderly1-3. Escitalopram is highly serotonin specific and has minimal effect on the reuptake of other neurotransmitters4. Insomnia, headache, tremor, nausea, flushing, sweating, diarrhea, sexual dysfunction have been reported to be adverse drug reaction during escitalopram therapy3,5,6. In elderly patients, edema is an important health problem. Heart failure, renal failure, malabsorpsion, liver failure, allergic reactions, local inflammation and infections, burns, lymphatic obstruction increased capillary permeability, venous obstruction and drugs can cause peripheral edema7. Antihypertensive medications, nonsteroidal anti-inflammatory agents, calcium channel blockers, corticosteroids, hormones, antibiotics, beta blockers and direct vasodilators are drugs that often cause peripheral edema7,8. Edema has been reported rarely with psychiatric medications. Premarketing trials have reported peripheral edema as an infrequent adverse event which occured less than 1/1009. To the best of our knowladge, there are two case reports that edema associated with escitalopram. First, bilateral ankle edema in 69 year-old female patient after one month therapy with escitalopram 30 mg per day, resolved within first week after discontinuation of the drug10. In second case, bilateral pedal edema associated with escitalopram 10 mg per day developed 9th day of the treatment and resolved within 10 days after discontinuation of the drug11. Here, we report a case of bilateral leg edema on the 7th day of the treatment with escitalopram 10 mg/day and resolved within 12 days after discontinuation of the drug.

A case of unilateral blaschkoid lichen planus pigmentosus

©2017 by Anais Brasileiros de Dermatologia Dear Editor, Lichen planus pigmentosus (LPP) is a rare variant of lichen planus.1 A few cases of LPP involving linear, blaschkoid, and zosteriform patterns have been reported in the literature.2-4 We herein describe a case involving a 48-year-old female patient with unilateral abdominal involvement of LPP following the lines of Blaschko. A 48-year-old female patient was admitted to our clinic with a 2-year history of a pruritic rash localized to the right half of the abdomen. The patient’s medical history revealed that she had been using levetiracetam and levothyroxine for 8 years to treat epilepsy REFERENCES 1. Soares PBN, Marangon LD, Leal RM, Capistrano HM, Marigo HA. Neurilemoma: relato de caso clínico. Rer Odontol Bras Central 2012;21:458-61. 2. Martinez D, Cotrim C, Cury Chicralla P, Lupi O. Schwannoma: An unexpected presentation. Dermatol Surg. 2016;42:1112-3. 3. Nascimento G, Nomi T, Marques R, Leiria J, Silva C, Periquito J. Ancient schwannoma of superficial peroneal nerve presenting as intermittent leg pain: A case report. Int J Surg Case Rep. 2015;6C:19-22. 4. Mendeszoon MJ, Cunningham N, Crockett RS, Kushner D. Schwannoma: a case report. Foot Ankle Online J. 2009;2:4. 5. Kondo RN, Pontello Junior R, Belinetti FM, Cilião C, Vasconcellos VR, Grimaldi DM. Proliferating pilomatricoma – Case report. An Bras Dermatol. 2015;90:94-6.