Benjamin L. Wright
Mayo Clinic
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Publication
Featured researches published by Benjamin L. Wright.
The Journal of Allergy and Clinical Immunology | 2017
Brian P. Vickery; Jelena P. Berglund; Caitlin M. Burk; Jason P. Fine; Edwin H. Kim; Jung In Kim; Corinne A. Keet; Michael D. Kulis; Kelly G. Orgel; Rishu Guo; Pamela H. Steele; Yamini Virkud; Ping Ye; Benjamin L. Wright; Robert A. Wood; A. Wesley Burks
Background: Oral immunotherapy (OIT) is an effective experimental food allergy treatment that is limited by treatment withdrawal and the frequent reversibility of desensitization if interrupted. Newly diagnosed preschool children may have clinical and immunological characteristics more amenable to treatment. Objective: We sought to test the safety, effectiveness, and feasibility of early OIT (E‐OIT) in the treatment of peanut allergy. Methods: We enrolled 40 children aged 9 to 36 months with suspected or known peanut allergy. Qualifying subjects reacted to peanut during an entry food challenge and were block‐randomized 1:1 to receive E‐OIT at goal maintenance doses of 300 or 3000 mg/d in a double‐blinded fashion. The primary end point, sustained unresponsiveness at 4 weeks after stopping early intervention oral immunotherapy (4‐SU), was assessed by double‐blinded, placebo‐controlled food challenge either upon achieving 4 prespecified criteria, or after 3 maintenance years. Peanut‐specific immune responses were serially analyzed. Outcomes were compared with 154 matched standard‐care controls. Results: Of 40 consented subjects, 3 (7.5%) did not qualify. Overall, 29 of 37 (78%) in the intent‐to‐treat analysis achieved 4‐SU (300‐mg arm, 17 of 20 [85%]; 3000 mg, 12 of 17 [71%], P = .43) over a median of 29 months. Per‐protocol, the overall proportion achieving 4‐SU was 29 of 32 (91%). Peanut‐specific IgE levels significantly declined in E‐OIT‐treated children, who were 19 times more likely to successfully consume dietary peanut than matched standard‐care controls, in whom peanut‐specific IgE levels significantly increased (relative risk, 19.42; 95% CI, 8.7‐43.7; P < .001). Allergic side effects during E‐OIT were common but all were mild to moderate. Conclusions: At both doses tested, E‐OIT had an acceptable safety profile and was highly successful in rapidly suppressing allergic immune responses and achieving safe dietary reintroduction.
Pediatric Clinics of North America | 2015
Bruce J. Lanser; Benjamin L. Wright; Kelly Orgel; Brian P. Vickery; David M. Fleischer
Food allergy is increasing in prevalence; as a result, there is intense focus on developing safe and effective therapies. Current methods of specific immunotherapy include oral, sublingual, and epicutaneous, while nonspecific methods that have been investigated include: Chinese herbal medicine, probiotics, and anti-IgE antibodies. Although some studies have demonstrated efficacy in inducing desensitization, questions regarding safety and the potential for achieving immune tolerance remain. Although some of these therapies demonstrate promise, further investigation is required before their incorporation into routine clinical practice.
Journal of the Pediatric Infectious Diseases Society | 2018
Nicholas Bennett; Paul J. Maglione; Benjamin L. Wright; Christa S. Zerbe
The Journal of Allergy and Clinical Immunology: In Practice | 2017
Shauna Schroeder; Sergei I. Ochkur; Kelly P. Shim; Katie M. Galvin; Cindy S. Bauer; James J. Lee; Benjamin L. Wright
The Journal of Allergy and Clinical Immunology: In Practice | 2018
Benjamin L. Wright; Matthew A. Rank
The Journal of Allergy and Clinical Immunology | 2018
Benjamin L. Wright; Matthew A. Rank; Kelly S. Shim; Alfred D. Doyle; Elizabeth A. Jacobsen; Monali Manohar; Bryan J. Bunning; R. Sharon Chinthrajah; Wenming Zhang; Kari C. Nadeau
The Journal of Allergy and Clinical Immunology | 2018
Brittany T. Hines; Matthew A. Rank; Benjamin L. Wright; Lisa Marks; Matthew Greenhawt; Evan S. Dellon
The Journal of Allergy and Clinical Immunology | 2018
Benjamin L. Wright; Nathalie Nguyen; Kelly P. Shim; Joanne C. Masterson; Elizabeth A. Jacobsen; Sergei I. Ochkur; James J. Lee; Glenn T. Furuta
The AAAAI/WAO Joint Congress | 2018
Benjamin L. Wright
The Journal of Allergy and Clinical Immunology | 2017
Tyler R. Yates; Benjamin L. Wright; Cindy S. Bauer