Bertel Hansen

Quinoline alkaloids from Acronychia laurifolia.

Bioassay-directed fractionation of a root extract of Acronychia laurifolia (Rutaceae) using the KB-V1+ human tumor cell line led to the isolation of six quinoline alkaloids. One of these alkaloids is novel, namely, 2,3-methylenedioxy-4,7-dimethoxyquinoline and the other five were identified as the known compounds, evolitrine, gamma-fagarine, skimmianine, kokusaginine and maculosidine. Two known bis-tetrahydrofuran lignans, sesamolin and yangambin, were also identified. The structure of the new alkaloid was determined by spectroscopic methods. All of the isolates were evaluated against a panel of human cancer cell lines; four of the alkaloids showed weak cytotoxic activity.

Order in chaos: Ballot order effects in a post-conflict election?

Ballot order effects are well documented in established democracies, but less so in newly democratizing countries. In this research note we analyze ballot order effects in the 2010 parliamentary election in Afghanistan. The election provides a first look at ballot order effects in a high stakes, post-conflict election. In this setting, we argue that limited cognitive skills and information are more likely explanations of potential ballot order effects than mechanisms of lacking effort or ambivalence of choice. However, we find no clear evidence of a positive effect on the vote share of a higher ballot position. This raises the broader question of how applicable anomalies found in political behavior are to post-conflict democracies.