Buchammagari Haritha

An efficient approach towards the stereospecific synthesis of epoxides from phospholene oxides

A novel method has been developed for stereospecific conversion of 2-phospholene 1-oxides into their corresponding 2,3-epoxides in high yields using sodium peroxide as a reagent.

An efficient synthesis of novel deoxy phospha sugar pyrimidine nucleosides

Abstract An efficient method is described in the synthesis of several novel deoxy phospha sugar pyrimidine nucleosides in racemic form, analogs of normal sugar nucleosides, in high yields by treatment of (±)-2-aminophospholane 1-oxide with several, α-cyano-, -acetyl-, -ethoxycarbonyl-β-ethoxy-N-ethoxycarbonylacrylamides.

Preparation And Characterization Of Phospholanes And Phospha Sugars As Novel Anti-Cancer Agents

Diastereo isomeric erythro and threo forms of 2,3-epoxy-l-phenylphospholane 1-oxides were synthesized from threo and erythro forms of 2-bromo-3-hydroxy-l-phenylphospholane 1-oxides being prepared from l-phenyl-2-phospholene 1-oxide. Alternatively, the epoxides were also prepared by the epoxidation of the 2-phospholene with peroxides such as sodium peroxide and hydrogen peroxide. The reactivity and regioselectivity for the reaction of erythro and threo forms of the 2,3-epoxides with nucleophiles were investigated by using amines, and the reaction afforded 2-amino-3-hydroxy-l-phenylphospholane 1-oxides, which correspond to phospha sugar N-glycosides. 2,3-Dibromo-3-methyl-l-phenylphospholane 1-oxides were first prepared from 3-methyl-l-phenyl-2-phospholene 1-oxide. The prepared phospholanes or phospha sugars were biologically qualified by ΜΤΓ (3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide) in vitro method to find that some of these phosphorus heterocycles or phospha sugars have quite efficient anti-cancer activity for leukemia cells in manners of (i) wide spectra, (ii) high activities, and (iii) high specificities.

Diastereoselective Preparation of a New Class of Deoxy λ5 Phospha Sugar Derivatives

Abstract Several new classes of deoxy phospha sugar derivatives, analogs of normal sugar derivatives, were conveniently synthesized using 1‐methoxy‐2‐phospholene 1‐oxide as a starting material. All compounds were structurally characterized by their spectral data, and stereochemistry was determined by spectral and X‐ray crystallographic analyses.