C. González San Segundo

Metástasis mamarias de rabdomiosarcoma embrionario: a propósito de dos casos y revisión de la literatura

La presencia de metastasis mamarias es un hecho poco frecuente en Oncologia. En los ninos y adultos jovenes el tumor primario mas frecuente es el rabdomiosarcoma, siendo los rabdomiosarcomas primarios de mama excepcionales. Se describen dos casos de rabdomiosarcoma metastasico en mama en dos adolescentes con varias caracteristicas atipicas en su presentacion: la variedad embrionaria y la localizacion primaria en seno maxilar. Se analizan los casos descritos en la literatura hasta la actualidad, estudiando los datos epidemiologicos, clinicos, diagnosticos y terapeuticos de esta rara entidad.

Consensus statement on definition, diagnosis, and management of high-risk prostate cancer patients on behalf of the Spanish Groups of Uro-Oncology Societies URONCOR, GUO, and SOGUG

PurposeProstate cancer (PCa) is the most prevalent malignancy in men and the second cause of mortality in industrialized countries.MethodsBased on Spanish Register of PCa, the incidence of high-risk PCa is 29%, approximately. In spite of the evidence-based beneficial effect of radiotherapy and androgen deprivation therapy in high-risk PCa, these patients (pts) are still a therapeutic challenge for all specialists involved, in part due to the absence of comparative studies to establish which of the present disposable treatments offer better results.ResultsNowadays, high-risk PCa definition is not well consensual through the published oncology guides. Clinical stage, tumour grade, and number of risk factors are relevant to be considered on PCa prognosis. However, these factors are susceptible to change depending on when surgical or radiation therapy is considered to be the treatment of choice. Other factors, such as reference pathologist, different diagnosis biopsy schedules, surgical or radiotherapy techniques, adjuvant treatments, biochemical failures, and follow-up, make it difficult to compare the results between different therapeutic options.ConclusionsThis article reviews important issues concerning high-risk PCa. URONCOR, GUO, and SOGUG on behalf of the Spanish Groups of Uro-Oncology Societies have reached a consensus addressing a practical recommendation on definition, diagnosis, and management of high-risk PCa.

Radioterapia esplénica: a próposito de 8 casos. Indicaciones y revisión de la literatura

Clinical indications of splenic irradiation in haematological disorders include the irradiation in lymphoproliferative disorders with spleen infiltration, palliative treatment of splenomegaly in malignant diseases like chronic lymphocytic leukaemia or myeloproliferative disorders, with the purpose of relief from abdominal pain associated with capsular enlargement size and decrease cytopenias secundaries to hypersplenism. This paper reports our experience with spleen irradiation in the Hospital General Universitario Gregorio Maranon in the last five years, and analizes indications, results and toxicity, and an actual review of the literature.