Carl A. Gemzell

Further studies of the clinical effects of human pituitary follicle-stimulating hormone (FSH). Lack of response in ovarian insufficiency.

Follicle-stimulating hormone prepared from human pituitaries (human pituitary FSH) has been shown to produce polycystic ovaries, endometrial changes and a great increase in the urinary excretion of estrogens in young amenorrhceic women (Gemze l l , D i c z f a l u s y , and T i l l i n g e r , 1958). A typical case is presented in Fig. I. Continued studies on 30 such patients (to be reported in a forthcoming communication) revealed that the great majority of them reacted in the same way. However, the hormone failed to produce any effect in a group of 7 patients. These women have heen submitted to a detailed investigation, the results of which are reported in this paper.

Diffuse Stromal Luteinization of the Ovaries Associated with Masculinization Syndrome and Endometrial Hyperplasia: Report of a Case

The present report describes a wonian with amenorrhea, adi posity, virilism, endometrial hyperplasia, and diffuse luteinization of the ovaries. The special interest of the case lies in the fact that the ovaries were completely removed and examined histologically, that the urinary excretion of gonadotrophin, estrogens, I 7-ketosteroids and pregnandiol and the plasma levels of 17-hydroxycorticosteroids were estimated before as well as after operation.

Plasma levels of 17-hydroxycorticosteroids and urinary excretion of 17-ketosteroids in normal children.

The plasma levels of 17‐hydroxycorticosteroids were studied in 34 children without evident disease. The results obtained are in good agreement with those previously reported by others.

Plasma levels of 17-hydroxycorticosteroids in erythroblastosis fetalis.

After a normal labour the plasma levels of 17‐hydroxycorticosteroids of 64 Rh‐isoimmunized mothers who are all multiparae are significantly higher than the plasma levels of normal multiparae. It is suggested that the Rh‐isoimmunized mothers due to the disease of their expected infants are under a more pronounced psychological strain than the normal multiparae.

Das Wachstumshormon im retroplacentären Blut und im Nabelschnurblut

Bei dem stets zunehmenden Interesse an der Rolle, die das hypophysare Wachstumshormon oder der somatotrope Faktor in der humanen Physiologie und neuerdings auch in der humanen Pathologie spielt, ist es von groster Wichtigkeit, das eine zuverlassige Bestimmungsmethode fur den Nachweis des Hormons in Plasmaproben von klinisch tragbarer Grosenordnung entwickelt wird.