Carl M. Maresh

The Induction and Decay of Heat Acclimatisation in Trained Athletes

SummaryHeat acclimatisation/acclimation involves a complex of adaptations which includes decreased heart rate, rectal temperature, perceived exertion as well as increased plasma volume and sweat rate. These adaptations serve to reduce physiological strain, improve an athlete’s ability to exercise in a hot environment, and reduce the incidence of some forms of heat illness. Few differences exist in the ability of men and women to acclimatise to heat. Typically, older runners do not perform in the heat as well as younger runners, but physical training can negate differences between these groups. Hormonal adaptations (e.g. aldosterone, vasopressin) during heat acclimatisation encourage fluid-electrolyte retention and cardiovascular stability. Athletes with high maximal aerobic power (V̇O2max) acclimatise to heat faster (and lose adaptations slower when they are inactive in a cool environment) than athletes with low V̇O2max values. Physical training in a cool environment improves physiological responses to exercise at high ambient temperatures. In attempting to optimise heat acclimatisation, athletes should maintain fluid-electrolyte balance, exercise at intensities greater than 50% V̇O2max for 10 to 14 days, and avoid factors (e.g. sleep loss, infectious disease) which are known to reduce heat tolerance. Once acclimatisation has been achieved, inactivity results in a decay of favourable adaptations, after only a few days or weeks.

Testosterone physiology in resistance exercise and training: the up-stream regulatory elements.

Testosterone is one of the most potent naturally secreted androgenicanabolic hormones, and its biological effects include promotion of muscle growth. In muscle, testosterone stimulates protein synthesis (anabolic effect) and inhibits protein degradation (anti-catabolic effect); combined, these effects account for the promotion of muscle hypertrophy by testosterone. These physiological signals from testosterone are modulated through the interaction of testosterone with the intracellular androgen receptor (AR). Testosterone is important for the desired adaptations to resistance exercise and training; in fact, testosterone is considered the major promoter of muscle growth and subsequent increase in muscle strength in response to resistance training in men. The acute endocrine response to a bout of heavy resistance exercise generally includes increased secretion of various catabolic (breakdown- related) and anabolic (growth-related) hormones including testosterone. The response of testosterone and AR to resistance exercise is largely determined by upper regulatory elements including the acute exercise programme variable domains, sex and age. In general, testosterone concentration is elevated directly following heavy resistance exercise in men. Findings on the testosterone response in women are equivocal with both increases and no changes observed in response to a bout of heavy resistance exercise. Age also significantly affects circulating testosterone concentrations. Until puberty, children do not experience an acute increase in testosterone from a bout of resistance exercise; after puberty some acute increases in testosterone from resistance exercise can be found in boys but not in girls. Aging beyond 35–40 years is associated with a 1–3% decline per year in circulating testosterone concentration in men; this decline eventually results in the condition known as andropause. Similarly, aging results in a reduced acute testosterone response to resistance exercise in men. In women, circulating testosterone concentration also gradually declines until menopause, after which a drastic reduction is found. In summary, testosterone is an important modulator of muscle mass in both men and women and acute increases in testosterone can be induced by resistance exercise. In general, the variables within the acute programme variable domains must be selected such that the resistance exercise session contains high volume and metabolic demand in order to induce an acute testosterone response.

Cold water immersion: the gold standard for exertional heatstroke treatment.

The key to maximize the chances of surviving exertional heatstroke is rapidly decreasing the elevated core body temperature. Many methods exist to cool the body, but current evidence strongly supports the use of cold water. Preferably, the athlete should be immersed in cold water. If lack of equipment or staff prevents immersion, a continual dousing with cold water provides an effective cooling modality. We refute the many criticisms of this treatment and provide scientific evidence supporting cold water immersion for exertional heatstroke.

IMPACT OF VICOPROFEN ON PLASMA PROENKEPHALIN PEPTIDE F CONCENTRATIONS AFTER

Peptide F [preproenkephalin (107–140)] has been shown to have stress-induced opiate-like activities with both analgesic and immune modulation characteristics.PURPOSE:The purpose of this study was to determine the effects of Vicopofen (hydrocodone bitartrate 7.5 mg with ibuprofen 200mg), ibuprofen (2

Relationship between the number of repetitions and selected percentages of one repetition maximum in free weight exercises in trained and untrained men.

Resistance exercise intensity is commonly prescribed as a percent of 1 repetition maximum (1RM). However, the relationship between percent 1RM and the number of repetitions allowed remains poorly studied, especially using free weight exercises. The purpose of this study was to determine the maximal number of repetitions that trained (T) and untrained (UT) men can perform during free weight exercises at various percentages of 1RM. Eight T and 8 UT men were tested for 1RM strength. Then, subjects performed 1 set to failure at 60, 80, and 90% of 1RM in the back squat, bench press, and arm curl in a randomized, balanced design. There was a significant (p < 0.05) intensity × exercise interaction. More repetitions were performed during the back squat than the bench press or arm curl at 60% 1RM for T and UT. At 80 and 90% 1RM, there were significant differences between the back squat and other exercises; however, differences were much less pronounced. No differences in number of repetitions performed at a given exercise intensity were noted between T and UT (except during bench press at 90% 1RM). In conclusion, the number of repetitions performed at a given percent of 1RM is influenced by the amount of muscle mass used during the exercise, as more repetitions can be performed during the back squat than either the bench press or arm curl. Training status of the individual has a minimal impact on the number of repetitions performed at relative exercise intensity.

Effect of Caffeine on Sport-specific Endurance Performance: A Systematic Review

Ganio, MS, Klau, JF, Casa, DJ, Armstrong, LE, and Maresh, CM. Effect of caffeine on sport-specific endurance performance: a systematic review. J Strength Cond Res 23(1): 315-324, 2009-Endurance athletes often ingest caffeine because of its reported ergogenic properties. Although there are a vast number of studies quantifying caffeines effects, many research studies measure endurance performance using a time-to-exhaustion test (subjects exercise at a fixed intensity to volitional exhaustion). Time-to-exhaustion as a performance measure is not ideal because of the high degree of measurement variability between and within subjects. Also, we are unaware of any endurance sports in which individuals win by going a longer distance or for a longer amount of time than their competitors. Measuring performance with a time-trial test (set distance or time with best effort) has high reproducibility and is more applicable to sport. Therefore, the purpose of this review was to critically and objectively evaluate studies that have examined the effect of caffeine on time-trial endurance (>5 minutes) performance. A literature search revealed 21 studies with a total of 33 identifiable caffeine treatments that measured endurance performance with a time-trial component. Each study was objectively analyzed with the Physiotherapy Evidence Database (PEDro) scale. The mean PEDro rating was 9.3 out of 10, indicating a high quality of research in this topic area. The mean improvement in performance with caffeine ingestion was 3.2 ± 4.3%; however, this improvement was highly variable between studies (−0.3 to 17.3%). The high degree of variability may be dependent on a number of factors including ingestion timing, ingestion mode/vehicle, and subject habituation. Further research should seek to identify individual factors that mediate the large range of improvements observed with caffeine ingestion. In conclusion, caffeine ingestion can be an effective ergogenic aid for endurance athletes when taken before and/or during exercise in moderate quantities (3-6 mg·kg−1 body mass). Abstaining from caffeine at least 7 days before use will give the greatest chance of optimizing the ergogenic effect.

Hydration and Muscular Performance Does Fluid Balance Affect Strength, Power and High-Intensity Endurance?

Significant scientific evidence documents the deleterious effects of hypohydration (reduced total body water) on endurance exercise performance; however, the influence of hypohydration on muscular strength, power and high-intensity endurance (maximal activities lasting >30 seconds but <2 minutes) is poorly understood due to the inconsistent results produced by previous investigations. Several subtle methodological choices that exacerbate or attenuate the apparent effects of hypohydration explain much of this variability. After accounting for these factors, hypohydration appears to consistently attenuate strength (by ≈2%), power (by ≈3%) and high-intensity endurance (by ∼10%), suggesting alterations in total body water affect some aspect of force generation. Unfortunately, the relationships between performance decrement and crucial variables such as mode, degree and rate of water loss remain unclear due to a lack of suitably uninfluenced data. The physiological demands of strength, power and high-intensity endurance couple with a lack of scientific support to argue against previous hypotheses that suggest alterations in cardiovascular, metabolic and/or buffering function represent the performance-reducing mechanism of hypohydration. On the other hand, hypohydration might directly affect some component of the neuromuscular system, but this possibility awaits thorough evaluation. A critical review of the available literature suggests hypohydration limits strength, power and highintensity endurance and, therefore, is an important factor to consider when attempting to maximise muscular performance in athletic, military and industrial settings.

Exercise intensity alters postexercise hypotension.

Objective Blood pressure (BP) is immediately lowered after a session of dynamic exercise, e.g. postexercise hypotension (PEH). The optimal exercise intensity needed to evoke PEH has not been established. We examined the effect of light (LITE) and moderate (MOD) exercise intensity on PEH. Design Subjects were 49 men (mean ± SEM, 43.8 ± 1.4 years) with high normal to stage 1 hypertension (145.0 ± 1.5/85.8 ± 1.1 mmHg). Men randomly completed three blinded experiments: a control session and two cycle exercise bouts, one at 40% (LITE) and the other at 60% (MOD) of maximal oxygen consumption. Methods Experiments began with a baseline period and were conducted at the same time of day and separated by ⩾ 2 days. Subjects wore an ambulatory BP monitor after the experiments. Repeated measure analysis of variance (ANOVA) tested if BP and heart rate differed over time and between experimental conditions. Multivariate regression tested factors related to the BP response. Results For 9 h after all experiments, average awake systolic blood pressure (SBP) increased and diastolic blood pressure (DBP) decreased compared with baseline (P < 0.001). Average awake SBP increased up to 6.9 mmHg less (P < 0.001) and DBP decreased 2.6 mmHg more (P < 0.05) after exercise versus control. For 5 h, PEH was greater after MOD; but over the course of 9 h, LITE was as effective as MOD in eliciting PEH. Baseline BP was the primary factor explaining the BP response (β = −0.434 to −0.718, r2 = 0.096–0.295). Conclusions LITE and MOD evoked PEH throughout the daytime hours. Lower intensity dynamic exercise such as walking, contributes to BP control in men with hypertension.

Resistance Exercise Biology Manipulation of Resistance Exercise Programme Variables Determines the Responses of Cellular and Molecular Signalling Pathways

Recent advances in molecular biology have elucidated some of the mechanisms that regulate skeletal muscle growth. Logically, muscle physiologists have applied these innovations to the study of resistance exercise (RE), as RE represents the most potent natural stimulus for growth in adult skeletal muscle. However, as this molecular-based line of research progresses to investigations in humans, scientists must appreciate the fundamental principles of RE to effectively design such experiments. Therefore, we present herein an updated paradigm of RE biology that integrates fundamental RE principles with the current knowledge of muscle cellular and molecular signalling. RE invokes a sequential cascade consisting of: (i) muscle activation; (ii) signalling events arising from mechanical deformation of muscle fibres, hormones, and immune/inflammatory responses; (iii) protein synthesis due to increased transcription and translation; and (iv) muscle fibre hypertrophy. In this paradigm, RE is considered an ‘upstream’ signal that determines specific downstream events. Therefore, manipulation of the acute RE programme variables (i.e. exercise choice, load, volume, rest period lengths, and exercise order) alters the unique ‘fingerprint’ of the RE stimulus and subsequently modifies the downstream cellular and molecular responses.

Whole-body cooling of hyperthermic runners: Comparison of two field therapies☆

Severe exercise-induced hyperthermia requires rapid cooling. Of the many cooling modalities available, there is disagreement over which is the most effective. The purpose of this field study was to compare two cooling therapies for hyperthermic distance runners who had completed an 11.5-km summer foot race. Twenty-one distance runners (mean [+/- SE] initial rectal temperature 41.2 +/- 0.2 degrees C) were treated either by ice water immersion (1 to 3 degrees C, n = 14) or by air exposure while wrapped in wet towels (24.4 degrees C ambient, n = 7). Ice water immersion versus air exposure resulted in significantly different (P < .005) pretherapy to posttherapy changes in rectal temperature (-3.0 +/- 0.3 v -1.4 +/- 0.3 degrees C) and mean cooling rate (0.20 +/- 0.02 v 0.11 +/- 0.02 degrees C/min). Ice water immersion cooled approximately twice as fast as air exposure. These data refute the theory that ice water immersion is an inefficient cooling modality.