Chang-Ho Jeong
Gyeongsang National University
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Publication
Featured researches published by Chang-Ho Jeong.
Journal of Agricultural and Food Chemistry | 2011
Sun-Jin Hur; Soo-Jeong Park; Chang-Ho Jeong
This study was conducted to investigate the effects of buckwheat ( Fagopyrum esculentum Moench cv. Yangjul No. 2) extract on the antioxidant activity of lipids in mouse brain and the structural change during in vitro human digestion. Buckwheat was collected from a wild farm and extracted with water. The buckwheat extracts were then passed through an in vitro human digestion model that simulated the composition of the mouth, stomach, and small intestine juice. The results confirmed that the main phenolics of buckwheat extract were rutin, quercitrin, and quercetin. The rutin content increased with digestion of the buckwheat (from 48.82 to 96.34 μg/g) and rutin standard samples (from 92.76 to 556.56 μg/g). Antioxidant activity was more strongly influenced by in vitro human digestion of both buckwheat and rutin standard. After digestion by the small intestine, the antioxidant activity values were dramatically increased (from 5.06 to 87.82%), whereas the antioxidant activity was not influenced by digestion in the stomach for both buckwheat extract and rutin standard. Inhibition of lipid oxidation of buckwheat in mouse brain lipids increased after digestion in the stomach for both buckwheat extract and the rutin standard. The major finding of this study was that in vitro human digestion may be an important modulator of the antioxidant capacity of buckwheat and that this may be because in vitro human digestion increased the antioxidative activity via an increase in antioxidants such as rutin and quercetin.
Journal of Medicinal Food | 2009
Soo Jung Choi; Chang-Ho Jeong; Sung-Gil Choi; Jiyeon Chun; Young-Jun Kim; Jeongmin Lee; Dong-Hoon Shin; Ho Jin Heo
The antioxidative and protective effects of zeatin against amyloid beta-protein (Abeta)-induced neurotoxicity were investigated using PC12 cells. Zeatin showed antioxidative and cell protective effects against Abeta-induced neurotoxicity. In this study, we also evaluated the effect of zeatin on learning and memory capacity in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg of body weight). Zeatin, when administered to mice at 4.5 mg/kg of body weight, significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and Y-maze test. Injecting mice with scopolamine impaired performance on the passive avoidance test (48 +/- 4.5% decrease) and on the Y-maze test (12 +/- 1.3% decrease). In contrast, mice treated with zeatin before scopolamine injections were protected from these changes (5-34% decrease in step-through latency; 1-4% decrease in alternation behavior). The present results suggest a possible chemopreventive role of zeatin in Alzheimers disease.
Food Science and Biotechnology | 2012
Ji Hye Kim; Gwi Nam Choi; Ji Hyun Kwak; Chang-Ho Jeong; Hee Rok Jeong; Uk Lee; Man-Jo Kim; Ho Jin Heo
Antioxidant capacities (ABTS radical scavenging assay and ferric reducing/antioxidant power assay), mushroom tyrosinase inhibitory effect, and α-melanocyte stimulating hormone (α-MSH) induced melanogenesis inhibitory effect of 60% methanol extracts and ethylacetate fractions from chestnut inner skin in B16F10 cells were investigated to inspect whitening effect. Above research showed that 60% methanol extracts and ethylacetate fractions from chestnut inner skin resulted in a dose-dependent manner on in vitro antioxidant effects. Especially, the ethylacetate fractions inhibited enzyme activity of mushroom tyrosinases with an IC50 value of 160 μg/mL. Ethylacetate fractions from chestnut inner skin also decreased cellular melanin synthesis in B16F10 melanoma cells. Expression of tyrosinase showed that ethylacetate fractions from chestnut inner skin significantly decreased cellular melanogenesis. Consequently, these results suggest that chestnut inner skin extracts can be considered for a whitening agent of human skin.
Journal of The Korean Society of Food Science and Nutrition | 2004
Young-Nam Lee; Chang-Ho Jeong; Ki-Hwan Shim
This study was performed to examine in vitro antioxidative activities such as DPPH radical scavenging activity, reducing power and tyrosinase inhibitory effect of various solvent fractions from Chionanthus retusa leaves. Ethyl acetate fraction showed potent antioxidative activity and tyrosinase inhibitory effect. The active compound was isolated from the butanol fraction by silica gel column chromatography and MPLC. The isolated compound was luteolin-4`-O-glucoside determined by , -NMR and 2D NMR. Compared with several antioxidant compounds, luteolin-4`-O-glucoside exhibited effective DPPH radical scavenging activity and reducing power in a concentration dependent manner. Bioassay with pure luteolin-4`-O-glucoside showed a dose-independent inhibitory effect on L-DOPA oxidation by mushroom tyrosinase and its values were established as 23.2 . Therefore, we may suggest that luteolin-4`-O-glucoside can be used as a food additive possessing the potent antioxidative activity and skin-whitening cosmetic material.
Food Chemistry | 2010
Chang-Ho Jeong; Gwi Nam Choi; Ji Hye Kim; Ji Hyun Kwak; Dae-Ok Kim; Young Jun Kim; Ho Jin Heo
Food Chemistry | 2012
Gwi Nam Choi; Ji Hye Kim; Ji Hyun Kwak; Chang-Ho Jeong; Hee Rok Jeong; Uk Lee; Ho Jin Heo
Korean Journal of Food Science and Technology | 2008
Chang-Ho Jeong; Sung-Gil Choi; Ho-Jin Heo
Journal of The Korean Society of Food Science and Nutrition | 2006
Chang-Ho Jeong; Jin-Hee Kim; Ki-Hwan Shim
Korean Journal of Food Preservation | 2007
Chang-Ho Jeong; Jin-Hee Kim; Jeong-Rai Cho; Cheol-Gun Ahn; Ki-Hwan Shim
Journal of The Korean Society of Food Science and Nutrition | 2006
Chang-Ho Jeong; Ki-Hwan Shim