Christopher L. Lynch
Merck & Co.
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Publication
Featured researches published by Christopher L. Lynch.
Bioorganic & Medicinal Chemistry Letters | 2002
Christopher L. Lynch; Jeffrey J. Hale; Richard J. Budhu; Amy Gentry; Sander G. Mills; Kevin T. Chapman; Malcolm Maccoss; Lorraine Malkowitz; Martin S. Springer; Sandra L. Gould; Julie A. DeMartino; Salvatore J. Siciliano; Margaret A. Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A. Schleif; Renee Danzeisen; Daria J. Hazuda; Joseph Kessler; Janet Lineberger; Michael D. Miller; Emilio A. Emini
A series of alpha-(pyrrolidin-1-yl)acetic acids is presented as selective and potent antivirals against HIV. Several of the pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over pyrrolidine 1.
Bioorganic & Medicinal Chemistry Letters | 2002
Christopher L. Lynch; Amy Gentry; Jeffrey J. Hale; Sander G. Mills; Malcolm Maccoss; Lorraine Malkowitz; Martin S. Springer; Sandra L. Gould; Julie A. DeMartino; Salvatore J. Siciliano; Margaret A. Cascieri; George A. Doss; Anthony Carella; Gwen Carver; Karen Holmes; William A. Schleif; Renee Danzeisen; Daria J. Hazuda; Joseph Kessler; Janet Lineberger; Michael D. Miller; Emilio A. Emini
A series of CCR5 antagonists containing bicyclic isoxazolidines was generated through a nitrone mediated cycloaddition with olefins bearing the preferred pharmacophores previously described. Potent antagonists (3 and 16) were generated with enhanced affinity for the CCR5 receptor while maintaining antiviral activity against HIV.
Bioorganic & Medicinal Chemistry Letters | 2003
Christopher L. Lynch; Christopher A. Willoughby; Jeffrey J. Hale; Edward J. Holson; Richard J. Budhu; Amy Gentry; Keith G. Rosauer; Charles G. Caldwell; Ping Chen; Sander G. Mills; Malcolm Maccoss; Scott C. Berk; Liya Chen; Kevin T. Chapman; Lorraine Malkowitz; Martin S. Springer; Sandra L. Gould; Julie A. DeMartino; Salvatore J. Siciliano; Margaret A. Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A. Schleif; Renee Danzeisen; Daria J. Hazuda; Joseph Kessler; Janet Lineberger; Michael D. Miller; Emilio A. Emini
The 4-(3-phenylprop-1-yl)piperidine moiety of the 1,3,4-trisubstituted pyrrolidine CCR5 antagonist 1 was modified with electron deficient aromatics as well as replacement of the benzylic methylene with sulfones, gem-difluoromethylenes and alcohols in an effort to balance the antiviral potency with reasonable pharmacokinetics.
Science | 2002
Suzanne M. Mandala; Richard Hajdu; James D. Bergstrom; Elizabeth J. Quackenbush; Jenny Xie; James A. Milligan; Rosemary A. Thornton; Gan-Ju Shei; Deborah Card; CarolAnn Keohane; Mark Rosenbach; Jeffrey J. Hale; Christopher L. Lynch; Kathleen M. Rupprecht; William H. Parsons; Hugh Rosen
Archive | 2000
Jeffrey J. Hale; Christopher L. Lynch; Charles G. Caldwell; Christopher A. Willoughby; Dooseop Kim; Dong-Ming Shen; Sander G. Mills; Kevin T. Chapman; Liya Chen; Amy Gentry; Malcolm Maccoss; Zenon Konteatis
Archive | 1998
Richard J. Budhu; Edward Holson; Jeffrey J. Hale; Christopher L. Lynch; Malcolm Maccoss; Scott C. Berk; Sander G. Mills; Christopher A. Willoughby
Archive | 2003
Robert L. Bugianesi; George Doherty; Amy Gentry; Jeffrey J. Hale; Christopher L. Lynch; Sander G. Mills; William E. Neway
Bioorganic & Medicinal Chemistry Letters | 2005
Dooseop Kim; Liping Wang; Jeffrey J. Hale; Christopher L. Lynch; Richard J. Budhu; Malcolm Maccoss; Sander G. Mills; Lorraine Malkowitz; Sandra L. Gould; Julie A. DeMartino; Martin S. Springer; Daria J. Hazuda; Michael D. Miller; Joseph Kessler; Renee Hrin; Gwen Carver; Anthony Carella; Karen Henry; Janet Lineberger; William A. Schleif; Emilio A. Emini
Journal of Medicinal Chemistry | 2005
Zhen Li; Weirong Chen; Jeffrey J. Hale; Christopher L. Lynch; Sander G. Mills; Richard Hajdu; Carol Ann Keohane; Mark Rosenbach; James A. Milligan; Gan-Ju Shei; Gary Chrebet; Stephen A. Parent; James D. Bergstrom; Deborah Card; Michael J. Forrest; Elizabeth J. Quackenbush; L. Alexandra Wickham; Hugo M. Vargas; Rose M. Evans; and Hugh Rosen; Suzanne M. Mandala
Archive | 2003
Weirong Chen; Jeffrey J. Hale; Zhen Li; Christopher L. Lynch; Sander G. Mills; William E. Neway