William E. Neway
Merck & Co.
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Publication
Featured researches published by William E. Neway.
Journal of Leukocyte Biology | 2005
Kalpit A. Vora; Elizabeth A. Nichols; Gene Porter; Yan Cui; Carol Ann Keohane; Richard Hajdu; Jeffery Hale; William E. Neway; Dennis M. Zaller; Suzanne M. Mandala
FTY720 is an immunosuppressive agent that modulates lymphocyte trafficking. It is phosphorylated in vivo to FTY720‐phosphate (FTY‐P) and binds to a family of G protein‐coupled receptors recognizing sphingosine 1‐phosphate (S1P) as the natural ligand. It has previously been reported that FTY‐P blocks egress of lymphocytes from the thymus and lymph nodes, resulting in peripheral blood lymphopenia. We now report that FTY‐P also causes displacement of marginal zone (MZ) B cells to the splenic follicles, an effect that is similar to that observed after in vivo administration of lipopolysaccharide. This effect is specific to B cells in the MZ, as treatment with FTY‐P does not cause redistribution of the resident macrophage population. A small but statistically significant decrease in the expression of β1 integrin on MZ B cells was observed with FTY‐P treatment. The redistribution of MZ B cells from the MZ sinuses does not abolish the ability of these cells to respond to the T‐independent antigen, trinitrophenol‐Ficoll. It has been proposed that the displacement of MZ B cells to the follicles is an indication of cell activation. Consistent with this, FTY‐P caused an increase in percentage of MZ B cells expressing activation markers CD9, CD1d, and CD24. These results suggest that S1P receptors on MZ B cells are responsible for their mobilization to follicles.
Journal of Pharmacology and Experimental Therapeutics | 2001
Masayo Yamazaki; William E. Neway; Tomoyuki Ohe; I-Wu Chen; Janice Rowe; Jerome H. Hochman; Masato Chiba; Jiunn H. Lin
Archive | 2003
Robert L. Bugianesi; George Doherty; Amy Gentry; Jeffrey J. Hale; Christopher L. Lynch; Sander G. Mills; William E. Neway
Archive | 2003
Weirong Chen; Jeffrey J. Hale; Zhen Li; Christopher L. Lynch; Sander G. Mills; William E. Neway
Journal of Medicinal Chemistry | 2004
Jeffrey J. Hale; Christopher L. Lynch; William E. Neway; Sander G. Mills; Richard Hajdu; Carol Ann Keohane; Mark Rosenbach; James A. Milligan; Gan-Ju Shei; Stephen A. Parent; Gary Chrebet; James D. Bergstrom; Deborah Card; Marc Ferrer; Peter Hodder; Berta Strulovici; Hugh Rosen; Suzanne M. Mandala
Archive | 2004
Vincent J. Colandrea; George Doherty; Jeffrey J. Hale; Christopher L. Lynch; Sander G. Mills; William E. Neway; Leslie Toth
Bioorganic & Medicinal Chemistry Letters | 2004
Jeffrey J. Hale; William E. Neway; Sander G. Mills; Richard Hajdu; Carol Ann Keohane; Mark Rosenbach; James A. Milligan; Gan-Ju Shei; Gary Chrebet; James D. Bergstrom; Deborah Card; Gloria C. Koo; Sam L. Koprak; Jesse J. Jackson; Hugh Rosen; Suzanne M. Mandala
Drug Metabolism and Disposition | 2001
Masato Chiba; Lixia Jin; William E. Neway; Joseph P. Vacca; James R. Tata; Kevin T. Chapman; Jiunn H. Lin
Archive | 2003
Richard J. Budhu; George Doherty; Jeffrey J. Hale; Christopher L. Lynch; Sander G. Mills; William E. Neway
Bioorganic & Medicinal Chemistry | 2004
Jeffrey J. Hale; Lin Yan; William E. Neway; Richard Hajdu; James D. Bergstrom; James A. Milligan; Gan-Ju Shei; Gary Chrebet; Rosemary A. Thornton; Deborah Card; Mark Rosenbach; HughRosen; Suzanne M. Mandala