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Dive into the research topics where Christopher Oalmann is active.

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Featured researches published by Christopher Oalmann.


Nature Communications | 2015

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.

Han Dai; April Case; Thomas V. Riera; Thomas Considine; Jessica E. Lee; Yoshitomo Hamuro; Huizhen Zhao; Yong Jiang; Sharon Sweitzer; Beth Pietrak; Benjamin J. Schwartz; Charles A. Blum; Jeremy S. Disch; Richard Caldwell; Bruce G. Szczepankiewicz; Christopher Oalmann; Pui Yee Ng; Brian H. White; Rebecca L. Casaubon; Radha Narayan; Karsten Koppetsch; Francis Bourbonais; Bo Wu; Junfeng Wang; Dongming Qian; Fan Jiang; Cheney Mao; Minghui Wang; Erding Hu; Joseph Wu

SIRT1, the founding member of the mammalian family of seven NAD+-dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended N- and C-terminal regions. We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural elements required for lysine deacetylation and catalytic activation by small molecule sirtuin-activating compounds (STACs). Using this construct, we solved the crystal structure of a mini-hSIRT1-STAC complex, which revealed the STAC-binding site within the N-terminal domain of hSIRT1. Together with hydrogen-deuterium exchange mass spectrometry (HDX-MS) and site-directed mutagenesis using full-length hSIRT1, these data establish a specific STAC-binding site and identify key intermolecular interactions with hSIRT1. The determination of the interface governing the binding of STACs with human SIRT1 facilitates greater understanding of STAC activation of this enzyme, which holds significant promise as a therapeutic target for multiple human diseases.


Archive | 2009

Thiazolopyridine sirtuin modulating compounds

Christopher Oalmann; Jeremy S. Disch; Pui Yee Ng; Robert B. Perni


Archive | 2009

QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS

Chi B. Vu; Christopher Oalmann; Robert B. Perni; Brian White


Archive | 2008

Amide derivatives as sirtuin modulators

Christopher Oalmann; Robert B. Perni; Jeremy S. Disch; Bruce G. Szczepankiewicz; Giovanna Gualtieri; Rebecca L. Casaubon; Karsten Koppetsch


Archive | 2009

Chromenone analogs as sirtuin modulators

Christopher Oalmann; Robert B. Perni; Chi B. Vu


Letters in Drug Design & Discovery | 2013

The Identification of the SIRT1 Activator SRT2104 as a Clinical Candidate

Pui Yee Ng; Jean E. Bemis; Jeremy S. Disch; Chi B. Vu; Christopher Oalmann; Amy V. Lynch; David Carney; Thomas V. Riera; Jeffrey Song; Jesse J. Smith; Siva Lavu; Angela Tornblom; Meghan Duncan; Marie Yeager; Kristina Kriksciukaite; Akanksha Gupta; Vipin Suri; Peter J. Elliot; Jill Milne; Joseph J. Nunes; Michael R. Jirousek; George P. Vlasuk; James L. Ellis; Robert B. Perni


Archive | 2017

aza-heterociclos bicíclos substituídos como modulares de sirtuína

Chi B. Vu; Christopher Oalmann; Radha Narayan; Rebecca L. Casaubon


Archive | 2015

QUINAZOLINONE OR QUINOLONE AS SIRTUIN MODULATOR AND ANALOGUE ASSOCIATED THEREWITH

Vu Chi B; Christopher Oalmann; Pernie Robert B; Brian White


Archive | 2009

Thiazolopyridine compounds sirtuin modulators

Christopher Oalmann; Jeremy S. Disch; Pui Yee Ng; Robert B. Perni


Archive | 2009

Chromenonanaloge als sirtuin-modulatoren

Christopher Oalmann; Robert B. Perni; Chi B. Vu

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