Christopher Oalmann
GlaxoSmithKline
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Publication
Featured researches published by Christopher Oalmann.
Nature Communications | 2015
Han Dai; April Case; Thomas V. Riera; Thomas Considine; Jessica E. Lee; Yoshitomo Hamuro; Huizhen Zhao; Yong Jiang; Sharon Sweitzer; Beth Pietrak; Benjamin J. Schwartz; Charles A. Blum; Jeremy S. Disch; Richard Caldwell; Bruce G. Szczepankiewicz; Christopher Oalmann; Pui Yee Ng; Brian H. White; Rebecca L. Casaubon; Radha Narayan; Karsten Koppetsch; Francis Bourbonais; Bo Wu; Junfeng Wang; Dongming Qian; Fan Jiang; Cheney Mao; Minghui Wang; Erding Hu; Joseph Wu
SIRT1, the founding member of the mammalian family of seven NAD+-dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended N- and C-terminal regions. We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural elements required for lysine deacetylation and catalytic activation by small molecule sirtuin-activating compounds (STACs). Using this construct, we solved the crystal structure of a mini-hSIRT1-STAC complex, which revealed the STAC-binding site within the N-terminal domain of hSIRT1. Together with hydrogen-deuterium exchange mass spectrometry (HDX-MS) and site-directed mutagenesis using full-length hSIRT1, these data establish a specific STAC-binding site and identify key intermolecular interactions with hSIRT1. The determination of the interface governing the binding of STACs with human SIRT1 facilitates greater understanding of STAC activation of this enzyme, which holds significant promise as a therapeutic target for multiple human diseases.
Archive | 2009
Christopher Oalmann; Jeremy S. Disch; Pui Yee Ng; Robert B. Perni
Archive | 2009
Chi B. Vu; Christopher Oalmann; Robert B. Perni; Brian White
Archive | 2008
Christopher Oalmann; Robert B. Perni; Jeremy S. Disch; Bruce G. Szczepankiewicz; Giovanna Gualtieri; Rebecca L. Casaubon; Karsten Koppetsch
Archive | 2009
Christopher Oalmann; Robert B. Perni; Chi B. Vu
Letters in Drug Design & Discovery | 2013
Pui Yee Ng; Jean E. Bemis; Jeremy S. Disch; Chi B. Vu; Christopher Oalmann; Amy V. Lynch; David Carney; Thomas V. Riera; Jeffrey Song; Jesse J. Smith; Siva Lavu; Angela Tornblom; Meghan Duncan; Marie Yeager; Kristina Kriksciukaite; Akanksha Gupta; Vipin Suri; Peter J. Elliot; Jill Milne; Joseph J. Nunes; Michael R. Jirousek; George P. Vlasuk; James L. Ellis; Robert B. Perni
Archive | 2017
Chi B. Vu; Christopher Oalmann; Radha Narayan; Rebecca L. Casaubon
Archive | 2015
Vu Chi B; Christopher Oalmann; Pernie Robert B; Brian White
Archive | 2009
Christopher Oalmann; Jeremy S. Disch; Pui Yee Ng; Robert B. Perni
Archive | 2009
Christopher Oalmann; Robert B. Perni; Chi B. Vu