Chunling Shi

Efficient One-Pot Synthesis of Spirooxindole Derivatives Catalyzed by l-Proline in Aqueous Medium

An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported. This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation.

Highly Regioselective Synthesis of Polysubstituted Pyrroles through Three-Component Reaction Induced by Low-Valent Titanium Reagent

1,2,3,5-Tetrasubstituted and 1,2,3,4,5-pentasubstituted pyrroles may be synthesized through three-component reaction of 1,3-diketones, aldehydes, and amines induced by low-valent titanium reagent. High regioselectivity was achieved. Compared with the classical synthetic method, this new method has the advantages of short reaction time (15 min), high yields, convenient manipulation, and high regioselectivity.

Regioselective synthesis and in vitro anticancer activity of 4-aza-podophyllotoxin derivatives catalyzed by L-proline.

A series of 4-aza-podophyllotoxin derivatives have been synthesized regioselectively via the three-component reaction of aldehydes, aromatic amines, and tetronic acid catalyzed by l-proline. This method has the advantages of high yield, high regioselectivity, extensive adaptability, easy operation, and environmental friendliness. These compounds were also investigated in vitro, and some were found to have good anticancer activity.

A three-component synthesis of N-substituted quinoline-3-carbonitrile derivatives catalysed by L-proline

A series of new N-substituted quinoline-3-carbonitrile derivatives were synthesised by the three-component reaction of N-substituted 5,5-dimethyl-3-aminocyclohex-2-enone, an arylaldehyde, and malononitrile catalysed by l-proline in ethanol at 80°C.

A novel reductive cross-coupling reaction of 2-nitrobenzoic hydrazides and aldehydes or ketones promoted by the low-valence titanium reagent: an access to 2,3,4,5-tetrahydro-1H-1,3,4-benzotriazepine-5-one derivatives

A short and facile synthesis of a series of 2,3,4,5-tetrahydro-1H-1,3,4-benzotriazepine-5-one derivatives was accomplished in good yields via the intermolecular reductive coupling reaction of 2-nitrobenzoic hydrazides and aldehydes or ketones promoted by the low-valence titanium reagent (TiCl4/Zn system). Structures were established on the basis of elemental analysis, IR and 1H NMR spectra.