Xiang-Shan Wang

Synthesis of quinazolin-4(3H)-ones and 1,2-dihydroquinazolin-4(3H)-ones with the aid of a low-valent titanium reagent

Abstract A short and facile synthesis of a series of quinazolin-4(3H)-ones and 1,2-dihydroquinazolin-4(3H)-ones was accomplished in good yields via the novel reductive cyclization of o-nitrobenzamides and triethyl orthoformate, aldehydes or ketones promoted by TiCl4/Zn.

Three‐Component One‐Pot Synthesis of 1,4‐Dihydropyrano[2,3‐c]pyrazole Derivatives in Aqueous Media

Abstract 6‐Amino‐5‐cyano‐4‐aryl‐1,4‐dihydropyrano[2,3‐c]pyrazoles were synthesized by three‐component reaction of aromatic aldehydes, malononitrile, and 3‐methyl‐1‐phenyl‐2‐pyrazolin‐5‐one using triethylbenzylammonium chloride (TEBA) as catalyst in aqueous media. The reaction has the advantages of good yield, less pollution, ease of separation, and of being environment friendly.

One-pot synthesis of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-1- benzopyran-3-carbonitriles in aqueous media

The reaction of aromatic aldehyde, malononitrile and 1,3-cyclohexanediones in water in the presence of triethylbenzyl-ammonium chloride (TEBA) provides an efficient access to 3-cyano-substituted 2-amino-4-aryl-4,6,7,8-tetrahydro-5H-1-benzopyran-5-ones.

Synthesis of 2-Arylquinazolin-4(3H)-one Derivatives Catalyzed by Iodine in [bmim+][ ]

Controlling selectivity of the reactions of aromatic aldehydes and 2-aminobenzamide in ionic liquid catalyzed by iodine at either room temperature or at 80 °C under nitrogen resulted in the synthesis of (E)-Schiff bases, 2,3-dihydro-2-arylquinazolin-4(1H)-one and 2-arylquinazolin-4(3H)-one derivatives, in excellent yields.

Green Synthesis of Quinazolinone Derivatives Catalyzed by Iodine in Ionic Liquid

Abstract A series of quinazolinone derivatives were synthesized by the reaction of 2-aminobenzamides and triethyl orthoformate or triphosgene in ionic liquid of [BMIm]BF4 at 80 °C catalyzed by iodine in good yields. Compared to other methods, this new procedure has the advantages of mild reaction conditions, good yields, operational simplicity, and environmentally friendly procedure. GRAPHICAL ABSTRACT

Iodine-Catalyzed Synthesis of 3-Arylbenzoquinoline Derivatives by Three-Component Reactions

Abstract A mild, efficient, and general method for the synthesis of benzo[f]quinoline derivatives via three-component reaction of arylaldehyde, naphthalen-2-amine, and acetone or acetophenone is described using iodine as catalyst. The features of this procedure are mild reaction conditions, high yields, and operational simplicity.

Green Method for the Synthesis of Benzo[f]pyrimido[4,5-b]quinoline Derivatives Catalyzed by Iodine in Aqueous Media

Abstract A convenient one-pot synthesis of benzo[f]pyrimido[4,5-b]quinoline derivatives is described via three-component reaction of benzaldehydes, naphthalen-2-amine, and barbituric acid at room temperature in aqueous media catalyzed by iodine. Compared with other methods, this three-component reaction used a green solvent, gave good yields, and was operationally simple.

Ionic Liquid–Mediated One-Pot Synthesis of 5-(Trifluoromethyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine Derivatives

Abstract A facile one-pot synthesis of 5-(trifluoromethyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine derivatives is described via a three-component reaction of aldehydes with 5-aminotetrazole and ethyl 4,4,4-trifluoro-3-oxobutanoate or 4,4,4-trifluoro-1-phenylbutane-1,3-dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, good yields, ecofriendliness, and recyclability of the solvent. GRAPHICAL ABSTRACT

Simple Procedure for the Synthesis of 5,7-Diarylpyrido[2,3-d]pyrimidine Derivatives catalyzed by KF-Alumina

Abstract A simple KF/Al2O3-catalyzed reaction of 1,3-diaryl-2-propen-1-one and 2,6-diamino-4-hydroxylpyrimidine in ethyl alcohol gave aromatized 5,7-diarylpyrido[2,3-d]pyrimidine derivative by air oxidation. On the other hand, the unaromatized intermediate products were isolated under dry nitrogen successfully. A possible reaction mechanism with two pathways to lose water was proposed based on the further experimental results; one of them was confirmed by 1H NMR spectra of isolated intermediate product.

A convenient and clean procedure for the synthesis of pyran derivatives in aqueous media catalysed by TEBAC

A clean and simple synthesis of 6-amino-5-cyano-4-aryl-2-methyl-4H-pyran-3-carboxylate derivatives was accomplished in high yields via the reaction of arylmethylidenemalononitriles with acetoacetate in aqueous media catalysed by triethylbenzylammonium chloride (TEBAC). The structures were established by spectroscopic data and further confirmed by X-ray analysis.