Daniel La
Amgen
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Publication
Featured researches published by Daniel La.
ACS Medicinal Chemistry Letters | 2012
Matthew R. Kaller; Scott Harried; Brian K. Albrecht; Patricia Amarante; Safura Babu-Khan; Michael D. Bartberger; James Brown; Ryan Brown; Kui Chen; Yuan Cheng; Martin Citron; Michael Croghan; Russell Graceffa; Dean Hickman; Ted Judd; Chuck Kriemen; Daniel La; Vivian Li; Patricia Lopez; Yi Luo; Craig E. Masse; Holger Monenschein; Thomas Nguyen; Lewis D. Pennington; Tisha San Miguel; E. Allen Sickmier; Robert C. Wahl; Matthew Weiss; Paul H. Wen; Toni Williamson
β-Secretase inhibitors are potentially disease-modifying treatments for Alzheimers disease. Previous efforts in our laboratory have resulted in hydroxyethylamine-derived inhibitors such as 1 with low nanomolar potency against β-site amyloid precursor protein cleaving enzyme (BACE). When dosed intravenously, compound 1 was also shown to significantly reduce Aβ40 levels in plasma, brain, and cerebral spinal fluid. Herein, we report further optimizations that led to the discovery of inhibitor 16 as a novel, potent, and orally efficacious BACE inhibitor.
Archive | 2006
Tae-Seong Kim; David Bauer; Steven Bellon; Alessandro Boezio; Shon Booker; Deborah Choquette; Derin C. D'amico; Noel D'angelo; Celia Dominguez; Ingrid M. Fellows; Julie Germain; Russell Graceffa; Jean-Christophe Harmange; Satoko Hirai; Daniel La; Matthew R. Lee; Longbin Liu; Mark H. Norman; Michele Potashman; Philip Roveto; Aaron C. Siegmund; Ning Xi; Kevin Yang
Archive | 2006
Tae-Seong Kim; David Bauer; Steven Bellon; Alessandro Boezio; Shon Booker; Deborah Choquette; Derin C. D'amico; Noel D'angelo; Celia Dominguez; Ingrid M. Fellows; Julie Germain; Russell Graceffa; Jean-Christophe Harmange; Satoko Hirai; Daniel La; Matthew R. Lee; Longbin Liu; Mark H. Norman; Michele Potashman; Philip Roveto; Aaron C. Siegmund; Ning Xi; Kevin Yang
Archive | 2006
Brian K. Albrecht; Denise Lyn Andersen; Michael D. Bartberger; James Brown; Ryan Brown; Stuart C. Chaffee; Yuan Cheng; Michael Croghan; Russell Graceffa; Scott Harried; Stephen A. Hitchcock; Randall W. Hungate; Ted Judd; Matthew R. Kaller; Charles Kreiman; Daniel La; Patricia Lopez; Craig E. Masse; Holger Monenschein; Thomas Nguyen; Thomas Nixey; Vinod F. Patel; Lewis D. Pennington; Matthew Weiss; Qiufen Xue; Bryant Yang; Wenge Zhong
Archive | 2010
Alessandro Boezio; Alan C. Cheng; James R. Coats; Katrina W. Copeland; Russell Graceffa; Jean-Christophe Harmange; Hongbing Huang; Daniel La; Philip R. Olivieri; Emily A. Peterson; Laurie B. Schenkel
Archive | 2013
Christiane Boezio; Alessandro Boezio; Howard Bregman; Nagasree Chakka; James R. Coats; Katrina W. Copeland; Erin F. DiMauro; Thomas Dineen; Hua Gao; Daniel La; Isaac E. Marx; Hanh Nho Nguyen; Emily A. Peterson; Matthew Weiss
Archive | 2012
Christiane Boezio; Howard Bregman; James R. Coats; Erin F. DiMauro; Thomas Dineen; Bingfan Du; Russell Graceffa; Charles Kreiman; Daniel La; Isaac E. Marx; Nagasree Chakka; Hanh Nho Nguyen; Emily A. Peterson; Matthew Weiss; Katrina W. Copeland; Holly L. Deak; Alessandro Boezio
Archive | 2011
Tae-Seong Kim; David Bauer; Steven Bellon; Alessadro Boezio; Shon Booker; Deborah Choquette; Derin C. D'amico; Noel D'angelo; Celia Dominguez; Ingrid M. Fellows; Julie Germain; Russell Graceffa; Jean-Christophe Harmange; Satoko Hirai; Daniel La; Matthew R. Lee; Longbin Liu; Mark H. Norman; Michele Potashman; Philip Roveto; Aaron C. Siegmund; Ning Xi; Kevin Yang
Archive | 2010
Christiane Bode; Alessandro Boezio; Alan C. Cheng; Deborah Choquette; James R. Coats; Katrina W. Copeland; Hongbing Huang; Daniel La; Richard T. Lewis; Hongyu Liao; Michele Potashman; John Stellwagen; Shuyan Yi; Mark H. Norman; Markian Stec; Emily A. Peterson; Russell Graceffa
Archive | 2009
Ryan White; Albert Amegadzie; Marian C. Bryan; Jian Jeffrey Chen; Alan C. Cheng; Thomas Dineen; Oleg Epstein; Vijay Keshav Gore; Zihao Hua; Jason Brooks Human; Hongbing Huang; Charles Kreiman; Daniel La; Qingyian Liu; Vu Van Ma; Isaac E. Marx; Vinod F. Patel; Wenyuan Qian; Matthew Weiss; Chester Chenguang Yuan
