Daniela Dalpubel

RELATIONSHIP BETWEEN COGNITIVE DISORDER AND METABOLIC SYNDROME IN ELDERS IN A BRAZILIAN COMMUNITY

Renata Bezerra Ara ujo, Daniela Dalpubel, Estela B. Ribeiro, Mariana Luciano Almeida, Francisco Assis Carvalho Vale, Juliana H. Ansai, Federal University of S~ao Carlos, S~ao Carlos, SP, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; University of S~ao Paulo, Ribeir~ao Preto, Brazil; Federal University of S~ao Carlos (UFSCar) Universidade Federal de S~ao Carlos, S~ao Carlos, Brazil. Contact e-mail: renata_bza@hotmail.com

Percepção da perda auditiva: utilização da escala subjetiva de faces para triagem auditiva em idosos

Presbycusis is a disorder present among the elderly. However, it is under-diagnosed, making it important to develop and enhance simple screening tools. OBJECTIVE The subjective faces scale has been proposed as a method to assess auditory self-perception among the elderly, and its correlation with audiological tests. METHODS We looked at elderly patients referred to the audiology service of a reference center for the care of the elderly in a public university hospital between February and November 2013. Patients were submitted to meatoscopy, tonal and vocal audiometry and the whisper test. They also answered the subjective faces scale. A total of 164 elderly individuals participated, and the average age was 77. RESULTS We found a good correlation between the subjective faces scale and audiometry thresholds (r = 0.66). Our results show that the faces and hearing loss correlate, with face 1 corresponding to normal hearing, face 2 to mild hearing loss, and face 3 to Grade I moderate hearing loss. When evaluating the psychometric qualities of the subjective faces scale, we found that faces 2 or 3 have good sensitivity and specificity, with the area under the ROC curve being 0.81. CONCLUSION The subjective faces scale seems to be a good, low-cost and easy to use supplementary tool for auditory screening in geriatric services.

DEPRESSIVE AND ANXIOUS SYMPTOMS IN ELDERS WITH MEMORY COMPLAINT: A CLINICAL STUDY

normative data on SAGE and determined that one point be added to the scores when age over 79 and one point be added when education level is 12 years or less. We evaluated the identical test questions in digital format (eSAGE) made for tablet use, adjusted with previously published age and education norms, and determined eSAGE’s association with gold standard clinical assessments. Methods:Subjects aged over 49 were recruited from community and clinic settings. After SAGE screening, subjects were randomly selected to participate in a clinical evaluation including neuropsychological evaluations. Subjects were identified as dementia, MCI, or normal based on standard clinical criteria. Adjusted eSAGE scores were compared to clinical diagnosis. Associations were investigated using Spearman correlations, linear regression, and sensitivity and specificity measures. Results: 66 recruited subjects were 67% female, 11% non-white, and had mean age 75.2 67.3 (SD) years, mean education 15.162.7 years, mean MMSE score 26.962.6 (range: 20-30), mean SAGE score 15.564.5 (4-22), and mean eSAGE score 14.365.0 (2-22). Spearman correlation of SAGE versus eSAGE is 0.882 (p<0.0001); they are related by the formula: eSAGE score 1⁄4 -1.05 + 0.993 SAGE score. Subjects were classified as either dementia (n1⁄421), MCI (n1⁄424), or normal (n1⁄421) based on standard clinical criteria and neuropsychological testing. ROC of eSAGE based on clinical diagnosis showed an area under the curve (AUC) of 0.89; an eSAGE score of 15 or less provided 69% sensitivity and 100% specificity in detecting cognitive impairment (MCI and dementia, n1⁄445) from normal subjects (n1⁄421). eSAGE ROC analysis of normal vs. MCI subjects showed AUC of 0.80; an eSAGE score of 17 or less provided 75% sensitivity and 76% specificity in detecting MCI subjects. Conclusions: Tabletbased eSAGE shows strong association with validated SAGE. MCI subjects typically fall in the 15-17 range using adjusted scores. Both have the advantage of self-administration, brevity, four interchangeable forms, and high sensitivity and specificity in detecting cognitive impairment from normal subjects.

ASSOCIATION BETWEEN MEMORY COMPLAINT AS REPORTED BY INFORMANTS AND COGNITIVE DEFICIT AND SYMPTOMS OF DEPRESSION AND ANXIETY, IN BRAZILIAN ELDERLY

most frequent NPS for bvFTD and mvFTD (64% and 63% respectively) and apathy for the lvFTD (67%). Among the 3 variants, euphoria was the only NPS that shown statistical significance (p1⁄40.02). Regarding the caregiver distress, the most stressful NPS were: bvFTD (depression 74%), lvFTD (apathy 71%) and mvFTD (motor aberrant behavior 50%). The caregiver distress that showed statistical significance between the 3 groups were depression (p1⁄4 <0.001), apathy (p1⁄4 0.05) and Irritability (p1⁄4 0.03). Conclusions: On this study, affective symptoms (such as apathy and depression) generated a higher distress in caregivers of bvFTD and lvFTD patients, meanwhile motor aberrant behavior did it for mvFTD, this could be associated with the etiology of each variant. Although there have been previous reports about apathy and irritability as being high stressors in caregivers of DFT patients, on this study depression/dysphoria also showed statistical significance between the 3 groups of patients. Upon our knowledge, this is one of the few studies that compare between each other the 3 variants of FTD, since most of studies focus only on the bvFTD.

ADAM10 BIOMARKER: RELATIONSHIP WITH MEMORY COMPLAINT AND COGNITIVE DISORDER IN THE ELDERLY

P4-193 ADAM10 BIOMARKER: RELATIONSHIP WITH MEMORY COMPLAINTAND COGNITIVE DISORDER IN THE ELDERLY Mariana Luciano Almeida, Daniela Dalpubel, Estela B. Ribeiro, Renata Bezerra Araujo, Patricia R. Manzine, M arcia R. Cominetti, Francisco Assis Carvalho Vale, University of S~ao Paulo, Ribeir~ao Preto, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; UFSCar Federal University of S~ao Carlos, Laboratory of Biology of Ageing (LABEN), S~ao Carlos, Brazil; Federal University of S~ao Carlos (UFSCar) Universidade Federal de S~ao Carlos, S~ao Carlos, Brazil. Contact e-mail: marialmeida_18@yahoo.com.br

RELATIONSHIP BETWEEN MEMORY COMPLAINT, COGNITIVE DISORDERS AND PHYSICAL VULNERABILITIES IN ELDERLY

COMPLAINT, COGNITIVE DISORDERS AND PHYSICALVULNERABILITIES IN ELDERLY Daniela Dalpubel, Mariana Luciano Almeida, Estela B. Ribeiro, Renata Bezerra de Ara ujo, Marcia R. Cominetti, Francisco Assis Carvalho Vale, Federal University of S~ao Carlos, S~ao Carlos, Brazil; Federal University S~ao Carlos, S~ao Carlos, Brazil; UFSCar-Federal University of S~ao Carlos, Laboratory of Biology of Ageing (LABEN), S~ao Carlos, Brazil. Contact e-mail: danieladalpubel@yahoo.com.br