Mariana Luciano Almeida

Association Between Gait and Dual Task With Cognitive Domains in Older People With Cognitive Impairment

ABSTRACT The authors investigated whether impaired gait and dual-task performances are associated with specific cognitive domains among older people with preserved cognition (PC), mild cognitive impairment (MCI), and mild Alzheimers disease (AD). The sample comprised 40 older adults with PC, 40 with MCI, and 38 with mild AD. The assessment consisted of gait (measured by 10-m walk test and Timed Up and Go Test [TUGT]), dual task (measured by TUGT associated with a cognitive-motor task of calling a phone number), and cognition (domains of the Addenbrooke Cognitive Examination–Revised and Frontal Assessment Battery [FAB]). For data analysis, the Pearson product-moment correlation and the backward stepwise linear regression were conducted. Language, fluency, and visuospatial domains predicted the 10-m walk test measure specifically in PC, MCI, and AD groups. Only the visuospatial domain was independently associated with the TUGT measure in the MCI and AD groups. FAB score, language domain, and FAB score and fluency domain were the strongest predictors for the isolated cognitive-motor task measure in the PC, MCI, and AD groups, respectively. The visuospatial domain was independently associated with the dual-task test measure in all 3 groups. The study findings demonstrate the influence of specific cognitive domains in daily mobility tasks in people with different cognitive profiles.

RELATIONSHIP BETWEEN COGNITIVE DISORDER AND METABOLIC SYNDROME IN ELDERS IN A BRAZILIAN COMMUNITY

Renata Bezerra Ara ujo, Daniela Dalpubel, Estela B. Ribeiro, Mariana Luciano Almeida, Francisco Assis Carvalho Vale, Juliana H. Ansai, Federal University of S~ao Carlos, S~ao Carlos, SP, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; University of S~ao Paulo, Ribeir~ao Preto, Brazil; Federal University of S~ao Carlos (UFSCar) Universidade Federal de S~ao Carlos, S~ao Carlos, Brazil. Contact e-mail: renata_bza@hotmail.com

Studies About Physical Activity Interventions Including Follow-Up Analysis: A Systematic Review

BACKGROUND Some studies have used the follow-up method to analyze real behavioral changes in research involving physical activity (PA) interventions. This has great scientific value; however, it is hard to apply without satisfactory resources and research funding. Little is known about how many studies have used this method to analyze PA interventions in low-income and middle-income countries, especially Brazil. PURPOSE To describe Brazilian studies using follow-up analysis after PA interventions. METHODS A systematic review was performed including Brazilian studies with follow-up analysis after PA interventions; the analyzed papers were from the previous 10 years. The search was carried out in Portuguese, English, and Spanish in the following databases: SciELO, Latin American and Caribbean Health Science Literature, PubMed, and Scopus. The Preferred Reporting Items for Systematic Review and Meta-Analysis method was used. RESULTS In total, 6 of the 7 studies analyzed were from the southeast region, with the intervention time ranging from 2 to 12 months, carrying out follow-up every 5.3 months with 2.2 observations on average. The interventions had a behavioral approach and were generally carried out in universities, hospitals, and ambulatory care. CONCLUSION Studies on PA interventions using follow-up analysis are scarce. Considering the relevance of follow-up studies to measure behavior changes, the results suggest that more studies about this topic are essential in Brazil.

DEPRESSIVE AND ANXIOUS SYMPTOMS IN ELDERS WITH MEMORY COMPLAINT: A CLINICAL STUDY

normative data on SAGE and determined that one point be added to the scores when age over 79 and one point be added when education level is 12 years or less. We evaluated the identical test questions in digital format (eSAGE) made for tablet use, adjusted with previously published age and education norms, and determined eSAGE’s association with gold standard clinical assessments. Methods:Subjects aged over 49 were recruited from community and clinic settings. After SAGE screening, subjects were randomly selected to participate in a clinical evaluation including neuropsychological evaluations. Subjects were identified as dementia, MCI, or normal based on standard clinical criteria. Adjusted eSAGE scores were compared to clinical diagnosis. Associations were investigated using Spearman correlations, linear regression, and sensitivity and specificity measures. Results: 66 recruited subjects were 67% female, 11% non-white, and had mean age 75.2 67.3 (SD) years, mean education 15.162.7 years, mean MMSE score 26.962.6 (range: 20-30), mean SAGE score 15.564.5 (4-22), and mean eSAGE score 14.365.0 (2-22). Spearman correlation of SAGE versus eSAGE is 0.882 (p<0.0001); they are related by the formula: eSAGE score 1⁄4 -1.05 + 0.993 SAGE score. Subjects were classified as either dementia (n1⁄421), MCI (n1⁄424), or normal (n1⁄421) based on standard clinical criteria and neuropsychological testing. ROC of eSAGE based on clinical diagnosis showed an area under the curve (AUC) of 0.89; an eSAGE score of 15 or less provided 69% sensitivity and 100% specificity in detecting cognitive impairment (MCI and dementia, n1⁄445) from normal subjects (n1⁄421). eSAGE ROC analysis of normal vs. MCI subjects showed AUC of 0.80; an eSAGE score of 17 or less provided 75% sensitivity and 76% specificity in detecting MCI subjects. Conclusions: Tabletbased eSAGE shows strong association with validated SAGE. MCI subjects typically fall in the 15-17 range using adjusted scores. Both have the advantage of self-administration, brevity, four interchangeable forms, and high sensitivity and specificity in detecting cognitive impairment from normal subjects.

ASSOCIATION BETWEEN MEMORY COMPLAINT AS REPORTED BY INFORMANTS AND COGNITIVE DEFICIT AND SYMPTOMS OF DEPRESSION AND ANXIETY, IN BRAZILIAN ELDERLY

most frequent NPS for bvFTD and mvFTD (64% and 63% respectively) and apathy for the lvFTD (67%). Among the 3 variants, euphoria was the only NPS that shown statistical significance (p1⁄40.02). Regarding the caregiver distress, the most stressful NPS were: bvFTD (depression 74%), lvFTD (apathy 71%) and mvFTD (motor aberrant behavior 50%). The caregiver distress that showed statistical significance between the 3 groups were depression (p1⁄4 <0.001), apathy (p1⁄4 0.05) and Irritability (p1⁄4 0.03). Conclusions: On this study, affective symptoms (such as apathy and depression) generated a higher distress in caregivers of bvFTD and lvFTD patients, meanwhile motor aberrant behavior did it for mvFTD, this could be associated with the etiology of each variant. Although there have been previous reports about apathy and irritability as being high stressors in caregivers of DFT patients, on this study depression/dysphoria also showed statistical significance between the 3 groups of patients. Upon our knowledge, this is one of the few studies that compare between each other the 3 variants of FTD, since most of studies focus only on the bvFTD.

ADAM10 BIOMARKER: RELATIONSHIP WITH MEMORY COMPLAINT AND COGNITIVE DISORDER IN THE ELDERLY

P4-193 ADAM10 BIOMARKER: RELATIONSHIP WITH MEMORY COMPLAINTAND COGNITIVE DISORDER IN THE ELDERLY Mariana Luciano Almeida, Daniela Dalpubel, Estela B. Ribeiro, Renata Bezerra Araujo, Patricia R. Manzine, M arcia R. Cominetti, Francisco Assis Carvalho Vale, University of S~ao Paulo, Ribeir~ao Preto, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; UFSCar Federal University of S~ao Carlos, Laboratory of Biology of Ageing (LABEN), S~ao Carlos, Brazil; Federal University of S~ao Carlos (UFSCar) Universidade Federal de S~ao Carlos, S~ao Carlos, Brazil. Contact e-mail: marialmeida_18@yahoo.com.br

RELATIONSHIP BETWEEN MEMORY COMPLAINT, COGNITIVE DISORDERS AND PHYSICAL VULNERABILITIES IN ELDERLY

COMPLAINT, COGNITIVE DISORDERS AND PHYSICALVULNERABILITIES IN ELDERLY Daniela Dalpubel, Mariana Luciano Almeida, Estela B. Ribeiro, Renata Bezerra de Ara ujo, Marcia R. Cominetti, Francisco Assis Carvalho Vale, Federal University of S~ao Carlos, S~ao Carlos, Brazil; Federal University S~ao Carlos, S~ao Carlos, Brazil; UFSCar-Federal University of S~ao Carlos, Laboratory of Biology of Ageing (LABEN), S~ao Carlos, Brazil. Contact e-mail: danieladalpubel@yahoo.com.br