Renata Bezerra Araujo

RELATIONSHIP BETWEEN COGNITIVE DISORDER AND METABOLIC SYNDROME IN ELDERS IN A BRAZILIAN COMMUNITY

Renata Bezerra Ara ujo, Daniela Dalpubel, Estela B. Ribeiro, Mariana Luciano Almeida, Francisco Assis Carvalho Vale, Juliana H. Ansai, Federal University of S~ao Carlos, S~ao Carlos, SP, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; University of S~ao Paulo, Ribeir~ao Preto, Brazil; Federal University of S~ao Carlos (UFSCar) Universidade Federal de S~ao Carlos, S~ao Carlos, Brazil. Contact e-mail: renata_bza@hotmail.com

Dependence between cognitive impairment and metabolic syndrome applied to a Brazilian elderly dataset

Globally, the proportion of elderly individuals in the population has increased substantially in the last few decades. However, the risk factors that should be managed in advance to ensure a natural process of mental decline due to aging remain unknown. In this study, a dataset consisting of a Brazilian elderly sample was modelled using a Bayesian Network (BN) approach to uncover connections between cognitive performance measures and potential influence factors. Regarding its structure (a Directed Acyclic Graph), it was investigated the probabilistic dependence mechanism between two variables of medical interest: the suspected risk factor known as Metabolic Syndrome (MetS) and the indicator of mental decline referred to as Cognitive Impairment (CI). In this investigation, the concept known in the context of a BN as D-separation has been employed. Results of the conducted study revealed that the dependence between MetS and Cognitive Variables (CI and its direct determinants) in fact exists and depends on both Body Mass Index (BMI) and age.

THE INFLUENCE OF GENDER IN DEPRESSIVE SYMPTOMS IN ELDERS WITH MEMORY COMPLAINT: RISK FACTORS TO DEMENTIA IN A COMPARATIVE STUDY AND LONGITUDINAL STUDY

P1-658 REPEATED COGNITIVE TESTING REDUCES SAMPLE SIZE NECESSARY TO DETECT CLINICALLY RELEVANT EFFECTS Clive Ballard, Helen Brooker, Zunera Khan, Anne Corbett, Dag Aarsland, Keith Wesnes, University of Exeter Medical School, Exeter, United Kingdom; King’s College London, London, United Kingdom; Wesnes Cognition Ltd, Reading, United Kingdom; Department of Old Age Psychiatry, King’s College London, London, United Kingdom; Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom. Contact e-mail: c.ballard@exeter.ac.uk

SLEEP DISORDERS AND ALZHEIMER'S DISEASE: A CLINICAL EVALUATION

Age, years, mean (SD) 70 (9.0) 69.4 (8.5) 74.2 (6.5) 0.25 Sex, male, N (%) 24 (53.3%) 24 (45.3%) 4 (40.0%) 0.64 Education, years, mean (SD) 17.0 (2.3) 15.8 (2.4) 15.5 (3.0) 0.028 CVLT-II 1-5, mean (SD) 50.0 (10.1) 40.3 (13.5) 29.1(7.3) < 0.001 CVLT-II DR, mean (SD) 10.3 (4.0) 7.1 (5.0) 2.3 (3.7) < 0.001 VR-I copy, mean (SD) 84.7 (11.4) 68.0 (16.9) 42.6 (17.0) < 0.001 VR-II DR, mean (SD) 66.4 (21.2) 38.0 (26.9) 10.8 (24.3) < 0.001 Rey-O copy, mean (SD) 32.0 (2.6) 28.2 (5.9) 24.9 (7.0) < 0.001 Rey-O DR, mean (SD) 20.2 (6.7) 11.3 (7.1) 3.75 (5.3) < 0.001 Poster Presentations: Sunday, July 22, 2018 P415

DEPRESSIVE AND ANXIOUS SYMPTOMS IN ELDERS WITH MEMORY COMPLAINT: A CLINICAL STUDY

normative data on SAGE and determined that one point be added to the scores when age over 79 and one point be added when education level is 12 years or less. We evaluated the identical test questions in digital format (eSAGE) made for tablet use, adjusted with previously published age and education norms, and determined eSAGE’s association with gold standard clinical assessments. Methods:Subjects aged over 49 were recruited from community and clinic settings. After SAGE screening, subjects were randomly selected to participate in a clinical evaluation including neuropsychological evaluations. Subjects were identified as dementia, MCI, or normal based on standard clinical criteria. Adjusted eSAGE scores were compared to clinical diagnosis. Associations were investigated using Spearman correlations, linear regression, and sensitivity and specificity measures. Results: 66 recruited subjects were 67% female, 11% non-white, and had mean age 75.2 67.3 (SD) years, mean education 15.162.7 years, mean MMSE score 26.962.6 (range: 20-30), mean SAGE score 15.564.5 (4-22), and mean eSAGE score 14.365.0 (2-22). Spearman correlation of SAGE versus eSAGE is 0.882 (p<0.0001); they are related by the formula: eSAGE score 1⁄4 -1.05 + 0.993 SAGE score. Subjects were classified as either dementia (n1⁄421), MCI (n1⁄424), or normal (n1⁄421) based on standard clinical criteria and neuropsychological testing. ROC of eSAGE based on clinical diagnosis showed an area under the curve (AUC) of 0.89; an eSAGE score of 15 or less provided 69% sensitivity and 100% specificity in detecting cognitive impairment (MCI and dementia, n1⁄445) from normal subjects (n1⁄421). eSAGE ROC analysis of normal vs. MCI subjects showed AUC of 0.80; an eSAGE score of 17 or less provided 75% sensitivity and 76% specificity in detecting MCI subjects. Conclusions: Tabletbased eSAGE shows strong association with validated SAGE. MCI subjects typically fall in the 15-17 range using adjusted scores. Both have the advantage of self-administration, brevity, four interchangeable forms, and high sensitivity and specificity in detecting cognitive impairment from normal subjects.

ASSOCIATION BETWEEN MEMORY COMPLAINT AS REPORTED BY INFORMANTS AND COGNITIVE DEFICIT AND SYMPTOMS OF DEPRESSION AND ANXIETY, IN BRAZILIAN ELDERLY

most frequent NPS for bvFTD and mvFTD (64% and 63% respectively) and apathy for the lvFTD (67%). Among the 3 variants, euphoria was the only NPS that shown statistical significance (p1⁄40.02). Regarding the caregiver distress, the most stressful NPS were: bvFTD (depression 74%), lvFTD (apathy 71%) and mvFTD (motor aberrant behavior 50%). The caregiver distress that showed statistical significance between the 3 groups were depression (p1⁄4 <0.001), apathy (p1⁄4 0.05) and Irritability (p1⁄4 0.03). Conclusions: On this study, affective symptoms (such as apathy and depression) generated a higher distress in caregivers of bvFTD and lvFTD patients, meanwhile motor aberrant behavior did it for mvFTD, this could be associated with the etiology of each variant. Although there have been previous reports about apathy and irritability as being high stressors in caregivers of DFT patients, on this study depression/dysphoria also showed statistical significance between the 3 groups of patients. Upon our knowledge, this is one of the few studies that compare between each other the 3 variants of FTD, since most of studies focus only on the bvFTD.

ADAM10 BIOMARKER: RELATIONSHIP WITH MEMORY COMPLAINT AND COGNITIVE DISORDER IN THE ELDERLY

P4-193 ADAM10 BIOMARKER: RELATIONSHIP WITH MEMORY COMPLAINTAND COGNITIVE DISORDER IN THE ELDERLY Mariana Luciano Almeida, Daniela Dalpubel, Estela B. Ribeiro, Renata Bezerra Araujo, Patricia R. Manzine, M arcia R. Cominetti, Francisco Assis Carvalho Vale, University of S~ao Paulo, Ribeir~ao Preto, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; Federal University of S~ao Carlos, S~ao Carlos, Brazil; UFSCar Federal University of S~ao Carlos, Laboratory of Biology of Ageing (LABEN), S~ao Carlos, Brazil; Federal University of S~ao Carlos (UFSCar) Universidade Federal de S~ao Carlos, S~ao Carlos, Brazil. Contact e-mail: marialmeida_18@yahoo.com.br

RELATIONSHIP BETWEEN MEMORY COMPLAINT, COGNITIVE DISORDERS AND PHYSICAL VULNERABILITIES IN ELDERLY

COMPLAINT, COGNITIVE DISORDERS AND PHYSICALVULNERABILITIES IN ELDERLY Daniela Dalpubel, Mariana Luciano Almeida, Estela B. Ribeiro, Renata Bezerra de Ara ujo, Marcia R. Cominetti, Francisco Assis Carvalho Vale, Federal University of S~ao Carlos, S~ao Carlos, Brazil; Federal University S~ao Carlos, S~ao Carlos, Brazil; UFSCar-Federal University of S~ao Carlos, Laboratory of Biology of Ageing (LABEN), S~ao Carlos, Brazil. Contact e-mail: danieladalpubel@yahoo.com.br