Uday V. Desai

Cellulose supported cuprous iodide nanoparticles (Cell-CuI NPs): a new heterogeneous and recyclable catalyst for the one pot synthesis of 1,4-disubstituted – 1,2,3-triazoles in water

Cellulose supported cuprous iodide nanoparticles (Cell-CuI NPs) have been demonstrated for the first time as an efficient heterogeneous catalyst in the click synthesis of 1,4-disubstituted 1,2,3-triazoles by a one-pot three component reaction between aralkyl/alkyl bromides, alkynes and sodium azide in water. The catalyst has been characterized by XRD, HRTEM, SEM, ICP–AES, EDS as well as IR spectroscopy. It was found to be reusable for five consecutive runs without significant loss of activity.

Tris-hydroxymethylaminomethane (THAM): a novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles

A simple, efficient and environmentally benign protocol has been developed for the one-pot, multicomponent synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles using a commercially available, inexpensive, non-toxic, and biodegradable tris-hydroxymethylaminomethane (THAM) as a novel organocatalyst. Ambient reaction conditions, wide scope, avoidance of conventional isolation as well as purification techniques and the reusability of the catalyst for five consecutive runs have improved the practical utility of this multicomponent reaction protocol manifold.

Nickel ferrite nanoparticles–hydrogen peroxide: a green catalyst-oxidant combination in chemoselective oxidation of thiols to disulfides and sulfides to sulfoxides

Nickel ferrite nanoparticles–hydrogen peroxide has been demonstrated for the first time as a green and efficient catalyst-oxidant combination in the chemoselective oxidation of thiols to disulfides and sulfides to sulfoxides. This magnetically separable catalyst was found to be reusable for five consecutive runs without appreciable change in the activity, as well as composition of the catalyst. The mechanism for the oxidation of thiols and sulfides has also been proposed.

A SIMPLE AND PRACTICAL HALOGENATION OF ACTIVATED ARENES USING POTASSIUM HALIDE AND OXONE® IN WATER-ACETONITRILE MEDIUM

A simple and practical halogenation of activated arenes using a reagent combination of potassium halide and oxone® in water-acetonitrile medium is presented. The halogenated products were obtained with good yields and in high purity.

One Pot Synthesis of Monoalkylated and Mixed, Dialkylated Meldrum's Acid Derivatives

Abstract A simple one pot method, involving sequential Knoevenagel condensation of Meldrums acid with aromatic aldehydes, conjugate reduction of ylidene Meldrums acid using sodium borohydride followed by alkylation, to prepare mixed dialkylated derivatives of Meldrums acid is described.

Heck reaction in aqueous medium using Amberlite IRA-400 (basic)Dedicated to the memory of the Late Dr Nitiraj R. Mane.

Efficient Heck reaction in aqueous medium using Amberlite IRA-400 (basic) as a base is reported.

Anhydrous Magnesium Sulfate Mediated Solvent-Free Synthesis of Dihydropyrimidin-2(1H)-ones at Ambient Temperature

An anhydrous magnesium sulfate mediated solvent-free protocol is described for the synthesis of dihydropyrimidinones (Biginelli compounds) at ambient temperature.

ENVIROCAT EPZ-10: A SOLID ACID CATALYST FOR THE SYNTHESIS OF 1,8-DIOXO-OCTAHYDROXANTHENES IN AQUEOUS MEDIUM

An efficient method for synthesis of 1,8-dioxo-octahydroxanthenes using EPZ-10 as a heterogeneous catalyst is developed. In this method, aldehydes and dimedone / cyclohexane-1,3-dione are heated at 70 °C in the presence of a catalytic amount of EPZ-10 in water as a universal solvent, affording the corresponding 1,8-dioxo-octahydroxanthenes in moderate to excellent yields. Also, domino Knoevenagel / hetero-Michael-addition reaction is described in water without any catalyst with excellent yields. The major advantages of this method are excellent yields, short reaction time, and ease of operation. This green protocol works well with dimedone as well as cyclohexane-1,3-dione.

Potassium phosphate catalyzed nitroaldol reaction

Abstract Potassium phosphate was found to catalyze condensation of nitroalkanes with various aliphatic and aromatic aldehydes to form nitroaldols in excellent yields in acetonitrile medium at room temperature.

Trichloroisocyanuric Acid–Mediated One-Pot Synthesis of Unsymmetrical 2,5-Disubstituted 1,3,4-Oxadiazoles at Ambient Temperature

Abstract An efficient method for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles has been developed using trichloroisocyanuric acid (TCCA) at ambient temperature. A wide variety of aromatic as well as heterocyclic aldehydes exhibit condensation with a variety of acylhydrazines followed by oxidative cyclization to yield corresponding unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol.