Richard J. Sciotti

Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721

Abstract A method for the intermolecular coupling of aryl bromides and oxazolidinones is described. Application to intermediates useful for the preparation of a known class of antibacterial agent and the synthesis of the known antibacterial oxazolidinone Dup-721 are described.

Solid phase synthesis of ureas of secondary amines via carbamoyl chloride

Abstract Secondary amines attached to a solid support such as the Wang resin can be converted to the corresponding carbamoyl chlorides by treatment with phosgene or triphosgene. Further reaction of the resulting carbamoyl chlorides with primary or secondary amines affords ureas in high yield and chemical purity.

Enantioselective synthesis of the top half of chlorothricolide

Abstract Highly enantio- and diastereoselective syntheses of spirotetronates 4 and 5 corresponding to the top half of chlorothricolide are described.