Rolf Gericke

Characterization of a novel K+ channel activator, EMD 52962, in electrophysiological and pharmacological experiments

Introduction Recent publication have indicated that some benzopyran derivatives (e.g. cromakalim) are potent relaxants of a number of smooth muscles. Their main pharmacological properties are most probably related to their ability to hyperpolarize the membranes of smooth muscle cells by increasing the conductance to potassium ions (Hamilton et al. 1986). We have therefore explored the possibility that a newly synthetised derivative, EMD 52692 (4-(1,2-dihydro-2-oxo1 -pyridyl)-2,2-dimethyl-2H1-benzo pyran-6-carbonitrile), also induces vascular relaxation by a similar mechanism.

The transformation of a chromene derivative into benzofurans via allene intermediates

Abstract On LDA-treatment of chromene 1, allenyl phenol 3 is formed which recyclizes in solution. Acetate 4 gives benzofuran derivatives on thermal cyclization.