Digambar Balaji Shinde

New bioactive macrocyclic diterpenoids from Jatropha multifida.

Two new macrocyclic diterpenoids, multifidanol (1) and multifidenol (2) along with several known compounds have been isolated from the stem of Jatropha multifida. The structures of the new compounds were established from the extensive studies of their 1D and 2D NMR spectra. The cytotoxic and antimicrobial activities of these two constituents were examined.

Total synthesis of racemic and (R) and (S)-4-methoxyalkanoic acids and their antifungal activity.

The total synthesis of 4-methoxydecanoic acid and 4-methoxyundecanoic acid in racemic and stereoselective [(R) and (S)] forms has been accomplished. For stereoselective synthesis of the compounds (S) and (R)-BINOL complexes have been used to generate the required chiral centres. The antifungal activity of these compounds has been studied against different organisms and the results were found to be impressive. The activity of the compounds in racemic and in stereoselective forms was compared. (R)-4-Methoxydecanoic acid was found to be most potent (MIC: 0.019 mg/mL against Candida albicans MTCC 227, C. albicans MTCC 4748, Aspergillus brasiliensis (niger) MTCC 281 and Issatchenkia orientalis MTCC 3020).

Novel Approach for the Synthesis of N-Substituted Pyrroles Starting Directly from Nitro Compounds in Water

Abstract A novel approach for a facile high-yielding synthesis of N-substituted pyrroles has been discovered by the treatment of nitroarenes with 2,5-dimethoxytetrahydrofuran using indium in dilute aqueous HCl at room temperature. GRAPHICAL ABSTRACT

A distinct novel approach for the synthesis of 3-indolyl-methanamines starting from indoles, aldehydes and nitrobenzenes in water

3-Indolyl-methanamines have efficiently been synthesized by the treatment of indoles with aldehydes and nitrobenzenes using indium in aqueous HCl at room temperature. The products are formed in excellent yields (91–98%) within a short period of time (30–45 min). Bisindolyl methanes have not been obtained under the present reaction conditions.

Stereoselective Total Synthesis of Proposed Structure of Stagonolide D

The stereoselective total synthesis of the proposed structure of naturally occurring nonenolide stagonolide D has been achieved using D-mannitol as the starting material. The latter has been utilized for the preparation of both the olefinic alcohol segment and the olefinic acid segment of the target molecule. The synthetic sequence involves asymmetric epoxidation and ring-closing metathesis as the key steps.