Jayprakash Narayan Kumar

A new macrocyclic diterpenoid from Jatropha multifida.

A new diterpenoid, 15-epi-(4E)-jatrogrossidentadione acetate, along with several known constituents has been isolated from the stem of Jatropha multifida. The structure of the new compound was settled by a detailed analysis of its 1D- and 2D-NMR spectra.

A new strategy for the synthesis of crucigasterin A, and cytotoxic activity of this compound and its related analogues ☆

Stereoselective total synthesis of bioactive marine natural product crucigasterin A has been accomplished from commercially available and inexpensive L-(-)-malic acid as a starting material. Julia olefination and chelation controlled Grignard additions are the key steps involved in the present synthesis. Cytotoxic properties of crucigasterin A and its related analogues crucigasterins B and D have been evaluated. Crucigasterin A showed promising activities against both the human cervical cancer cell line and human breast adenocarcinoma cell line.

Novel Approach for the Synthesis of N-Substituted Pyrroles Starting Directly from Nitro Compounds in Water

Abstract A novel approach for a facile high-yielding synthesis of N-substituted pyrroles has been discovered by the treatment of nitroarenes with 2,5-dimethoxytetrahydrofuran using indium in dilute aqueous HCl at room temperature. GRAPHICAL ABSTRACT

A distinct novel approach for the synthesis of 3-indolyl-methanamines starting from indoles, aldehydes and nitrobenzenes in water

3-Indolyl-methanamines have efficiently been synthesized by the treatment of indoles with aldehydes and nitrobenzenes using indium in aqueous HCl at room temperature. The products are formed in excellent yields (91–98%) within a short period of time (30–45 min). Bisindolyl methanes have not been obtained under the present reaction conditions.

Stereoselective Total Synthesis of Proposed Structure of Stagonolide D

The stereoselective total synthesis of the proposed structure of naturally occurring nonenolide stagonolide D has been achieved using D-mannitol as the starting material. The latter has been utilized for the preparation of both the olefinic alcohol segment and the olefinic acid segment of the target molecule. The synthetic sequence involves asymmetric epoxidation and ring-closing metathesis as the key steps.

Enantioselective first total synthesis of eujavanoic acid B through organocatalyzed IMDA reaction

The first total synthesis of the polyketide eujavanoic acid B has been accomplished from an easily available and inexpensive starting material 1,3-propane diol. Maruoka asymmetric allylation, Julia olefination, HWE olefination and organocatalyzed intramolecular Diels–Alder reactions are the key steps involved in the present synthesis.