Dong Young Oh

Tetrachlorosilane Catalyzed Dithioacetalization

Abstract Tetrachlorosilane was found to be a mild as well as selective catalyst for dithioacetalization of the carbonyl compounds.

First example of 1,1-bimetalloalkenes of tellurium and zirconium: Application for stereoselective preparation of (Z)-α-organotelluro-α,β-unsaturated carbonyl compounds

Hydrozirconation of acetylenic tellurides 1 affords the first examples of 1,1-bimetalloalkenes of tellurium and zirconium 2. Intermediates 2 are reacted with acyl halides to obtain (Z)-α-organotelluro- α,β-unsaturated carbonyl compounds 4 via ZrCu transmetallation.

One-pot synthesis of primary E-Allylic amines

Abstract The Preparation of Primary E-Allylic Amines is performed in a one-pot procedure by subsequent treatment of lithiomethylphosphonate with nitriles, followed by addition of aldehydes and sodium borohydride.

Synthesis and reaction of β-organyltelluro vinylphosphonates and vinyl sulfones

Abstract Reactions of organyl tellurols generated in situ from ditellurides and alkynes bearing electron-stabilizing groups such as the phosphonyl and sulfonyl groups gave the β-organyltelluro vinylphosphonates or vinyl sulfones in high yield, which are followed by transmetallation by organometallic reagents.

New synthesis of β-keto phosphonates

Abstract A new synthetic route to β-keto phosphonates from diethyl 1-(trimethylsilyl)vinyl-phosphonate 1 is described. This involves nucleophilic addition of the organolithium reagents toward 1 followed by quenching with acid chlorides and alkyl isocyanates.

The stereoselective synthesis of cyclopropylphosphonate analogs of nucleotides

Abstract 1-Alkenylphosphonic acid derivatives of purines have been proven to exhibit significant antiviral activity among these series of compounds. Here we disclose the stereoselective synthesis of the constrained analogs of 1-alkenylphosphonate derivatives of purines via intramolecular epoxide opening reaction of γ,δ-epoxyalkanephosphonates with subsequent Mitsunobu coupling reactions with purine bases.

Stereo- and regioselective preparation of vinyl tellurides via alkenyl zirconocenes

Stereoselective preparation of vinyl tellurides3a-f is described via hydrozirconation / transmetallation using phenyltellurenyl iodide.

One-Pot Synthesis of 1-Alkynylphosphonates

Abstract 1-Alkynylphosphonates 3 are prepared in a one-pot procedure from diethyl phosphorochloridates 2 and alkynyllithiums 1, which are readily generated by the reaction of 1-alkynes with n-BuLi.

Acylation of diethyl (ethoxycarbonyl)fluoromethylphosphonate using magnesium chloride-triethylamine: A facile synthesis of α-fluoro β-keto esters

Abstract A facile synthesis of α-fluoro β-keto esters, via diacylation reaction of diethyl (ethoxycarbonyl)fluoromethylphosphonate with aromatic carboxylic acid chlorides in the presence of magnesium chloride-triethylamine followed by deacylation, is described.

A Convenient One-Pot Synthesis of α-Functionalized α,β-Unsaturated Sulfones

Abstract α -Methoxy α, β-unsaturated sulfones and α -chloro α, β-unsaturated sulfones were conveniently prepared in high yields using one-pot Wittig-Horner reaction from methoxymethyl phenyl sulfone and chloromethyl phenyl sulfone, respectively.