Kilsung Lee

One-pot synthesis of primary E-Allylic amines

Abstract The Preparation of Primary E-Allylic Amines is performed in a one-pot procedure by subsequent treatment of lithiomethylphosphonate with nitriles, followed by addition of aldehydes and sodium borohydride.

Reaction of allyltrimethylsilane with an aromatic compound using hypervalent organoiodine compound: A new allylation of aromatic compounds

Abstract New general method for the allylation of aromatic compounds from allyltrimethylsilane utilizing the combination of iodosylbenzene and BF 3 OEt 2 are described, which is based upon the umpolung of allyltrimethylsilane by way of cationic allylphenyliodonium (III) salt complex as an intermediate.

Synthesis of α-Hetero Atom Substituted β-Keto and Enamine Phosphonates

Abstract Various α-hetero atom substituted β-keto and enamine phosphonates are prepared by the nucleophilic addition of α-lithioanion of diethyl methylphosphonate to nitriles followed by subsequent addition of electrophiles.

Reaction of conjugated nitro olefins with aromatic compounds: a new acylmethylation of aromatic compounds

Abstract Reaction of conjugated nitro olefins with aromatic compounds, followed by hydrolytic treatment, gives acylmethylated aromatic compounds in good yield.

MICHAEL ADDITION OF N-(DIPHENYLMETHYLENE)- AMINOMETHYLPHOSPHONATE TO ACRYLATES USING PHASE TRANSFER CATALYSIS CONDITIONS: SYNTHESIS OF 1-(N-DIPHENYLMETHYLENE)AMINO- 3-(ALKOXYCARBONYL)- PROPYLPHOSPHONATES

Phase transfer catalyzed Michael reaction of N-(diphenyl-methylene)-aminomethylphosphonate 1 to acrylates (2) provides a simple and convenient method for the synthe-sis of 1-(N-diphenylmethylene)amino-3-(alkoxycarbonyl)propylphosphonates (3).

A Facile Method for the Preparation of 1,1-Dichloroolefins Using Benzenesulfonyl Chloride as a Chlorenium Ion Source

Abstract Reaction of the lithio anion derived from diethyl methylphosphonate with benzenesulfonyl chloride gives directly the (diethylphosphoryl)dichloromethyllithium. In situ reaction with aldehydes or ketones gives in high yields of 1,1-dichloroolefins in a convenient one-pot procedure.

New synthetic route to ketene selenoacetals. Reaction of diethyl 1,1-bis(phenylseleno)methylphosphonate with aldehydes and ketones.

Abstract Reaction of 1,1-bis(phenylseleno)methylphosphonate with aldehydes gives ketene selenoacetals quantitatively.

Synthesis of β-Amino Phosphonates in One-Pot Procedure

Abstract: β-amino phosphonate derivatives are synthesized in one-pot procedure via reduction of β-enamino phosphonate intermediates with NaBH4/acetic acid or trifluoroacetic acid.

A One-Pot Generation of α-Chloro-α-Lithio Alkanephosphonates. A New Preparative Route to 1,2-Epoxyalkanephosphonates

Abstract Reaction of lithio anion derived from diethyl alkanephosphonate in the presence of 2 eq. of n-BuLi with benzenesulfonyl chloride gives directly the corresponding diethyl-1-chloro-1-lithioalkanephosphonate, which reacts in situ with carbonyl compounds followed by intramolecular substitution reaction to give 1,2-epoxyalkanephosphonates.

SYNTHESIS OF 3-ALKYL-3-PHOSPHORYL CHROMANONES: TANDEM ALLYL-VINYL MIGRATION AND CYCLIZATION OF α-(O-HYDROXYBENZOYL)-ALLYLIC PHOSPHONATES

2-Alkyl-3-phosphoryl chromanones and its thio-derivatives were synthesized by a tandem allyl-vinyl migration and cyclization of α-(o-hydroxybenzoyl)-allylic phosphonates which were readily produced from lithiated allylic phosphonates and salicylate.