Donhee Ham

Concepts and methods in optimization of integrated LC VCOs

Underlying physical mechanisms controlling the noise properties of oscillators are studied. This treatment shows the importance of inductance selection for oscillator noise optimization. A design strategy centered around an inductance selection scheme is executed using a practical graphical optimization method to optimize phase noise subject to design constraints such as power dissipation, tank amplitude, tuning range, startup condition, and diameters of spiral inductors. The optimization technique is demonstrated through a design example, leading to a 2.4-GHz fully integrated, LC voltage-controlled oscillator (VCO) implemented using 0.35-/spl mu/m MOS transistors. The measured phase-noise values are -121, -117, and -115 dBc/Hz at 600-kHz offset from 1.91, 2.03, and 2.60-GHz carriers, respectively. The VCO dissipates 4 mA from a 2.5-V supply voltage. The inversion mode MOSCAP tuning is used to achieve 26% of tuning range. Two figures of merit for performance comparison of various oscillators are introduced and used to compare this work to previously reported results.

Chip-NMR biosensor for detection and molecular analysis of cells

Rapid and accurate measurement of biomarkers in tissue and fluid samples is a major challenge in medicine. Here we report the development of a new, miniaturized diagnostic magnetic resonance (DMR) system for multiplexed, quantitative and rapid analysis. By using magnetic particles as a proximity sensor to amplify molecular interactions, the handheld DMR system can perform measurements on unprocessed biological samples. We show the capability of the DMR system by using it to detect bacteria with high sensitivity, identify small numbers of cells and analyze them on a molecular level in real time, and measure a series of protein biomarkers in parallel. The DMR technology shows promise as a robust and portable diagnostic device.

Nanotechnology: High-speed integrated nanowire circuits

Macroelectronic circuits made on substrates of glass or plastic could one day make computing devices ubiquitous owing to their light weight, flexibility and low cost. But these substrates deform at high temperatures so, until now, only semiconductors such as organics and amorphous silicon could be used, leading to poor performance. Here we present the use of low-temperature processes to integrate high-performance multi-nanowire transistors into logical inverters and fast ring oscillators on glass substrates. As well as potentially enabling powerful electronics to permeate all aspects of modern life, this advance could find application in devices such as low-cost radio-frequency tags and fully integrated high-refresh-rate displays.

Stretchable Microfluidic Radiofrequency Antennas

www.MaterialsViews.com C O M Stretchable Microfl uidic Radiofrequency Antennas M U N I By Masahiro Kubo , Xiaofeng Li , Choongik Kim , Michinao Hashimoto , Benjamin J. Wiley , Donhee Ham , and George M. Whitesides * C A IO N This paper describes a new method for fabricating stretchable radiofrequency antennas. The antennas consist of liquid metal (eutectic gallium indium alloy, EGaIn [ 1 , 2 ] ) enclosed in elastomeric microfl uidic channels. In particular, a microfl uidic structure made of two types of elastomers (polydimethylsiloxane (PDMS) and Ecofl ex (type 0030, Reynolds Advanced Materials)) with different stiffness has been developed to improve the stretchability and mechanical stability of the antennas. These antennas can be stretched up to a strain [defi ned as the percentage change in length or ( l – l 0 )/ l 0 ] of 120 %. This high stretchability allows the resonance frequencies of the antennas to be mechanically tuned over a wide range of frequencies. The antennas can also be repeatedly stretched, while retaining a high effi ciency (> 95 %) in radiation. “Stretchability” in electronics has the potential to open new opportunities, particularly for large-area devices and systems, and in systems that require the device to conform to a nonplanar surface, or to bend and stretch while in use. [ 3–5 ] Compared to “fl exible” electronics built on nonstretchable polymer or paper substrates, [ 6 , 7 ] stretchable electronics can cover almost arbitrarily curved surfaces and movable parts. Mechanical compliance may increase the comfort of the user for wearable electronics or implantable medical devices, and simplify the integration for a range of applications. [ 3–5 , 8 ] New approaches to stretchable electronics are now being developed. In a recent advance, Rogers et al. [ 4 , 5 ] described stretchable integrated circuits with elongation of up to 100 % using wavy, thin silicon ribbons on pre-stretched elastic substrates. Antennas offer new, attractive applications for stretchable electronics; these applications might include reconfi gurable antennas, [ 9 ] antennas for limited and nonplanar spaces, [ 10 ] and wearable sensors. Two methods are commonly used to build antennas for commercial applications. The most common method uses sheet-metal processing; in this method, a metal sheet is punched, bent, and welded into the desired structure. A second method uses chemical etching and plating to make small patterns of metal. This method can make fl exible antennas by patterning metal on a fl exible substrate. Neither

Mode-Locked Pulses from Mid-Infrared Quantum Cascade Lasers

In this study, we report the unequivocal demonstration of midinfrared mode-locked pulses from quantum cascade lasers. The train of short pulses was generated by actively modulating the current and hence the gain of an edge-emitting quantum cascade laser (QCL). Pulses with duration of about 3 ps at full-width-at-half-maxima and energy of 0.5 pJ were characterized using a second-order interferometric autocorrelation technique based on a nonlinear quantum well infrared photodetector. The mode-locking dynamics in the QCLs was modeled based on the Maxwell-Bloch equations in an open two-level system. Our model reproduces the overall shape of the measured autocorrelation traces and predicts that the short pulses are accompanied by substantial wings as a result of strong spatial hole burning. The range of parameters where short mode-locked pulses can be formed is found.

Integrated cell manipulation system—CMOS/microfluidic hybrid{

Manipulation of biological cells using a CMOS/microfluidic hybrid system is demonstrated. The hybrid system starts with a custom-designed CMOS (complementary metal-oxide semiconductor) chip fabricated in a semiconductor foundry. A microfluidic channel is post-fabricated on top of the CMOS chip to provide biocompatible environments. The motion of individual biological cells that are tagged with magnetic beads is directly controlled by the CMOS chip that generates microscopic magnetic field patterns using an on-chip array of micro-electromagnets. Furthermore, the CMOS chip allows high-speed and programmable reconfiguration of the magnetic fields, substantially increasing the manipulation capability of the hybrid system. Extending from previous work that verified the concept of the hybrid system, this paper reports a set of manipulation experiments with biological cells, which further confirms the advantage of the hybrid approach. To enhance the biocompatibility of the system, the microfluidic channel is redesigned and the temperature of the device is monitored by on-chip sensors. Combining microelectronics and microfluidics, the CMOS/microfluidic hybrid system presents a new model for a cell manipulation platform in biological and biomedical applications.

Vertically integrated, three-dimensional nanowire complementary metal-oxide-semiconductor circuits

Three-dimensional (3D), multi-transistor-layer, integrated circuits represent an important technological pursuit promising advantages in integration density, operation speed, and power consumption compared with 2D circuits. We report fully functional, 3D integrated complementary metal-oxide-semiconductor (CMOS) circuits based on separate interconnected layers of high-mobility n-type indium arsenide (n-InAs) and p-type germanium/silicon core/shell (p-Ge/Si) nanowire (NW) field-effect transistors (FETs). The DC voltage output (Vout) versus input (Vin) response of vertically interconnected CMOS inverters showed sharp switching at close to the ideal value of one-half the supply voltage and, moreover, exhibited substantial DC gain of ≈45. The gain and the rail-to-rail output switching are consistent with the large noise margin and minimal static power consumption of CMOS. Vertically interconnected, three-stage CMOS ring oscillators were also fabricated by using layer-1 InAs NW n-FETs and layer-2 Ge/Si NW p-FETs. Significantly, measurements of these circuits demonstrated stable, self-sustained oscillations with a maximum frequency of 108 MHz, which represents the highest-frequency integrated circuit based on chemically synthesized nanoscale materials. These results highlight the flexibility of bottom-up assembly of distinct nanoscale materials and suggest substantial promise for 3D integrated circuits.

IC/microfluidic hybrid system for magnetic manipulation of biological cells

This paper introduces an integrated circuit (IC)/microfluidic hybrid system for magnetic manipulation of biological cells. The hybrid system consists of an IC and a microfluidic system fabricated on top. Biological cells attached to magnetic beads are suspended inside the microfluidic system that maintains biocompatibility. The IC contains a microcoil array circuit that produces spatially-patterned microscopic magnetic fields. Programmable, rapid reconfiguration of the field pattern made possible by the IC allows an efficient simultaneous manipulation of multiple individual bead-bound cells with precise position control. Two prototypes, SiGe/microfluidic and CMOS/microfluidic hybrid systems, validate the proposed approach.

Dual-DLL-based CMOS all-digital temperature sensor for microprocessor thermal monitoring

Todays microprocessors increasingly need on-chip temperature sensors for thermal and power management [1]. Since these sensors do not take part in the main computing activity but rather play the auxiliary, albeit important, role of temperature monitoring, their presence in terms of area, power, and design effort should be minimal, thus, all-digital sensors are desired. Temperature sensing based on temperature-dependent delays of inverters [2] could be suited for microprocessor applications, as it lends itself to digital implementation: by using a time-to-digital converter (TDC), an inverter delay can be compared to an absolute delay reference and converted to a digital temperature output [2] (Fig. 3.7.1). We report on an all-digital CMOS temperature sensor for microprocessor application, which also exploits temperature-dependent inverter delays within the TDC-based framework of Fig. 3.7.1. It, however, has two improvements over prior art of [2]. First, it removes the effect of process variation on inverter delays via calibration at one temperature point (instead of 2-point calibration of [2]), thus, reducing high volume production cost. Second, we use two fine-precision DLLs, one to synthesize a set of temperature-independent delay references in a closed loop, the other as a TDC to compare temperature-dependent inverter delays to the references. The use of DLLs simplifies sensor operation and yields a high measurement bandwidth (5kS/s) at 7b resolution, which could enable fast temperature tracking. This is in contrast to [2], where a counter-based cyclic TDC with an open-loop single delay-reference has a longer measurement time for a similar resolution.

Palm NMR and 1-Chip NMR

In our earlier work, we developed a 2-kg NMR system, which was 60 X lighter, 40× smaller, yet 60× more spin-mass sensitive than a 120-kg state-of-the-art commercial benchtop system. Here we report on two new nuclear magnetic resonance (NMR) systems that represent further orders-of-magnitude size reduction and lab-on-a-chip capability. The first system, which weighs 0.1 kg and can be held in the palm of a hand, is the smallest NMR system ever built, and is 1200× lighter, 1200× smaller, yet 150× more spin-mass sensitive than the commercial system. It is enabled by combining the physics of NMR with a CMOS RF transceiver. The second system, which even integrates a sample coil, directly interfaces the CMOS chip with a sample for lab-on-a-chip operation. The two systems detect biological objects such as avidin, human chorionic gonadotropin, and human bladder cancer cells.