Eduardo Bodnariuc Fontes

Brain stimulation modulates the autonomic nervous system, rating of perceived exertion and performance during maximal exercise

Background The temporal and insular cortex (TC, IC) have been associated with autonomic nervous system (ANS) control and the awareness of emotional feelings from the body. Evidence shows that the ANS and rating of perceived exertion (RPE) regulate exercise performance. Non-invasive brain stimulation can modulate the cortical area directly beneath the electrode related to ANS and RPE, but it could also affect subcortical areas by connection within the cortico-cortical neural networks. This study evaluated the effects of transcranial direct current stimulation (tDCS) over the TC on the ANS, RPE and performance during a maximal dynamic exercise. Methods Ten trained cyclists participated in this study (33±9 years; 171.5±5.8 cm; 72.8±9.5 kg; 10–11 training years). After 20-min of receiving either anodal tDCS applied over the left TC (T3) or sham stimulation, subjects completed a maximal incremental cycling exercise test. RPE, heart rate (HR) and R–R intervals (as a measure of ANS function) were recorded continuously throughout the tests. Peak power output (PPO) was recorded at the end of the tests. Results With anodal tDCS, PPO improved by ∼4% (anodal tDCS: 313.2±29.9 vs 301.0±19.8 watts: sham tDCS; p=0.043), parasympathetic vagal withdrawal was delayed (anodal tDCS: 147.5±53.3 vs 125.0±35.4 watts: sham tDCS; p=0.041) and HR was reduced at submaximal workloads. RPE also increased more slowly during exercise following anodal tDCS application, but maximal RPE and HR values were not affected by cortical stimulation. Conclusions The findings suggest that non-invasive brain stimulation over the TC modulates the ANS activity and the sensory perception of effort and exercise performance, indicating that the brain plays a crucial role in the exercise performance regulation.

Prefrontal cortex transcranial direct current stimulation associated with aerobic exercise change aspects of appetite sensation in overweight adults

This study investigated whether transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex (DLPFC) isolated or combined with aerobic exercise influenced the desire to eat, hunger, and satiety in overweight subjects. Nine volunteers underwent anodal or sham tDCS (2 mA; 20 min) over DLPFC and isocaloric exercise bouts (70%VO(2)R; ~200 kcal). The appetite sensations were evaluated by visual analogue scales at four moments: I - Baseline; II - After tDCS; III - Post-Exercise and IV - 30-min Post-Exercise. The tDCS on left DLPFC decreased the desire to eat at baseline (tDCS -26% vs. -14% Sham). The tDCS associated with exercise had greater suppressing effect in desire to eat compared to either tDCS or exercise alone (tDCS -39% vs. -27% Sham). Moreover, the tDCS associated with exercise decreased hunger (tDCS -48% vs. 36% Sham) and increased satiety (tDCS 28% vs. 7% Sham) immediately after exercise. The post-exercise 30-min recovery elicited an overall increase in appetite. However the increase in desire to eat and hunger after recovery was lower after tDCS (29% and 13%, respectively) compared to sham stimulation (77% and 113%, respectively). These findings in overweight subjects indicate that the combination of tDCS over DLPFC and aerobic exercise induced greater decrease in appetite sensations compared to anodal tDCS or exercise alone.

Transcranial direct current stimulation influences the cardiac autonomic nervous control

To investigate whether the manipulation of brain excitability by transcranial direct current stimulation (tDCS) modulates the heart rate variability (HRV), the effect of tDCS applied at rest on the left temporal lobe in athletes (AG) and non-athletes (NAG) was evaluated. The HRV parameters (natural logarithms of LF, HF, and LF/HF) was assessed in 20 healthy men before, and immediately after tDCS and sham stimulation. After anodal tDCS in AG the parasympathetic activity (HF(log)) increased (P<0.01) and the sympathetic activity (LF(log)) and sympatho-vagal balance (LF/HF(log)) decreased (P<0.01), whereas no significant effects were detected in NAG (P>0.05). No significant changes in HRV indexes were provoked by sham stimulation in both AG and NAG (P>0.05). In conclusion, tDCS applied on the left temporal lobe significantly increased the overall HRV in AG, enhancing the parasympathetic and decreasing the sympathetic modulation of heart rate. Consequently the sympatho-vagal balance decreased at rest in AG but not in NAG. Releasing a weak electric current to stimulate selected brain areas may induce favorable effects on the autonomic control to the heart in highly fit subjects.

The relationship between rating of perceived exertion and muscle activity during exhaustive constant-load cycling.

The aims of this study were to verify the relationship between rating of perceived exertion (RPE) and electromyography (EMG) increases during exhaustive constant-load cycling bouts and, to compare and to correlate the power outputs corresponding to perceived exertion threshold (PET) and neuromuscular fatigue threshold (NFT). 11 men completed 3-4 different exhaustive constant-load cycling bouts on a cycle ergometer, being RPE and EMG measured throughout the bouts. The linear regression of the RPEslope and EMGslope against the power output identified the PET and NFT intensity, respectively. There was a significant relationship between RPEslope and EMGslope (R(2)=0.69; P<0.01). However, the linearity of RPEslope (R(2)=0.93±0.07) was significantly higher (P<0.001) than EMGslope (R(2)=0.63±0.25). In addition, the RPEslope and EMGslope were related to time to exhaustion (r=-0.59 and r=-0.60; P<0.001). There was no significant difference (P=0.42) between PET (201.5±27.9W) and NFT (210.3±22.6W) and they were significantly correlated (r=0.78; P=0.005). Therefore, the RPE and EMG increases during exhaustive constant-load cycling bouts are related and, PET and NFT intensities are similar and closely associated.

Brain activity and perceived exertion during cycling exercise: an fMRI study

Background/aim Currently, the equipment and techniques available to assess brain function during dynamic exercise are limited, which has restricted our knowledge of how the brain regulates exercise. This study assessed the brain areas activated during cycling by making use of a novel cycle ergometer, constructed to measure functional MRI (fMRI) brain images during dynamic exercise. Furthermore, we compared brain activation at different levels of ratings of perceived exertion (RPE) generated during the exercise. Methods Seven healthy adults performed cycling exercise in a novel MRI compatible cycle ergometer while undergoing brain fMRI. Participants completed a cycling block protocol comprising six trials of 2 min cycling with 16-s intervals between trials. Participants reported their RPE every minute through an audio link. The MRI cycling ergometer transferred the torque generated on the ergometer through a cardan system to a cycling ergometer positioned outside the MRI room. For data analysis, the effects of cycling as opposed to rest periods were examined after motion correction. Results The multiparticipant analysis revealed in particular the activation of the cerebellar vermis and precentral and postcentral gyrus when periods of cycling versus rest were compared. Single participant analysis in four participants revealed that activation of the posterior cingulate gyrus and precuneus occurred in cycling blocks perceived as ‘hard’ compared with exercise blocks that were less demanding. Conclusions The present study offers a new approach to assess brain activation during dynamic cycling exercise, and suggests that specific brain areas could be involved in the sensations generating the rating of perceived exertion.

Electromyographic activity and rate of muscle fatigue of the quadriceps femoris during cycling exercise in the severe domain.

Camata, TV, Altimari, LR, Bortolotti, H, Dantas, JL, Fontes, EB, Smirmaul, BPC, Okano, AH, Chacon-Mikahil, MPT, and Moraes, AC. Electromyographic activity and rate of muscle fatigue of the quadriceps femoris during cycling exercise in the severe domain. J Strength Cond Res 25(9): 2537-2543, 2011—This study compared the activation pattern and the fatigue rate among the superficial muscles of the quadriceps femoris (QF) during severe cycling exercise. Peak oxygen consumption (&OV0312;o2peak) and maximal accumulated oxygen Deficit (MAOD) were established by 10 well-trained male cyclists (27.5 ± 4.1 years, 71.0 ± 10.3 kg, 173.4 ± 6.6 cm, mean &OV0312;o2peak 56.7 ± 4.4 ml·kg−1·min−1, mean MAOD 5.7 ± 1.1 L). Muscle activity (electromyographic [EMG] signals) was obtained during the supramaximal constant workload test (MAOD) and expressed by root mean square (RMS) and median frequency (MF slope). The RMS of the QF, vastus lateralis (VL) and vastus medialis (VM) muscles were significantly higher than at the beginning after 75% of exercise duration, whereas for the rectus femoris (RF), this was observed after 50% of exercise duration (p ≤ 0.05). The slope of the MF was significantly higher in the RF, followed by the VL and VM (−3.13 ± 0.52 vs. −2.61 ± 0.62 vs. −1.81 ±0.56, respectively; p < 0.05). We conclude that RF may play an important role in limiting performance during severe cycling exercise.

Does Prefrontal Cortex Transcranial Direct Current Stimulation Influence the Oxygen Uptake at Rest and Post-exercise?

The study evaluated the effect of transcranial direct current stimulation (tDCS) applied over prefrontal cortex on the oxygen uptake (V˙ O2) at rest and during post-exercise recovery. The V˙ O2 was assessed in eleven healthy subjects before, during tDCS (sham or anodal tDCS, 2 mA, 20 min), and 30-min following isocaloric aerobic exercise (~200 kcal). During tDCS, no changes were observed on V˙ O2 compared to baseline (P=0.95) and sham condition (P=0.85). The association between isocaloric exercise and anodal tDCS increased the V˙ O2 throughout 30-min recovery compared to sham condition (P

O nível de treinamento não influencia a percepção subjetiva de esforço durante um teste incremental

Different training levels, combined with experience in performing exhaustive exercise, may produce different sensations of fatigue. The objective of this study was to compare the rating of perceived exertion (RPE) between cyclists and non-cyclists during a maximal incremental test (ITMAX). Twenty-three subjects were recruited and divided into a cyclist group (CG) (n = 12; age: 26.5 ± 4.7 years, body weight: 68.2 ± 11kg, height: 176 ± 8.6 cm) and a non-cyclist group (NCG) (n = 11; 25.2 ± 4.0 years, body weight: 72.9 ± 9 kg, height: 175.1 ± 6.3 cm). All subjects performed an ITMAX until exhaustion on a cycling simulator, starting at 0 W and with increments of 20 W.min-1. RPE was measured at 30-second intervals during ITMAX and the maximal power output (PMAX) of each subject was also recorded. The total time of each test was normalized to the percentage of completed trial (10% to 100%, intervals of 10%), and the corresponding RPE was recorded. PMAX was 368 ± 12.7 W and 256 ± 11.2 W for CG and NCG, respectively (P < 0.01). No significant difference in median RPE was observed between groups at any time point. In conclusion, RPE responses did not differ between CG and NCG during ITMAX, suggesting that training level does not influence RPE.

Motor cortex tDCS does not modulate perceived exertion within multiple-sets of resistance exercises

BACKGROUND: Recent evidences have shown that the motor cortex (MC) may influence the rating of perceived exertion (RPE). Given the potential role of transcranial direct current stimulation (tDCS) in modulate cortical areas related to exercise performance, it is possible that tDCS applied on motor cortex (MC) could also influence the RPE during resistance exercises. OBJECTIVE: This study analyzed the effects of transcranial direct current stimulation on the rating of perceived exertion during multiple sets of resistance exercises. METHODS: Thirteen strength-trained men performed a resistance exercise session after either anodal tDCS or sham stimulation applied over the primary motor cortex. Resistance exercise sessions included 3 sets of 10 repetitions of 6 exercises performed with load of at 85% of 8–12 RM. The RPE was obtained using OMNI-Resistance exercise scale. RESULTS: The RPE assessed at the end of the sessions was similar in tDCS vs. sham condition (6.78 ± 1.48 vs. 6.87 ± 1.49, respectively; p = 0.56). The RPE for each exercise was similar across conditions, except for the second set of bench press (p = 0.04) and first set of seated-row (p = 0.03). CONCLUSION: In conclusion, the RPE during multiple sets of submaximal exercises was not modulated by tDCS applied upon

Estimulação cerebral na promoção da saúde e melhoria do desempenho físico

The technological advances of the last decades have provided the effective use of noninvasive techniques in neuromodulation with concomitant health benefits. Currently, the main neuromodulation techniques are transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). Through literature review, this study addresses the a) history of brain stimulation and the b) mechanisms of action studied by motor neurophysiology, pharmacology, neuroimaging, and experimental animals. Moreover, it is presented the c) perspectives for applications of brain stimulation for promoting health and improving physical performance, including cardiac autonomic control and post-exercise hypotension, control and modulation of appetite, fatigue and physical performance. Finally, we describe d) the security aspects related to the use of tDCS. Thus, tDCS seems to be an effective and safe technique to modulate brain function and suggests some application associated to food intake, cardiovascular health and physical performance.