Elena Dichiarante

Remarkable reversal of melting point alternation by co-crystallization

The pronounced melting point alternation of α,ω-alkanedicarboxylic acids (HOOC–(CH2)n−2–COOH, n = 4–10) is maintained in co-crystals of the same acids with 1,2-bis(4-pyridyl)ethane (BPA), which contains an even number of carbon atoms in the chain, and is reversed in co-crystals with 1,2-bis(4-pyridyl)propane (BPP), which contains an odd number of carbon atoms in the aliphatic chain.

Crystal forms of the hydrogen oxalate salt of o-desmethylvenlafaxine.

To prepare new crystalline forms of the antidepressant o‐desmethylvenlafaxine salt as potential new commercial forms and evaluate their physicochemical properties, in particular the dissolution rate.