Marco Curzi

Unprecedented mechanochemical preparation of 18Crown[6] and 15Crown[5] adducts of ammonium hydrogen sulfate by grinding or kneading

The complex 18Crown[6]·[NH4][HSO4]·2H2O has been prepared by co-grinding of solid 18Crown[6] ether and solid [NH4][HSO4], while the complex (15Crown[5])3·[NH4]2[H3O][HSO4]3·H2O has been obtained by kneading liquid 15Crown[5] together with solid [NH4][HSO4]. Structural characterization has been achieved on single crystals obtained by recrystallization of the solid products from water.

Mechanochemical and solution reactions between AgCH3COO and [H2NC6H10NH2] yield three isomers of the coordination network {Ag[H2NC6H10NH2]+}∞

Solid-state co-grinding of silver acetate and solid trans-1,4-diaminocyclohexane, [H2NC6H10NH2] yields two isomeric coordination networks depending on the crystallization conditions; a third isomeric form is obtained when the same reaction is carried out in solution.

Crystal synthesis of hybrid organometallic–inorganic hydrogen bonded salts of acid oxoanions

Partially deprotonated inorganic oxoanions derived from sulfuric and phosphoric acids have been used to assemble organometallic cations in inorganic-organometallic hybrid systems. The organometallic sandwich cations [(eta(5)-C(5)H(5))(2)Co]+, [(eta(5)-C(5)Me(5))(2)Co]+ and [(eta(5)-C(5)Me(5))(2)Fe]+ have been used because they do not interfere with hydrogen bonding formation forcing self-assembling of the inorganic acids anions HSO(4)(-) and H(2)PO(4)(-) into hydrogen bonded mono- and bi-dimensional networks.

Crystal forms of the hydrogen oxalate salt of o-desmethylvenlafaxine.

To prepare new crystalline forms of the antidepressant o‐desmethylvenlafaxine salt as potential new commercial forms and evaluate their physicochemical properties, in particular the dissolution rate.