Elizabeth Crew
Binghamton University
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Publication
Featured researches published by Elizabeth Crew.
Journal of Materials Chemistry | 2010
Lingyan Wang; Jin Luo; Jun Yin; Hao Zhang; Jinhui Wu; Xiajing Shi; Elizabeth Crew; Zhe Xu; Qiang Rendeng; Susan Lu; Mark D. Poliks; Bahgat Sammakia; Chuan-Jian Zhong
The thin film assembly of metal nanoparticles on flexible chemiresistor (CR) arrays represents an intriguing way to address the versatility of chemical sensor design. In this work, thin film assemblies of gold nanoparticles in size range of 2–8 nm diameters with high monodispersity (unlinked or linked by molecular mediators) were assembled on a CR array with a polyethylene terephthalate (PET) substrate to demonstrate the flexible chemiresistor characteristics of the nanostructured materials. The correlation between the relative change in electrical conductivity and the change in dielectric medium constant in response to flexible wrapping of the device demonstrated the viability of manipulating the electrical responses in terms of wrapping direction. The responses of the devices in response to volatile organic compounds (VOCs) were analyzed in terms of particle size, interparticle properties, and substrate–film interactions. For molecularly linked films with small particle size and large interparticle spacing, which is characterized by a high percentage of organics and linker molecules, the relatively low electrical conductivity renders the change in interparticle spacing able to play a dominant role in the sensor response to VOCs with small dielectric constants. The combination of a high percentage of linker molecules in the thin film assembly and a high dielectric constant for the VOCs was found to produce a negative response characteristic. In contrast, the response characteristic for the unlinked film via weak interparticle interactions was dominated by the change in interparticle spacing regardless of the percentage of organics in the nanostructure. The delineation between these factors and the sensing characteristics is useful in enabling a rationale design of the nanostructures on flexible chemiresistors.
Analytical Chemistry | 2011
Lingyan Wang; Jin Luo; Shiyao Shan; Elizabeth Crew; Jun Yin; Chuan-Jian Zhong; Brandi Wallek; Season Wong
The ability for silver nanoparticles to function as an antibacterial agent while being separable from the target fluids is important for bacterial inactivation in biological fluids. This report describes the analysis of the antimicrobial activities of silver-coated magnetic nanoparticles synthesized by wet chemical methods. The bacterial inactivation of several types of bacteria was analyzed, including Gram-positive bacteria ( Staphylococcus aureus and Bacillus cereus ) and Gram-negative bacteria ( Pseudomonas aeruginosa , Enterobacter cloacae , and Escherichia coli ). The results have demonstrated the viability of the silver-coated magnetic nanoparticles for achieving effective bacterial inactivation efficiency comparable to and better than that of silver nanoparticles conventionally used. The bacteria inactivation efficiency of our silver-coated MnZn ferrite (MZF@Ag) nanoparticles was also determined for blood platelets samples, demonstrating the potential of utilization in inactivating bacterial growth in platelets prior to transfusion to ensure blood product safety, which also has important implications for enabling the capability of effective separation, delivery, and targeting of the antibacterial agents.
Analytical Chemistry | 2012
Elizabeth Crew; Sharaara Rahman; Asma Razzak-Jaffar; Derrick Mott; Martha Kamundi; Gang Yu; Nuri Tchah; Jehwan Lee; Michael Bellavia; Chaun-Jian Zhong
While the importance of microRNAs (miRNAs) in cancer treatment or manipulation of genetic expression has been increasingly recognized for developing miRNA-based therapies, the controlled delivery of miRNAs into specific cells constitutes a challenging task. This report describes preliminary findings from an investigation of the conjugation of gold nanoparticles with miRNAs (miRNA-AuNPs) and their cell transfection. The immobilization of miRNAs on the AuNPs was detected, and the surface stability was substantiated by gel electrophoresis assessment of the highly charged characteristics of miRNA-AuNPs and their surface-exchange inactivity with a highly charged surfactant. The miRNA-AuNPs were tested in cell transfection using multiple myeloma cells, demonstrating efficient knockdown in the functional luciferase assay. The findings have important implications for understanding the mechanistic details of cell transfection involving miRNA-conjugated nanoparticles as biosensing or targeting probes.
ACS Applied Materials & Interfaces | 2014
Zakiya Skeete; Han-Wen Cheng; Elizabeth Crew; Liqin Lin; Wei Zhao; Pharrah Joseph; Shiyao Shan; Hannah Cronk; Jin Luo; Yong-Jun Li; Qunwei Zhang; Chuan-Jian Zhong
Nanostructured materials have found increasing applications in medical therapies and diagnostics (theranostics). The main challenge is the ability to impart the nanomaterials with structurally tailored functional properties which can effectively target biomolecules but also provide signatures for effective detection. The harnessing of functional nanoparticles and assemblies serves as a powerful strategy for the creation of the structurally tailored multifunctional properties. This article highlights some of the important design strategies in recent investigation of metals (especially gold and silver), and magnetically functionalized nanoparticles, and molecularly assembled or biomolecularly conjugated nanoparticles with tunable optical, spectroscopic, magnetic, and electrical properties for applications in several areas of potential theranostic interests. Examples include colorimetric detection of amino acids and small peptides, surface-enhanced Raman scattering detection of biomolecular recognition of proteins and DNAs, delivery in cell transfection and bacteria inactivation, and chemiresistive detection of breath biomarkers. A major emphasis is placed on understanding how the control of the nanostructures and the molecular and biomolecular interactions impact these biofunctional properties, which has important implications for bottom-up designs of theranostic materials.
Comprehensive Analytical Chemistry | 2014
Han-Wen Cheng; Zakiya Skeete; Elizabeth Crew; Shiyao Shan; Jin Luo; Chuan-Jian Zhong
Abstract Gold nanoparticles have become a focal point of interests in nanoscience and nanotechnology. This chapter describes the synthesis of gold nanoparticles in aqueous and organic phases with emphasis on understanding the growth mechanism in terms of sizes and properties and their relevance to analytical chemistry.
Langmuir | 2007
I-Im S. Lim; Wui Ip; Elizabeth Crew; Peter N. Njoki; Derrick Mott; Chuan-Jian Zhong; and Yi Pan; Shuiqin Zhou
Sensors and Actuators B-chemical | 2012
Jinghu Luo; Jin Luo; Lingyan Wang; Xiajing Shi; Jun Yin; Elizabeth Crew; Susan Lu; Leann M. Lesperance; Chuan-Jian Zhong
Journal of Materials Chemistry B | 2013
Liqin Lin; Elizabeth Crew; Hong Yan; Shiyao Shan; Zakiya Skeete; Derrick Mott; Tatiana Krentsel; Jun Yin; Natasha A. Chernova; Jin Luo; Mark H. Engelhard; Chongmin Wang; Qingbiao Li; Chuan-Jian Zhong
Analyst | 2013
Elizabeth Crew; Hong Yan; Liqin Lin; Jun Yin; Zakiya Skeete; Timur Kotlyar; Nuri Tchah; Jehwan Lee; Michael Bellavia; Isaac Goodshaw; Pharrah Joseph; Jin Luo; Susannah Gal; Chuan-Jian Zhong
Archive | 2012
Elizabeth Crew; Stephanie Lim; Hong Yan; Shiyao Shan; Jun Yin; Liqin Lin; Rameshwori Loukrakpam; Lefu Yang; Jin Luo; Chuan-Jian Zhong