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Essa Hu

Merck & Co.

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Publication

Featured researches published by Essa Hu.

Bioorganic & Medicinal Chemistry Letters | 2009

Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.

Yiwei Li; Jun Liang; Tony Siu; Essa Hu; Michael A. Rossi; Stanley F. Barnett; Deborah Defeo-Jones; Raymond E. Jones; Ronald G. Robinson; Karen R. Leander; Hans E. Huber; Sachin Mittal; Nicholas Cosford; Peppi Prasit

A series of [1,2,4]triazolo[3,4-f][1,6]naphthyridine allosteric dual inhibitors of Akt1 and 2 have been developed. These compounds have been shown to have potent dual Akt1 and 2 cell potency. The representative compound 13 provided potent inhibitory activity against Akt1 and 2 in vivo in a mouse model.

Journal of Organic Chemistry | 1998

Unprecedented Catalytic Three Component One-Pot Condensation Reaction: An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Essa Hu; Daniel R. Sidler; Ulf-H. Dolling

Bioorganic & Medicinal Chemistry Letters | 2004

Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

Essa Hu; Peter Chua; Lida R. Tehrani; Johnny Y. Nagasawa; Anthony B. Pinkerton; Blake Alan Rowe; Jean-Michel Vernier; John H. Hutchinson; Nicholas Cosford

Archive | 2004

Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors

Stephen D. Goble; Sander G. Mills; Lihu Yang; Alexander Pasternak; Celine Bonnefous; Theodore M. Kamenecka; Jean-Michel Vernier; John H. Hutchinson; Essa Hu; Steven P. Govek

Archive | 2004

4-Ring imidazole derivatives as modulators of metabotropic glutamate receptor-5

Nicholas Cosford; Dehua Huang; Nicholas D. Smith; Essa Hu

Archive | 1996

Process for making dihydropyrimidinones

Essa Hu; Daniel R. Sidler; Ulf H. Dolling; Michael A. Patane

Canadian Journal of Chemistry | 2002

Efficient synthesis of the optically active dihydropyrimidinone of a potent α1A- selective adrenoceptor antagonist

Daniel R. Sidler; Nancy Sue Barta; Wenjie Li; Essa Hu; Louis Matty; Nori Ikemoto; Jeffrey S Campbell; Michel Chartrain; Kozo Gbewonyo; Russell J. Boyd; Edward G. Corley; Richard G. Ball; Robert D. Larsen; Paul J. Reider

Journal of Organic Chemistry | 1996

Design and Asymmetric Synthesis of beta-Strand Peptidomimetics.

Ahcene Boumendjel; John C. Roberts; Essa Hu; Peter V. Pallai; Julius Rebek

Archive | 2005

Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors

Essa Hu; Jean-Michel Vernier; Peter Chua; John H. Hutchinson; Nicholas Cosford

Archive | 2006

Inhibiteurs de l'activite akt

Donna J. Armstrong; Essa Hu; Michael J. Kelly; Mark E. Layton; Yiwei Li; Jun Liang; Kevin J. Rodzinak; Michael A. Rossi; Philip E. Sanderson; Jiabing Wang

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Jean-Michel Vernier

General Atomics

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John H. Hutchinson

General Atomics

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Nicholas Cosford

General Atomics

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Daniel R. Sidler

Merck

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Dehua Huang

General Atomics

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Jun Liang

Merck

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Michael A. Rossi

Merck

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Nicholas D. P. Cosford

United States Military Academy

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Nicholas D. Smith

Merck

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Peter Chua

Merck

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